Patents by Inventor William Dougall

William Dougall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Screening assays for agonists or antagonists or receptor activator of NF-kappaB
    Publication number: 20050196801
    Abstract: The present invention provides methods for screening for a molecule that antagonizes or agonizes RANK activity. One aspect of the invention involves the growth of RANK responsive cells in semi-solid medium, wherein exposure to a RANK antagonist promotes colony formation. Other aspects of the invention rely on promoter/reporter constructs using RANK responsive promoters derived from the MMP-9 and TRAP genes. Additional aspects of the invention exploit the ability of RANK to activate c-src activity, F-actin ring formation and CaPO4 resorption.
    Type: Application
    Filed: April 4, 2005
    Publication date: September 8, 2005
    Applicant: Immunex Corporation
    Inventor: William Dougall
  • Screening assays for agonists or antagonists of CD40 signaling
    Publication number: 20050131648
    Abstract: The present invention provides methods for identifying a molecule that antagonizes or agonizes CD40 activity by screening for molecules that modulate the binding of NEMO and CYLD. Also provided are assays useful in screening for the binding of NEMO and CYLD and databases and methods useful for analyzing the resultant information.
    Type: Application
    Filed: January 20, 2004
    Publication date: June 16, 2005
    Inventors: Jonathan Derry, William Fanslow, William Dougall