Abstract: A system for full duplex real time two-way voice and data communication between a pair of computer terminal locations is disclosed. Analog voice signals are converted to digital form at one terminal location and those digital signals are interleaved with other digital information for transmission to the other terminal location. A value for the number of bytes, in a data packet is first established, and then values for the number of bytes and the location dedicated to the transmission of voice information, control information, and data transmission within such fixed size data packets is established. Thereafter, a sequence of data packets with synchronization bytes in the voice byte locations is transmitted from each computer terminal location and received by the other of the terminal location. Upon receipt thereof, an acknowledgement of the receipt is transmitted back to the originating location to indicate the establishment of synchronization between the two locations.