Patents by Inventor William Douglass WRIGHT

William Douglass WRIGHT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TARGETED EPIGENETIC MODIFICATION
    Publication number: 20260201370
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins, and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the epigenetic modification of nucleic acids.
    Type: Application
    Filed: November 11, 2025
    Publication date: July 16, 2026
    Applicant: Mammoth Biosciences, Inc.
    Inventors: Yuchen GAO, Alex Tianjiun WEI, Kelsey Nicole DOCOUTO, Aaron DELOUGHERY, Wiputra Jaya HARTONO, Benjamin Julius RAUCH, Stepan TYMOSHENKO, William Douglass WRIGHT
  • EFFECTOR PROTEINS, COMPOSITIONS, SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20260174899
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins may be characterized as engineered CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the editing, detecting and/or engineering of nucleic acids.
    Type: Application
    Filed: October 17, 2025
    Publication date: June 25, 2026
    Inventors: William Douglass WRIGHT, Adam L. GARSKE, Aaron DELOUGHERY, Shiaki Arnett MINAMI, Lucas Benjamin HARRINGTON, Benjamin Julius RAUCH, Wang-Ting LU, Ishita JAIN, Siming XU, Susan Lorraine PROVIDENZA, Mark DEWITT
  • COMPOSITIONS AND METHODS FOR PRECISE EDITING OF HUMAN DYSTROPHIN
    Publication number: 20260097134
    Abstract: Disclosed herein are systems, compositions, and methods for modifying the human dystrophin gene (DMD). Systems, compositions, and methods may comprise a compact Type V CRISPR-associated (Cas) protein, an RNA-dependent DNA polymerase, and/or one or more guide nucleic acids or uses thereof. These systems, compositions, and methods may be useful for treating diseases such as Duchenne muscular dystrophy (DMD).
    Type: Application
    Filed: December 5, 2025
    Publication date: April 9, 2026
    Applicant: Mammoth Biosciences, Inc.
    Inventors: Yuchen GAO, Ning CHAI, Wiputra Jaya HARTONO, Benjamin Julius RAUCH, Aaron DELOUGHERY, Stepan TYMOSHENKO, William Douglass WRIGHT, Paula GONCALVES CERQUEIRA, Brian R. CHAIKIND, Kevin Cristopher WILKINS
  • COMPOSITIONS AND METHODS FOR THE MODIFICATION AND REGULATION OF LIVER GENE EXPRESSION
    Publication number: 20260002151
    Abstract: Provided herein are compositions, systems, and methods for modifying a human APOC3 gene, PCSK9 gene, or ANGPTL3 gene. Systems, compositions, and methods may comprise a CRISPR-associated (Cas) protein or uses thereof. Systems, compositions, and methods of the present disclosure may be useful for treatment of APOC3 associated conditions, including familial chylomicronemia syndrome (FCS) and severe hypertriglyceridemia (SHTG).
    Type: Application
    Filed: August 26, 2025
    Publication date: January 1, 2026
    Applicant: Mammoth Biosciences, Inc.
    Inventors: Raymond D. HICKEY, Sean CHEN, Ymer Leif Michael BJORNSON, Benjamin Julius RAUCH, William Douglass WRIGHT, Stepan TYMOSHENKO, Wiputra Jaya HARTONO, Aaron DELOUGHERY, Lucas Benjamin HARRINGTON, Lauren Kelli UYESAKA
  • COMPOSITIONS AND METHODS FOR MODIFYING DUX4
    Publication number: 20250295814
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins for treating DUX4 mutations. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering the DUX4 gene.
    Type: Application
    Filed: June 6, 2025
    Publication date: September 25, 2025
    Applicant: Mammoth Biosciences, Inc.
    Inventors: Renan B. SPER, Pei-Qi LIU, Wiputra Jaya HARTONO, Yuchen GAO, Jason Chen LIN, Ning CHAI, Aaron DELOUGHERY, Benjamin Julius RAUCH, Stepan TYMOSHENKO, William Douglass WRIGHT
  • FUSION PROTEINS AND USES THEREOF FOR PRECISION EDITING
    Publication number: 20250179454
    Abstract: Disclosed herein are composition and methods of modifying a target double-stranded DNA (dsDNA) molecule in a cell. Systems, compositions, and methods may comprise a CRISPR-associated (Cas) protein, an RNA-dependent DNA polymerase, and/or one or more guide nucleic acids or uses thereof.
    Type: Application
    Filed: February 4, 2025
    Publication date: June 5, 2025
    Applicant: Mammoth Biosciences, Inc.
