Patents by Inventor William Dackowski

William Dackowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polycystic kidney disease gene
    Patent number: 6867288
    Abstract: The present invention provides methods and compositions for treating cyst formation in PKD1-associated epithelial cells. Such methods encompass administering an isolated human PKD1 gene, or fragments of the gene, under conditions that result in expression of therapeutically effective amounts of all, or part of, the PKD1 protein. The invention also encompasses compositions for treating cyst formation associated with APKD.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 15, 2005
    Assignees: Genzyme Corporation, Johns Hopkins University
    Inventors: Katherine W. Klinger, Gregory M. Landes, Timothy C. Burn, Timothy D. Connors, William Dackowski, Gregory Germino, Feng Qian
  • Polycystic kidney disease gene and protein
    Patent number: 6071717
    Abstract: The present invention involves isolated nucleic acid encoding human PKD1, and sequences derived therefrom. The invention also encompasses vectors comprising these nucleic acids, host cells transformed with the vectors, and methods for producing PKD1 protein or fragments thereof. In another aspect, the invention involves isolated oligonucleotides that hybridize only to the authentic expressed PKD1 gene, and not to PKD1 homologues. In yet another aspect, the invention involves isolated mutant PKD1 genes, and their cDNA cognates. Further provided are isolated oligonucleotides that discriminate between normal and mutant versions of the PKD1 gene. Methods and compositions for treating APKD or disease conditions having the characteristics of APKD are also provided.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: June 6, 2000
    Assignees: Genzyme Corporation, Johns Hopkins University
    Inventors: Katherine Klinger, Timothy Burn, Timothy Connors, William Dackowski, Gregory Germino, Feng Qian, Gregory Landes
  • Human chromosome 16 genes, compositions, methods of making and using same
    Patent number: 6028173
    Abstract: This invention provides an isolated human netrin polypeptide. Netrins define a family of diffusable factors involved in axon outgrowth.
    Type: Grant
    Filed: June 17, 1996
    Date of Patent: February 22, 2000
    Assignee: Genzyme Corporation
    Inventors: Gregory Landes, Timothy Burn, Timothy Connors, William Dackowski, Terence Van Raay, Katherine Klinger
  • DNA probes for detecting the most common liveborn chromosomal aneuploidies
    Patent number: 5693783
    Abstract: Single stranded nucleic acid molecules, which can be used as probes to detect human chromosomes 13, 18, 21, X and Y are described. These probes are useful alone or in combination for diagnosing aneuploidies of the five chromosomes which comprise 95% of liveborn chromosomal aneuploidies.
    Type: Grant
    Filed: July 10, 1995
    Date of Patent: December 2, 1997
    Assignee: Genzyme Corporation
    Inventors: Katherine Klinger, William Dackowski, Greg Landes
  • Polycystic kidney disease gene
    Patent number: 5654170
    Abstract: The present invention involves isolated nucleic acid encoding human PKD1, and sequences derived therefrom. The invention also encompasses vectors comprising these nucleic acids, host cells transformed with the vectors, and methods for producing PKD1 protein or fragments thereof. In another aspect, the invention involves isolated oligonucleotides that hybridize only to the authentic expressed PKD1 gene, and not to PKD1 homologues. In yet another aspect, the invention involves isolated mutant PKD1 genes, and their cDNA cognates. Further provided are isolated oligonucleotides that discriminate between normal and mutant versions of the PKD1 gene. Methods and compositions for treating APKD or disease conditions having the characteristics of APKD are also provided.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: August 5, 1997
    Assignees: Johns Hopkins University, Genzyme Corporation
    Inventors: Katherine W. Klinger, Gregory M. Landes, Timothy C. Burn, Timothy D. Connors, William Dackowski, Gregory Germino, Feng Qian
  • Human uterine tissue plasminogen activator produced by recombinant DNA
    Patent number: 5344773
    Abstract: A replicable expression vector capable, in a transformed host mammallian cell, of expressing a DNA sequence encoding active human TPA which, when expressed in the host cell, yields active TPA which lacks one or more of the TPA-bound N-linked carbohydrate moieties of naturally occurring human TPA.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: September 6, 1994
    Assignee: Genzyme Corporation
    Inventors: Cha-Mer Wei, Nancy Hsiung, Vermuri B. Reddy, Jeffrey F. Lemontt, William Dackowski, Richard Douglas, Edward S. Cole, Richard D. Purcell, Jr., David Tai-Yui Lau
  • Vector containing DNA encoding mature human protein S
    Patent number: 5258288
    Abstract: Disclosed are a transformed mammalian cell that produces biologically active Protein S, and a vector for effecting the transformation of the cell. produces biologically active human Protein S, and the vector used to effect the transgenesis of the cell. The vector disclosed includes DNA encoding mature human Protein S, under the transcriptional control of a eukaryotic metallothionein gene, and also includes the transforming region of the bovine papilloma virus genome, and a fragment of SV40 DNA.
    Type: Grant
    Filed: July 25, 1986
    Date of Patent: November 2, 1993
    Assignee: Genzyme Corporation
    Inventors: Robert Wydro, Edward Cohen, William Dackowski, Johan Stenflo, Ake Lundwall, Bjorn Dahlback