Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: A set of user interface tools is described facilitating asynchronous adjudication of one or more regions-of-interest in a medical image by a group of two or more graders, each of which has access to the set of tools in a workstation environment. The set of tools include (1) a feature for enabling the graders to assess the medical image and manually delineate one or more specific regions-of-interest (ROI) in the medical image, (2) a feature for assessing the ROI(s) delineated by other graders, including display of the ROI delineated by other graders; (3) dialog features for explaining and discussing the assessments, including a text feature for discussing the assessments. The dialog features and the ROIs delineated by all the graders are visible to all the graders on the workstation display as they collectively adjudicate the medical image in a round-robin manner. The set of tools further include (4) a feature for manually verifying grader agreement with the other graders' assessments.

Abstract: In various applications, the system provides a method for processing audio signals, including: receiving, by a processor, a digital audio signal from a recorded audio file; analyzing, by the processor, the digital audio signal to identify pitch distortion caused by changes in momentary sound level; determining, by the processor, an amount of compensation of the audio signal to correct the identified pitch distortion; dynamically adjusting, by the processor, the digital audio signal by the compensation amount to correct the identified pitch distortion; and outputting, by the processor, the digital audio signal to an audio transducer device of a listener to improve a listening experience for the listener of the recorded audio file.

Abstract: The disclosed embodiments relate to a system that supports dynamic bursts to facilitate frequency-agile communication between a memory controller and a memory device. During operation, the system monitors a reference clock signal received at an interface between the memory device and the memory controller. Upon detecting a frequency change in the reference clock signal from a fullrate to a subrate, the interface operates in a burst mode, wherein data is communicated through bursts separated by intervening low-power intervals during which portions of the interface are powered down.

Abstract: In various applications, the system provides a method for processing audio signals, including: receiving a request for audio content; receiving an identifier encoded in a personal audio device comprising a transducer for playing audio; retrieving at least one parameter associated with the identifier; and processing the audio content using at least the request, the identifier and the at least one parameter, wherein the processing is customized for the personal audio device based on the at least one parameter associated with the identifier.

Abstract: In some embodiments, a method receives a distribution area identifier for media content. A distribution area is defined by one or more geographic primitives and associated with a distribution area identifier. A geographic primitive is defined by one or more location identifiers. The method determines whether the one or more geographic primitives of the media content is applicable to a geographic primitive that is determined from a location identifier associated with a request.

Abstract: The disclosed embodiments relate to a system that supports dynamic bursts to facilitate frequency-agile communication between a memory controller and a memory device. During operation, the system monitors a reference clock signal received at an interface between the memory device and the memory controller. Upon detecting a frequency change in the reference clock signal from a fullrate to a subrate, the interface operates in a burst mode, wherein data is communicated through bursts separated by intervening low-power intervals during which portions of the interface are powered down.

Abstract: In some embodiments, a method receives a plurality of distribution areas. A distribution area is defined by one or more geographic primitives and associated with a distribution area identifier. Also, a geographic primitive is defined by one or more location identifiers. The method stores distribution area identifiers for the plurality of distribution areas in a first data structure. Information for media content is received and the method generates a content bundle for the media content based on the information for the media content. The content bundle is associated with a distribution area identifier and metadata that describes characteristics of the media content. The content bundle is stored in a second data structure.

Abstract: In various applications, the system provides a method for processing audio signals, including: receiving a request for audio content; receiving an identifier encoded in a personal audio device comprising a transducer for playing audio; retrieving at least one parameter associated with the identifier; and processing the audio content using at least the request, the identifier and the at least one parameter, wherein the processing is customized for the personal audio device based on the at least one parameter associated with the identifier.

Abstract: Disclosed herein, among other things, are systems and methods to facilitate generation of personalized digital content. A display is provided on a graphical user interface (GUI) of at least one user device, the display including an interactive portion for the user to select percentages of a plurality of digital content types from at least one server. A user selection is received corresponding to two or more percentages according to two or more digital content types. Digital content of the two or more digital content types is retrieved from a database associated with the at least one server. Personalized digital content is generated based on the two or more digital content types according to the two or more percentages by stitching the retrieved digital content according to the user selection. The personalized digital content is transmitted to at least one user device.

Abstract: The disclosed embodiments relate to a system that supports dynamic bursts to facilitate frequency-agile communication between a memory controller and a memory device. During operation, the system monitors a reference clock signal received at an interface between the memory device and the memory controller. Upon detecting a frequency change in the reference clock signal from a fullrate to a subrate, the interface operates in a burst mode, wherein data is communicated through bursts separated by intervening low-power intervals during which portions of the interface are powered down.

