Abstract: The invention relates to novel compounds of formula (I) wherein R is a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group and R.sup.2 is selected from the group consisting of: (a) a straight-chained or branched C.sub.5 -C.sub.12 alkyl radical; (b) a group --O--R.sup.4, wherein R.sup.4 is a straight-chained or branched C.sub.2 -C.sub.9 alkyl radical which may be substituted at the terminal carbon atom by a phenyl group; (c) a group --(CH.sub.2).sub.n --O--alkyl, wherein n is an integer of from 1 to 7 and the alkyl group contains from 1 to 5 carbon atoms, having the (3S,4S) configuration, essentially free of the (3R,4R) enantiomer. The invention also relates to process for the preparation of compounds of formula (I) as defined above. The invention further relates to pharmaceutical compositions which possess analgesic, anti-inflammatory, anti-emetic, anti-glaucoma, leukocytes antiadhesion or PAF activity, containing as active ingredient compounds of formula (I) as defined above.

Abstract: Pure polyunsaturated fatty acid amides and their derivatives. These synthcally produced compounds are able to mimic naturally occuring anandamides in the brain and bind the cannabinoid receptor. The compounds exhibit physiological activity and are useful as active ingredients in pharmaceutical compositions for the treatment of inflammation, migraines, spasticity activity, glaucoma, multiple sclerosis. The active compounds can be provided in isotope-tagged form.

Abstract: The invention relates to compounds of the formula ##STR1## having the (3S,4S) configuration and being essentially free of the (3R,4R) enantiomer, in which A--B indicates an optional 1(2) or 6(1) double bond, X is carboxy, carbalkoxy, or carboxamido, linked to the ring directly or through an alkylene linkage, G is halogen, alkyl, or oxy, and Y is alkyl, oxy, or oxyalkylene. The invention further relates to the synthesis of such compounds, and to pharmaceutical compositions and therapeutic methods in which such compounds may be employed.