Abstract: The present invention relates to novel substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions.

Abstract: The present invention relates to novel blood-brain barrier (BBB) penetrable substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions.

Abstract: A system and method are provided for modifying one portion of a user interface according to an interaction with a message, by displaying content associated with an item. The method includes receiving a message from a correspondent in a conversational message exchange; processing the message to detect at least one portion of the message indicative of an item; and displaying the message in a first portion of a user interface and identifying the at least one portion of the message. The method also includes detecting an interaction with the message; and modifying a second portion of the user interface comprising content associated with the correspondent, according to the interaction with the message, the modifying comprising displaying content associated with the item. Related computer-readable media are also disclosed.

Abstract: An image processing method comprising: receiving MRI data representing a scan of an organ of a patient, the MRI data including multiecho data for a plurality of pixels; for each of a plurality of pixels of the MRI data: fitting the multiecho data to a simulated decay curve; calculating a tissue index based on at least one parameter of the simulated decay curve; and comparing the tissue index to a threshold to determine a tissue type; wherein each pixel of the multiecho data consists of 16 or fewer echoes.

Abstract: A computer-implemented method for generating secondary notifications, the method including receiving a message; generating a primary notification of the message; updating a priority associated with the message; determining that the updated priority exceeds a threshold; and responsive to determining that the updated priority exceeds a threshold, generating a secondary notification, the secondary notification being distinct from the primary notification.

Abstract: A manipulator for separating sub-conductors in an energized single phase bundle includes a rigid support member and first and second actuators mounted on the support member, wherein each actuator is independently actuable of the other. Insulators are mounted on each actuator. A selectively releasable coupler is mounted on each insulator for selectively releasable coupling of each insulator to a corresponding sub-conductor. The actuators extend corresponding insulators independently of one another from the support member to thereby separate from each other by an optimized separation distance the distal ends of each insulator. When the corresponding sub-conductors of the single phase bundle are releasably coupled to the corresponding distal ends of the insulators the surge impedance loading of the single phase bundle may be improved by separation of the corresponding distal ends of the insulators and the sub-conductors by the optimized separation distance.

Abstract: A turbocharger compressor housing is configured to allow a releasable fixed adjustment of a geometry of a compressor housing to increase at least one of responsiveness, efficiency or the ultimate power obtainable by a turbocharged system. Adjustability can be provided by an air intake pipe that is threadably connected with a central portion of the compressor housing to allow an air gap between the housing and the intake pipe to be adjusted to create an effect similar to adjusting the inducer area of a compressor wheel disposed in the housing, whereby power can be exchanged for efficiency and responsiveness. Set screws may be used to releasably fix the position of the intake pipe relative to the compressor housing.

Abstract: A manipulator for separating sub-conductors in an energized single phase bundle includes a rigid support member and first and second actuators mounted on the support member, wherein each actuator is independently actuable of the other. Insulators are mounted on each actuator. A selectively releasable coupler is mounted on each insulator for selectively releasable coupling of each insulator to a corresponding sub-conductor. The actuators extend corresponding insulators independently of one another from the support member to thereby separate from each other by an optimized separation distance the distal ends of each insulator. When the corresponding sub-conductors of the single phase bundle are releasably coupled to the corresponding distal ends of the insulators the surge impedance loading of the single phase bundle may be improved by separation of the corresponding distal ends of the insulators and the sub-conductors by the optimized separation distance.

Abstract: Compounds and methods for inhibiting growth of a protozoan parasite. Methods of treating a protozoan parasite infection in a subject by administering a therapeutically effective amount of a compound as disclosed herein. The compounds and methods can be used to inhibit growth of protozoan parasites such as Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., and Plasmodium spp.

Abstract: A manipulator for separating sub-conductors in an energized single phase bundle includes a rigid support member and first and second actuators mounted on the support member, wherein each actuator is independently actuable of the other. Insulators are mounted on each actuator. A selectively releasable coupler is mounted on each insulator for selectively releasable coupling of each insulator to a corresponding sub-conductor. The actuators extend corresponding insulators independently of one another from the support member to thereby separate from each other by an optimized separation distance the distal ends of each insulator. When the corresponding sub-conductors of the single phase bundle are releasably coupled to the corresponding distal ends of the insulators the surge impedance loading of the single phase bundle may be improved by separation of the corresponding distal ends of the insulators and the sub-conductors by the optimized separation distance.

Abstract: A boom mountable robotic arm for temporarily supporting an elongate conductor includes a rigid member such as a beam or beam assembly adapted for mounting onto the upper end of a boom for example using a boom adaptor, at least one electrically insulated support post mounted to the rigid member, where each post temporarily supports an elongate electrical conductor, and at least two rotation devices for selectively controllable rotation of the rigid member and the electrically insulated support posts about at least two corresponding axes of rotation.

