Abstract: A system and method for on-site remediation and sanitization of household items preferably uses a HEPA vacuum to remove surface microbials from the item being remediated. The item is then placed into a sealable plastic vacuum bag having a connection port that allows a vacuum to remove air from the bag, collapsing the bag over the item (which has first been braced to the extent necessary to prevent damage to the item). Once the air has been extracted from the vacuum bag air is introduced into the bag, preferably by using a blower, whereby a fogger can be used to introduce a remediating fog into the bag with the remediating fog surrounding the item. Next, the vacuum is used to again collapse the bag around the item, thereby infusing the remediating fog into the item. In a preferred embodiment of the invention the steps of inflating, fogging, and collapsing may be repeated one or more times to thoroughly infuse the remediating solution into the item, after which the item is removed from the vacuum bag.