Patents by Inventor William D. Kingsbury

William D. Kingsbury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-neoplastic compounds, compositions and methods
    Patent number: 8680139
    Abstract: Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: March 25, 2014
    Assignee: Progenra
    Inventors: Ping Cao, Joseph Weinstock, William D. Kingsbury, Craig A. Leach, Suresh Kumar Kizhakkethil-George, Benjamin Nicholson
  • ANTI-NEOPLASTIC COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20120114765
    Abstract: Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.
    Type: Application
    Filed: March 31, 2010
    Publication date: May 10, 2012
    Inventors: Ping Cao, Joseph Weinstock, William D. Kingsbury, Craig A. Leach, Suresh Kumar Kizhakkethil-George, Benjamin Nicholson
  • Quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
    Patent number: 6100267
    Abstract: Pharmaceutical compositions and methods of inhibiting calpain using novel quinoline- or naphthatenecarboxamides are disclosed.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: August 8, 2000
    Assignees: SmithKline Beecham Corporation, Cephalon, Inc.
    Inventors: Robert A Daines, William D Kingsbury, Israil Pendrak, John P Mallamo
  • Pyridine compounds for treating leukotriene-related diseases
    Patent number: 5656636
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: August 12, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Pamela Anne Chambers, Robert A. Daines, Dalia R. Jakas, William D. Kingsbury, Israil Pendrak
  • Pyridine compounds for treating leukotriene-related diseases
    Patent number: 5633258
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: May 27, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Pamela A. Chambers, Robert A. Daines, Dalia R. Jakas, William D. Kingsbury, Israil Pendrak
  • Pyridine compounds for treating leukotriene-related diseases
    Patent number: 5631262
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: May 20, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Pamela A. Chambers, Robert A. Daines, Dalia R. Jakas, William D. Kingsbury, Israil Pendrak
  • Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
    Patent number: 5004758
    Abstract: Water soluble camptothecin analogs, pharmaceutical compositions comprising such analogs, and a method of inhibiting the growth of tumor cells sensitive to such analogs in an animal in need thereof.
    Type: Grant
    Filed: November 2, 1988
    Date of Patent: April 2, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Jeffrey C. Boehm, Sidney M. Hecht, Kenneth G. Holden, Randall K. Johnson, William D. Kingsbury
  • Oligopeptide prodrugs
    Patent number: 4479898
    Abstract: Prodrugs are described whose structures have a oligopeptide chain which is substituted by a nucleophilic chemotherapeutic residue at the .alpha.-position. The products have increased cell membrane permeability and beneficial physico-chemical properties.
    Type: Grant
    Filed: February 29, 1984
    Date of Patent: October 30, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: Charles Gilvarg, William D. Kingsbury
  • Oligopeptide prodrugs
    Patent number: 4454065
    Abstract: Prodrugs are described whose structures have a oligopeptide chain which is substituted by a nucleophilic chemotherapeutic residue at the .alpha.-position. The products have increased cell membrane permeability and beneficial physico-chemical properties.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: June 12, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: Charles Gilvarg, William D. Kingsbury
  • Antimicrobial disulfide prodrugs
    Patent number: 4427582
    Abstract: A series of prodrugs is described which have improved antimicrobial activity and physico-chemical properties. The structures of the biologically active ingredients are characterized by having a selected oligopeptide backbone attached, via the .alpha.-carbon of an L-alanyl unit thereof, by means of a disulfide link to the residue of an antimicrobial mercaptan.
    Type: Grant
    Filed: June 8, 1982
    Date of Patent: January 24, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: Charles Gilvarg, William D. Kingsbury
  • 5-Cycloalkyl thio- and oxy-2-carbalkoxyaminobenzimidazoles
    Patent number: 4258198
    Abstract: New anthelmintic compounds, compositions and methods of use are described utilizing 5-cycloalkylthio and oxy-2-carbalkoxyaminobenzimidazole. Methods of preparation involve the reaction of 4-cycloalkylthio- or oxy-o-phenylenediamine with methyl cyanocarbamate in aqueous miscible organic solvents.
    Type: Grant
    Filed: March 10, 1975
    Date of Patent: March 24, 1981
    Assignee: SmithKline Corporation
    Inventors: Robert J. Gyurik, William D. Kingsbury
  • Intermediate for dephthaloylation of azetidinone compounds
    Patent number: 4085100
    Abstract: A method for dephthaloylation of azetidinone compounds which contain a phthalimido group to produce useful aminoazetidinone intermediates comprises reaction with methyl hydrazine at low temperatures.
    Type: Grant
    Filed: November 1, 1976
    Date of Patent: April 18, 1978
    Assignee: SmithKline Corporation
    Inventor: William D. Kingsbury
  • Methods and compositions using 5-cycloalkylthio- and oxy-2-carbalkoxy-aminobenzimidazole
    Patent number: 4025638
    Abstract: New anthelmintic compositions and methods of use are described utilizing 5-cycloalkylthio and oxy-2-carbalkoxyaminobenzimidazoles as active ingredients.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: May 24, 1977
    Assignee: SmithKline Corporation
    Inventors: Robert J. Gyurik, William D. Kingsbury
  • 4-Sulfanilamidothiazole
    Patent number: 4011210
    Abstract: 4-Sulfanilamidothiazole having antibacterial activity is prepared from the previously unknown 4-aminothiazole.
    Type: Grant
    Filed: November 7, 1975
    Date of Patent: March 8, 1977
    Assignee: SmithKline Corporation
    Inventors: Gregory Gallagher, Jr., William D. Kingsbury
  • Methods for improving the feed intake of meat producing animals
    Patent number: 3978221
    Abstract: Compositions and methods for inducing polyphagia or eating in meat producing animals comprise administering orally or preferably by injection an effective but nontoxic subpharmacodynamic quantity of a benzhydryl ether active ingredient. Preferred active ingredients are tropine benzohydryl ether, 3-quinuclidinyl benzohydryl ether or their nontoxic acid addition salts.
    Type: Grant
    Filed: March 4, 1975
    Date of Patent: August 31, 1976
    Assignee: SmithKline Corporation
    Inventors: Clifton A. Baile, William D. Kingsbury, Roger C. Parish
  • Anthelmintic 5-heterocycliothio and oxy-2-carbalkoxyaminobenzimidazles
    Patent number: 3969526
    Abstract: New methyl benzimidazolecarbamate compounds having a heterocyclic thio or oxy moiety at position 5, useful as anthelmintics are described. Methyl-5-(pyridylthio)- and 5-(pyridylmethylthio)-benzimidazolecarbamates are preferred.
    Type: Grant
    Filed: December 9, 1974
    Date of Patent: July 13, 1976
    Assignee: SmithKline Corporation
    Inventors: Robert J. Gyurik, William D. Kingsbury
  • 4-Aminothiazole
    Patent number: 3939172
    Abstract: 4-Aminothiazole is prepared in stable useful form by alkaline hydrolysis of 4-trifluoroacetamidothiazole. Also prepared are 4-sulfathiazole and 2-(4-thaizolyl)-indazole.
    Type: Grant
    Filed: November 7, 1974
    Date of Patent: February 17, 1976
    Assignee: SmithKline Corporation
    Inventors: Gregory Gallagher, Jr., William D. Kingsbury