Abstract: A manipulator for separating sub-conductors in an energized single phase bundle includes a rigid support member and first and second actuators mounted on the support member, wherein each actuator is independently actuable of the other. Insulators are mounted on each actuator. A selectively releasable coupler is mounted on each insulator for selectively releasable coupling of each insulator to a corresponding sub-conductor. The actuators extend corresponding insulators independently of one another from the support member to thereby separate from each other by an optimized separation distance the distal ends of each insulator. When the corresponding sub-conductors of the single phase bundle are releasably coupled to the corresponding distal ends of the insulators the surge impedance loading of the single phase bundle may be improved by separation of the corresponding distal ends of the insulators and the sub-conductors by the optimized separation distance.

Abstract: A boom mountable robotic arm for includes a beam pivotally mounted on a boom mounting adaptor, at least two electrically insulated support posts mounted to and spaced apart along the beam, and at least a first rotation coupling and a plurality of second rotation couplings. The first rotation coupling provides pivotal mounting of the beam on the boom mounting adaptor so as to provide selectively controllable rotation of the beam in a substantially vertical plane. The second rotation couplings provide selectively controllable rotation of the electrically insulated support posts about corresponding second axes of rotation between a retracted position substantially laid flush along the beam and a pick-up position ready to receive a conductor being supported. An actuated scissor linkage is mounted to the beam and the boom mounting adaptor for selectively adjusting an angular position of the beam relative to the boom mounting adaptor.

Abstract: A boom mountable robotic arm for includes a beam pivotally mounted on a boom mounting adaptor, at least two electrically insulated support posts mounted to and spaced apart along the beam, and at least a first rotation coupling and a plurality of second rotation couplings. The first rotation coupling provides pivotal mounting of the beam on the boom mounting adaptor so as to provide selectively controllable rotation of the beam in a substantially vertical plane. The second rotation couplings provide selectively controllable rotation of the electrically insulated support posts about corresponding second axes of rotation between a retracted position substantially laid flush along the beam and a pick-up position ready to receive a conductor being supported. An actuated scissor linkage is mounted to the beam and the boom mounting adaptor for selectively adjusting an angular position of the beam relative to the boom mounting adaptor.

Abstract: A boom mountable robotic arm for temporarily supporting an elongate conductor includes a rigid member such as a beam or beam assembly adapted for mounting onto the upper end of a boom for example using a boom adaptor, at least one electrically insulated support post mounted to the rigid member, where each post temporarily supports an elongate electrical conductor, and at least two rotation devices for selectively controllable rotation of the rigid member and the electrically insulated support posts about at least two corresponding axes of rotation.

Abstract: A boom mountable robotic arm for temporarily supporting an elongate conductor includes a rigid member such as a beam or beam assembly adapted for mounting onto the upper end of a boom for example using a boom adaptor, at least one electrically insulated support post mounted to the rigid member, where each post temporarily supports an elongate electrical conductor, and at least two rotation devices for selectively controllable rotation of the rigid member and the electrically insulated support posts about at least two corresponding axes of rotation.

Abstract: A manipulator for separating sub-conductors in an energized single phase bundle includes a rigid support member and first and second actuators mounted on the support member, wherein each actuator is independently actuable of the other. Insulators are mounted on each actuator. A selectively releasable coupler is mounted on each insulator for selectively releasable coupling of each insulator to a corresponding sub-conductor. The actuators extend corresponding insulators independently of one another from the support member to thereby separate from each other by an optimized separation distance the distal ends of each insulator. When the corresponding sub-conductors of the single phase bundle are releasably coupled to the corresponding distal ends of the insulators the surge impedance loading of the single phase bundle may be improved by separation of the corresponding distal ends of the insulators and the sub-conductors by the optimized separation distance.

Abstract: A method and apparatus for handling and/or stringing energized conductor for a high voltage power line conductor for a high voltage power line is provided. The method includes bringing components and workers to the same electrical potential and transferring power from one contractor to another. Associated apparatus is also described.

Abstract: A boom mountable robotic arm for temporarily supporting an elongate conductor includes a rigid member such as a beam or beam assembly adapted for mounting onto the upper end of a boom for example using a boom adaptor, at least one electrically insulated support post mounted to the rigid member, where each post temporarily supports an elongate electrical conductor, and at least two rotation devices for selectively controllable rotation of the rigid member and the electrically insulated support posts about at least two corresponding axes of rotation.

Abstract: A boom mountable robotic arm for temporarily supporting an elongate conductor includes a rigid member such as a beam or beam assembly adapted for mounting onto the upper end of a boom for example using a boom adaptor, at least one electrically insulated support post mounted to the rigid member, where each post temporarily supports an elongate electrical conductor, and at least two rotation devices for selectively controllable rotation of the rigid member and the electrically insulated support posts about at least two corresponding axes of rotation.