Patents by Inventor William Demaio

William Demaio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tanaproget derivatives, metabolites, and uses thereof
    Patent number: 8389698
    Abstract: A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.
    Type: Grant
    Filed: June 26, 2009
    Date of Patent: March 5, 2013
    Assignee: Wyeth LLC
    Inventors: Li Shen, Kelly Keating, Oliver McConnell, William DeMaio, Appavu Chandrasekaran
  • TANAPROGET DERIVATIVES, METABOLITES, AND USES THEREOF
    Publication number: 20090306000
    Abstract: A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.
    Type: Application
    Filed: June 26, 2009
    Publication date: December 10, 2009
    Applicant: Wyeth
    Inventors: Li Shen, Kelly Keating, Oliver McConnell, William DeMaio, Appavu Chandrasekaran
  • Tanaproget derivatives, metabolites, and uses thereof
    Patent number: 7569679
    Abstract: A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: August 4, 2009
    Assignee: Wyeth
    Inventors: Li Shen, Kelly Keating, Oliver McConnell, William DeMaio, Appavu Chandrasekaran
  • Glucuronide metabolites and epimers thereof of tigecycline
    Patent number: 7534766
    Abstract: A glucuronide metabolite of tigecycline, and its corresponding epimer, have been identified in humans treated with tigecycline. Mass spectral data have been used to identify these structures.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: May 19, 2009
    Assignee: Wyeth
    Inventors: Ronald A. Jordan, William DeMaio, Matthew Hoffmann
  • Isolated hydroxy and n-oxide metabolites and derivatives of O-desmethylvenlafaxine and methods of treatment
    Publication number: 20080261895
    Abstract: The present invention provides novel isolated compounds characterized as metabolites or derivatives of desmethylvenlafaxine including hydroxy-DV metabolites, hydroxy-DV-glucuronide metabolites, N-oxide-DV metabolites, and benzyl-hydroxy-DV metabolites. The invention includes pharmaceutical compositions comprising any of the metabolites or derivatives of the invention in combination with a pharmaceutically acceptable carrier or excipient. The invention also includes a method of treating at least one central nervous system disorder in a mammal comprising providing to a mammal in need thereof an effective amount of the compounds of the invention.
    Type: Application
    Filed: October 24, 2007
    Publication date: October 23, 2008
    Inventors: Matthew J. Hoffmann, William DeMaio, Jim Wang, John W. Ullrich
  • Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof
    Publication number: 20080262228
    Abstract: The present invention relates to novel metabolites of 5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl}quinoline, which can be useful in treating CNS disorders. The present invention further relates to processes for their preparation, to pharmaceutical compositions comprising them, and to methods of using them.
    Type: Application
    Filed: November 27, 2007
    Publication date: October 23, 2008
    Applicant: Wyeth
    Inventors: Jianyao Wang, Alana Upthagrove, Lin Deng, Wayne Everett Childers, Zhongqi Shen, William Demaio, Robin D. Moore, Zeen Tong, Li Shen, Pixu Li, Michael K. May
  • Dihydrobenzofuran derivatives and uses thereof
    Patent number: 7402687
    Abstract: Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, R3, R4, Rx, Ry, and n are as defined herein. Such compounds, and compositions thereof, are useful for treating a variety of central nervous system disorders such as schizophrenia.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: July 22, 2008
    Assignee: Wyeth
    Inventors: Gary Paul Stack, Jianyao Wang, William Demaio, Ronald Jordan, John Chuck Lem Erve, Rasmy Elsayed Talaat, Matthew John Hoffmann
  • Dihydrobenzofuran derivatives and uses thereof
    Publication number: 20060241176
    Abstract: Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, R3, R4, Rx, Ry, and n are as defined herein. Such compounds, and compositions thereof, are useful for treating a variety of central nervous system disorders such as schizophrenia.
    Type: Application
    Filed: April 21, 2006
    Publication date: October 26, 2006
    Applicant: Wyeth
    Inventors: Gary Stack, Christine Huselton, Jianyao Wang, William Demaio, Ronald Jordan, John Erve, Rasmy Talaat, Matthew Hoffmann
  • Glucuronide metabolites and epimers thereof of tigecycline
    Publication number: 20060128950
    Abstract: A glucuronide metabolite of tigecycline, and its corresponding epimer, have been identified in humans treated with tigecycline. Mass spectral data have been used to identify these structures.
    Type: Application
    Filed: November 2, 2005
    Publication date: June 15, 2006
    Inventors: Ronald Jordan, William DeMaio, Matthew Hoffmann
  • Metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof
    Publication number: 20060111305
    Abstract: The invention relates to metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof. Specifically, the invention relates to compounds of formula I wherein the various substituents are defined herein. The invention also provides pharmaceutical compositions including compounds of formula I, methods of making such compounds, and methods of using such compounds.
    Type: Application
    Filed: November 4, 2005
    Publication date: May 25, 2006
    Applicant: Wyeth
    Inventors: Zeen Tong, Jim Wang, William DeMaio, Alvin Bach, Ronald Jordan, Youchu Wang, P. Sivaramakrishnan Ramamoorthy, Gary Stack
  • Tanaproget derivatives, metabolites,and uses thereof
    Publication number: 20060035843
    Abstract: A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 16, 2006
    Applicant: Wyeth
    Inventors: Li Shen, Kelly Keating, Oliver McConnell, William DeMaio, Appavu Chandrasekaran