Abstract: In some embodiments, a method receives a plurality of distribution areas. A distribution area is defined by one or more geographic primitives and associated with a distribution area identifier. Also, a geographic primitive is defined by one or more location identifiers. The method stores distribution area identifiers for the plurality of distribution areas in a first data structure. Information for media content is received and the method generates a content bundle for the media content based on the information for the media content. The content bundle is associated with a distribution area identifier and metadata that describes characteristics of the media content. The content bundle is stored in a second data structure.

Abstract: A low-power, high-performance source-synchronous chip interface which provides rapid turn-on and facilitates high signaling rates between a transmitter and a receiver located on different chips is described in various embodiments. Some embodiments of the chip interface include, among others: a segmented “fast turn-on” bias circuit to reduce power supply ringing during the rapid power-on process; current mode logic clock buffers in a clock path of the chip interface to further reduce the effect of power supply ringing; a multiplying injection-locked oscillator (MILO) clock generator to generate higher frequency clock signals from a reference clock; a digitally controlled delay line which can be inserted in the clock path to mitigate deterministic jitter caused by the MILO clock generator; and circuits for periodically re-evaluating whether it is safe to retime transmit data signals in the reference clock domain directly with the faster clock signals.

Abstract: The disclosed embodiments relate to a system that supports dynamic bursts to facilitate frequency-agile communication between a memory controller and a memory device. During operation, the system monitors a reference clock signal received at an interface between the memory device and the memory controller. Upon detecting a frequency change in the reference clock signal from a fullrate to a subrate, the interface operates in a burst mode, wherein data is communicated through bursts separated by intervening low-power intervals during which portions of the interface are powered down.

Abstract: In one embodiment, a method defines a plurality of geographic primitives. A geographic primitive is defined by one or more location identifiers. A plurality of distribution areas are generated where a distribution area is defined by one or more of the geographic primitives. The method assigns one of the distribution areas to each of a plurality of pieces of media content. Then, the method stores the assigned one of the plurality of distribution areas for each of the plurality of pieces of media content in a database. One or more of the plurality of pieces of media content are published with the assigned one of the distribution areas. The assigned one of the distribution areas is usable to determine which media content in the one or more of the plurality of pieces of media content is available to users.

Abstract: In one embodiment, a method defines a plurality of geographic primitives that are defined by one or more location identifiers. A plurality of distribution areas are generated where a distribution area is defined by one or more of the geographic primitives. The method assigns one of the plurality of distribution areas to each of a plurality of pieces of media content. A request is received from a client device that is associated with a location identifier. The method performs a reverse lookup query to a database using a geo-mapping service to retrieve a set of distribution areas that include a geographical primitive associated with the location identifier and selects one or more pieces of media content from the plurality of pieces of media content. Information for at least a portion of the one or more pieces of media content is then provided to the client device.

Abstract: In various applications, the system provides a method for processing audio signals, including: receiving a request for audio content; receiving an identifier encoded in a personal audio device comprising a transducer for playing audio; retrieving at least one parameter associated with the identifier; and processing the audio content using at least the request, the identifier and the at least one parameter, wherein the processing is customized for the personal audio device based on the at least one parameter associated with the identifier.

Abstract: A low-power, high-performance source-synchronous chip interface which provides rapid turn-on and facilitates high signaling rates between a transmitter and a receiver located on different chips is described in various embodiments. Some embodiments of the chip interface include, among others: a segmented “fast turn-on” bias circuit to reduce power supply ringing during the rapid power-on process; current mode logic clock buffers in a clock path of the chip interface to further reduce the effect of power supply ringing; a multiplying injection-locked oscillator (MILO) clock generator to generate higher frequency clock signals from a reference clock; a digitally controlled delay line which can be inserted in the clock path to mitigate deterministic jitter caused by the MILO clock generator; and circuits for periodically re-evaluating whether it is safe to retime transmit data signals in the reference clock domain directly with the faster clock signals.

Abstract: A low-power, high-performance source-synchronous chip interface which provides rapid turn-on and facilitates high signaling rates between a transmitter and a receiver located on different chips is described in various embodiments. Some embodiments of the chip interface include, among others: a segmented “fast turn-on” bias circuit to reduce power supply ringing during the rapid power-on process; current mode logic clock buffers in a clock path of the chip interface to further reduce the effect of power supply ringing; a multiplying injection-locked oscillator (MILO) clock generator to generate higher frequency clock signals from a reference clock; a digitally controlled delay line which can be inserted in the clock path to mitigate deterministic jitter caused by the MILO clock generator; and circuits for periodically re-evaluating whether it is safe to retime transmit data signals in the reference clock domain directly with the faster clock signals.

Abstract: In various applications, the system provides a method for processing audio signals, including: receiving a request for audio content; receiving an identifier encoded in a personal audio device comprising a transducer for playing audio; retrieving at least one parameter associated with the identifier; and processing the audio content using at least the request, the identifier and the at least one parameter, wherein the processing is customized for the personal audio device based on the at least one parameter associated with the identifier.