    Inventors: Benjamin Julius RAUCH, Yuchen GAO, William Douglass WRIGHT, Stepan TYMOSHENKO, Rohan GROVER, David PAEZ-ESPINO
  • COMPOSITIONS FOR THE MODIFICATION OF THE HUMAN NRAS AND KRAS GENES
    Publication number: 20250177569
    Abstract: Provided herein are compositions, systems and methods for allele-specific editing of a target gene in a cell, comprising contacting the cell with an effector protein or a polynucleotide encoding the same, and a guide nucleic acid or a polynucleotide encoding the same. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering the NRAS or KRAS gene.
    Type: Application
    Filed: December 3, 2024
    Publication date: June 5, 2025
    Inventors: Subhadra JAYARAMAN RUKMINI, Shreyans SADANGI, Lucas Benjamin HARRINGTON, Pei-Qi LIU, Benjamin Julius RAUCH, William Douglass WRIGHT, Stepan TYMOSHENKO, Wiputra Jaya HARTONO, Aaron DELOUGHERY
  • EFFECTOR PROTEINS AND METHODS OF USE
    Publication number: 20250154505
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: October 18, 2024
    Publication date: May 15, 2025
    Inventors: Rohan GROVER, Clarissa Oriel RHINES, Aaron DELOUGHERY, Benjamin Julius RAUCH, William Douglass WRIGHT, David PAEZ-ESPINO, Lucas Benjamin HARRINGTON
  • ENGINEERED CAS-PHI PROTEINS AND USES THEREOF
    Publication number: 20250145974
    Abstract: Provided herein are compositions, systems, and methods comprising engineered effector proteins and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: November 6, 2024
    Publication date: May 8, 2025
    Inventors: Wiputra Jaya HARTONO, Pei-Qi LIU, Lucas Benjamin HARRINGTON, Aaron DELOUGHERY, William Douglass WRIGHT, Stepan TYMOSHENKO, Benjamin Julius RAUCH
  • EFFECTOR PROTEINS, COMPOSITIONS, SYSTEMS, DEVICES, KITS AND METHODS OF USE THEREOF
    Publication number: 20250101498
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: April 23, 2024
    Publication date: March 27, 2025
    Inventors: William Douglass WRIGHT, Stepan TYMOSHENKO, David PAEZ-ESPINO, Ashley Dorothy AMADO, Janice Sha CHEN, James Paul BROUGHTON, Xin MIAO, Sara ANSALONI, Yining ZHANG, Sierra Hirose LEE, Ryan HONG
  • PROGRAMMABLE NUCLEASES AND METHODS OF USE
    Publication number: 20250066797
    Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.
    Type: Application
    Filed: May 23, 2024
    Publication date: February 27, 2025
    Inventors: Lucas Benjamin HARRINGTON, William Douglass WRIGHT, Pei-Qi LIU, Benjamin Julius RAUCH, Wiputra Jaya HARTONO, Bridget Ann Paine MCKAY, Danuta Sastre PHIPPS, Yuxuan ZHENG, Nerea SANVISENS, Sean CHEN, David PAEZ-ESPINO
  • EFFECTOR PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF FOR MANUFACTURING ENGINEERED HSCS
    Publication number: 20240366678
    Abstract: Provided herein are compositions, systems, and methods for engineering hematopoietic stem cells that engineered by using polypeptides, such as effector proteins, and guide nucleic acids. Also, provided herein are the engineered hematopoietic stem cells, methods of manufacturing such hematopoietic stem cells, and methods of treating a disease or disorder using such hematopoietic stem cells.
    Type: Application
    Filed: May 2, 2024
    Publication date: November 7, 2024
    Inventors: Mark Alan DEWITT, Siming XU, William Douglass WRIGHT, Stepan TYMOSHENKO, Benjamin Julius RAUCH, Wiputra Jaya HARTONO, Aaron DELOUGHERY, Lucas Benjamin HARRINGTON
  • EFFECTOR PROTEINS AND METHODS OF USE
    Publication number: 20240327810
    Abstract: The present disclosure provides compositions of effector proteins. The compositions may comprise engineered guide nucleic acids. Also disclosed are the methods and systems for detecting and modifying target nucleic acids using the same. The compositions may provide nucleic acid modification and/or detection at relatively high temperatures.
