Abstract: The present invention provides an adjustable organizer for cords or electrical leads. Advantageously, the position of the organizer can be adjusted without having to disassemble the organizer from the cords or electrical leads and with only one hand. The organizer can remain attached to the cords or electrical leads for the lifetime of the cords or electrical leads. The organizer can be cleaned or sterilized using the techniques that are suitable for cleaning or sterilizing the attached cords or electrical leads.

Abstract: A fail fixed actuator utilizing a rotary cam and servo are provided herein.

Abstract: Signal Transducer and Activator of Transcription (STAT) proteins have a fundamental role cell signaling, and are activated by a large number of cytokines and growth factors. One member of the STAT family, STAT3, has a critical role in oncogenesis. The present invention relates generally to disruption of the pathway of STAT3 signaling in the treatment of human cancer. STAT3 activation is shown to be present in diverse tumor cell lines and tumors, to promote oncogenesis, to inhibit apoptosis, and to reduce sensitivity to chemotherapeutic agents. Inhibition of STAT3 signaling induces apoptosis specifically in tumor cell lines, and increases sensitivity to chemotherapeutic agents. The invention relates more particularly to methods, compositions, means of administering such compositions, and means for identifying such compositions for the inhibition of STAT3 intracellular signaling in the treatment of human cancers.

Abstract: The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.

Abstract: A method for providing enhanced corrosion protection of metallic components and surfaces when exposing the metallic component to a silicate medium while applying an AC (Alternating Current) current.

Abstract: The present invention concerns fragments and variants of the HYD1 peptide; polynucleotides encoding the peptides; host cells genetically modified with the polynucleotides; vectors comprising the polynucleotides; compositions containing these peptides, polynucleotides, vectors, or host cells; and methods of using the peptides, polynucleotides, vectors, and host cells as inhibitors of aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as myeloma. The present invention further includes a method of increasing the efficacy of chemotherapy and radiation therapy, comprising administering an agent that binds ?1 integrin to a patient in need thereof. In one embodiment, the ?1 integrin binding agent is the HYD1 peptide, or a functional fragment or variant thereof.

Abstract: Peptides and methods of their use for inhibiting drug and radiation-therapy resistance in cancerous cells in which efficacy of chemotherapy and/or radiotherapy of a patient is enhanced by administration of an effective amount of a peptide that inhibits cell adhesion mediated drug resistance (CAM-DR). Preferably, the peptide comprises D-amino acids having the sequence: kmviywkag (RZ-3) or is a variant or modified version thereof. The peptide is preferably administered to the patient prior to chemotherapy and/or radiation therapy. Inhibition of cell adhesion mediated drug resistance (CAM-DR) by RZ-3 in multiple myeloma cells is disclosed.

Abstract: Computers, computer program products, and methods for identifying a plurality of subjects for a clinical trial are provided. A candidate set of molecular profiles in a stored plurality of molecular profiles are identified. Each such profile has measurements for a discriminating set of cellular constituents that match the measurements of corresponding cellular constituents in a responder set of biological samples, thereby identifying the plurality of subjects for the trial from those subjects from which the candidate set of molecular profiles were derived. Each respective molecular profile in the stored plurality of profiles has measurements of a plurality of cellular constituents from a respective biological sample in a plurality of samples obtained from a first plurality of subjects.

Abstract: A system for locking the axial position of an axial motion output device upon the loss of an electrical input signal includes a locking device operatively associated with the output device and adapted for movement between a neutral position in which the output device can move freely relative to the locking device and a locking position in which the locking device frictionally engages the output device with a sufficient amount of force to prevent further movement thereof upon the loss of an electrical input signal.

Abstract: The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.

Abstract: Signal Transducer and Activator of Transcription (STAT) proteins have a fundamental role cell signaling, and are activated by a large number of cytokines and growth factors. One member of the STAT family, STAT3, has a critical role in oncogenesis. The present invention relates generally to disruption of the pathway of STAT3 signaling in the treatment of human cancer. STAT3 activation is shown to be present in diverse tumor cell lines and tumors, to promote oncogenesis, to inhibit apoptosis, and to reduce sensitivity to chemotherapeutic agents. Inhibition of STAT3 signaling induces apoptosis specifically in tumor cell lines, and increases sensitivity to chemotherapeutic agents. The invention relates more particularly to methods, compositions, means of administering such compositions, and means for identifying such compositions for the inhibition of STAT3 intracellular signaling in the treatment of human cancers.

