Patents by Inventor William Dewey

William Dewey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticle conjugated synthetic opioid prodrugs and methods of their uses
    Patent number: 11590241
    Abstract: Provided herein are nanoparticle conjugated synthetic opioid prodrugs that target the peripheral mu opioid receptor (MOR). The prodrugs exhibit long-lived bioavailability, do not compromise the analgesic effects of opioids administered for pain relief (and in some cases can be used for pain relief), and do not induce opioid withdrawal symptoms, when their use is discontinued. Certain of the prodrugs are especially useful for the prevention and/or treatment of unwanted opioid-induced side effects such as opioid-induced constipation (OIC).
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: February 28, 2023
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Hu Yang, Dana Selley, William Dewey, Hamid Akbarali
  • NANOPARTICLE CONJUGATED SYNTHETIC OPIOID PRODRUGS AND METHODS OF THEIR USES
    Publication number: 20210205472
    Abstract: Provided herein are nanoparticle conjugated synthetic opioid prodrugs that target the peripheral mu opioid receptor (MOR). The prodrugs exhibit long-lived bioavailability, do not compromise the analgesic effects of opioids administered for pain relief (and in some cases can be used for pain relief), and do not induce opioid withdrawal symptoms, when their use is discontinued. Certain of the prodrugs are especially useful for the prevention and/or treatment of unwanted opioid-induced side effects such as opioid-induced constipation (OIC).
    Type: Application
    Filed: February 17, 2017
    Publication date: July 8, 2021
    Inventors: Yan ZHANG, Hu YANG, Dana SELLEY, William DEWEY, Hamid AKBARALI
  • Potent and selective mu opioid receptor modulators
    Patent number: 10988481
    Abstract: Analogues of 6 ?/?-naltrexamine (NAQ) are provided. The analogues are selective, reversible antagonists of the mu opioid receptor (MOR) that exhibit good blood brain barrier penetration. The compounds are used in the treatment of opioid addiction and other diseases and conditions, including for the treatment of pain.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: April 27, 2021
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Dana E. Selley, William Dewey, Hamid Abkarali
  • DUAL MODULATORS OF BOTH MU AND KAPPA OPIOID RECEPTORS
    Publication number: 20190308987
    Abstract: Peripherally selective compounds that modulate both the mu opioid receptor (MOR) and the kappa opioid receptor (KOR) are provided. The compounds are substituted derivatives of 6p-N-heterocyclic naltrexamine (NAP) and are used in the treatment of diseases involving visceral pain such as irritable bowel syndrome (IBS), opioid induced constipation (OIC), and others.
    Type: Application
    Filed: May 26, 2017
    Publication date: October 10, 2019
    Inventors: Yan ZHANG, Dana SELLEY, William DEWEY, Hamid AKBARALI
  • POTENT AND SELECTIVE MU OPIOID RECEPTOR MODULATORS
    Publication number: 20190152982
    Abstract: Analogues of 6 ?/?-naltrexamine (NAQ) are provided. The analogues are selective, reversible antagonists of the mu opioid receptor (MOR) that exhibit good blood brain barrier penetration. The compounds are used in the treatment of opioid addiction and other diseases and conditions, including for the treatment of pain.
    Type: Application
    Filed: May 16, 2017
    Publication date: May 23, 2019
    Inventors: Yan ZHANG, Dana E. SELLEY, William DEWEY, Hamid ABKARALI
  • Non-peptidyl, potent, and selective mu opioid receptor antagonists and their use in treating opioid addiction and opioid induced constipation
    Patent number: 8980908
    Abstract: Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction, as well as in the treatment of opioid induced constipation (OIC).
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: March 17, 2015
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Dana E. Selley, William Dewey
  • NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS AND THEIR USE IN TREATING OPIOID ADDICTION AND OPIOID INDUCED CONSTIPATION
    Publication number: 20140371255
    Abstract: Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction, as well as in the treatment of opioid induced constipation (OIC).
    Type: Application
    Filed: May 27, 2014
    Publication date: December 18, 2014
    Applicant: Virginia Commonwealth University
    Inventors: Yan Zhang, Dana E. Selley, William Dewey
  • Non-peptidyl, potent, and selective mu opioid receptor antagonists
    Patent number: 8772308
    Abstract: Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: July 8, 2014
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Dana E. Selley, William Dewey
  • NON-PEPTIDYL, POTENT, AND SELECTIVE MU OPIOID RECEPTOR ANTAGONISTS
    Publication number: 20110306628
    Abstract: Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction.
    Type: Application
    Filed: January 15, 2010
    Publication date: December 15, 2011
    Inventors: Yan Zhang, Dana E. Selley, William Dewey