Abstract: A light bar contains one or more rows of light-emitting diodes (LED's) in a housing which extends across substantially the entire width of a windshield of a vehicle and is narrow in width to minimize interference with visibility through the windshield. The housing has an interior forming a channel with a throat; the throat acting as a hood which directs the illumination out of the windshield and minimizes stray light. The LED's are arranged in banks generally symmetrically arrayed about the center of the length of the housing. Two of the banks, preferably equidistant from the center, are tilted in opposite directions to each other so as to project light toward the right side and left side of the vehicle. The LED's may be illuminated continuously or in selected sequence, as established by the user with a switch on the housing. Attached to the housing in a separate compartment is another bank of LED's which may direct light inside the vehicle for use as a dome or map light.

Abstract: A seal segment for a turbine is provided having labyrinth teeth and a brush seal disposed along the labyrinth teeth. A plurality of the segments for a seal ring. The segments are separable from each other so that the seal can retract. Each segment has two ends, each of which abuts another segment, with those ends lying along a radius (when looking down the shaft of the turbine). The brush disposed in each segment has ends that do not lie along a radius, but fit together in a tongue and groove configuration when the seal segments come together to form a seal.

Abstract: The invention provides a computer network comprising a first computer and one or more second computers that are in electronic communication with each other. The first computer is associated with a first health care facility and has instructions for retrieving, over a network, one or more data structures for a patient enrolled in a health care program. The one or more data structures for the patient collectively comprise (i) a patient identifier, (ii) a molecular profile from a biological specimen obtained from the patient at the first health care facility; and (iii) a clinical characterization of the patient that was made at the first health care facility. The first computer has instructions for retrieving, over the network connection, one or a plurality of treatment regimens that are deemed suitable for the patient based upon the molecular profile and the clinical characterization of the patient.

Abstract: The disclosure relates to a process for forming a deposit on the surface of a metallic or conductive surface. The process employs an electrolytic process to deposit a silicate containing coating or film upon a metallic or conductive surface.

Abstract: Peptides and methods of their use for inhibiting drug and radiation-therapy resistance in cancerous cells in which efficacy of chemotherapy and/or radiotherapy of a patient is enhanced by administration of an effective amount of a peptide that inhibits cell adhesion mediated drug resistance (CAM-DR). Preferably, the peptide comprises D-amino acids having the sequence: kmviywkag (RZ-3) or is a variant or modified version thereof. The peptide is preferably administered to the patient prior to chemotherapy and/or radiation therapy. Inhibition of cell adhesion mediated drug resistance (CAM-DR) by RZ-3 in multiple myeloma cells is disclosed.

Abstract: A flow control system for controlling a variable displacement pump including a metering valve in fluid communication with the pump for metering an output of the pump. A regulating valve receives a portion of the output of the pump as a bypass flow at a first pressure, wherein an output of the regulating valve is at an interim pressure. The interim pressure is substantially equal to an average of the first pressure and a low reference pressure. An actuator sets a displacement of the pump by acting on a piston connected to a cam ring of the pump. The actuator receives the interim pressure and, thereby, the output of the variable displacement pump is determined.

Abstract: A multi-mode shutdown system in combination with a fuel metering unit of an engine to prevent normal fuel delivery during engine malfunction such as the engine overspeeding. The multi-mode shutdown system includes a shutdown solenoid capable of closing a pressurizing valve to prevent fuel flow to the engine for creating a shutdown mode of operation with no fuel flow to the engine. The multi-mode shutdown system also includes a minimum flow solenoid in fluid communication a source of fuel at a minimum flow rate for creating a minimum flow mode of operation with fuel provided to the engine at the minimal flow rate. In the minimum flow mode, the shutdown solenoid and minimum flow solenoid establish a flow path for the fuel to the engine manifold at the minimal flow rate. During normal operation, the fuel metering unit regulates the fuel flow to the engine.

Abstract: The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.