    Type: Application
    Filed: November 3, 2023
    Publication date: October 3, 2024
    Inventors: James Paul BROUGHTON, Janice Sha Chen, Jesus Ching, Clare Louise Fasching, Lucas Benjamin Harrington, Lior Kreindler, Bridget Ann Paine Mckay, David Paez-Espino, Benjamin Julius Rauch, Matthew Verosloff, William Douglass Wright
  • Effector proteins and methods of use
    Patent number: 12077775
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Grant
    Filed: June 12, 2023
    Date of Patent: September 3, 2024
    Assignee: Mammoth Biosciences, Inc.
    Inventors: Aaron Deloughery, Matan Drory Retwitzer, Lucas Benjamin Harrington, Wiputra Jaya Hartono, Alexander Richard Neckelmann, David Paez-Espino, Benjamin Julius Rauch, Clarissa Oriel Rhines, Stepan Tymoshenko, Fnu Yunanda, William Douglass Wright
  • PROGRAMMABLE NUCLEASES AND METHODS OF USE
    Publication number: 20240191281
    Abstract: The present disclosure provides compositions and methods of use for a Type VI CRISPR/Cas nuclease. Type VI CRISPR/Cas nucleases are able to bind to a target nucleic acid, thereby activating trans-collateral nuclease activity on nucleic acid reports. Furthermore, the present disclosure provides methods to modify ribonucleic acid sequences using the programmable nucleases disclosed herein.
    Type: Application
    Filed: August 2, 2023
    Publication date: June 13, 2024
    Inventors: Benjamin Julius RAUCH, Aaron DELOUGHERY, Matan DRORY RETWITZER, David PAEZ-ESPINO, Caleb TRECAZZI, Lucas Benjamin HARRINGTON, Janice Sha CHEN, James Paul BROUGHTON, Clarissa Oriel RHINES, William Douglass WRIGHT, Matthew VEROSLOFF, Carley Gelenter HENDRIKS
  • ENHANCED GUIDE NUCLEIC ACIDS AND METHODS OF USE
    Publication number: 20240191280
    Abstract: The present disclosure describes CRISPR/Cas proteins and guide RNA combinations that are capable of modifying nucleic acids at high temperatures. These compositions are especially useful for systems and methods of nucleic acid detection, including diagnostic devices.
    Type: Application
    Filed: November 10, 2023
    Publication date: June 13, 2024
    Inventors: William Douglass WRIGHT, Benjamin Julius RAUCH, Aaron DELOUGHERY, James Paul BROUGHTON
  • EFFECTOR PROTEINS AND METHODS OF USE
    Publication number: 20240175059
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Application
    Filed: December 4, 2023
    Publication date: May 30, 2024
    Inventors: Aaron DELOUGHERY, Matan Drory Retwitzer, Lucas Benjamin Harrington, Wiputra Jaya Hartono, Alexander Richard Neckelmann, David Paez-Espino, Benjamin Julius Rauch, Clarissa Oriel Rhines, Stepan Tymoshenko, Fnu Yunanda, William Douglass Wright
  • PROGRAMMABLE NUCLEASES AND METHODS OF USE
    Publication number: 20240173433
    Abstract: The present disclosure provides compositions and methods of use for Type V CRISPR/Cas proteins. Type V CRISPR/Cas proteins may be configured to bind and modify nucleic acids in a sequence specific manner.
    Type: Application
    Filed: October 4, 2023
    Publication date: May 30, 2024
    Inventors: Benjamin Julius RAUCH, Aaron Deloughery, William Douglass Wright, David Paez-Espino
  • Effector proteins and methods of use
    Patent number: 11814620
    Abstract: Provided herein are compositions, systems, and methods comprising effector proteins and uses thereof. These effector proteins are shown to be active with guide RNAs and may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure leverage the activities of these effector proteins for the modification, detection, and engineering of nucleic acids.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: November 14, 2023
    Assignee: Mammoth Biosciences, Inc.
    Inventors: Benjamin Julius Rauch, Aaron DeLoughery, William Douglass Wright, David Paez-Espino, Clarissa Oriel Rhines, Lucas Benjamin Harrington, Wiputra Jaya Hartono
  • PROGRAMMABLE NUCLEASES AND METHODS OF USE
    Publication number: 20230357735
    Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.
    Type: Application
    Filed: June 3, 2021
    Publication date: November 9, 2023
    Inventors: Lucas Benjamin HARRINGTON, William Douglass WRIGHT, Pei-Qi LIU, Benjamin Julius RAUCH, Wiputra Jaya HARTONO, Bridget Ann Paine MCKAY, Danuta Sastre PHIPPS, Yuxuan ZHENG, Nerea SANVISENS, Sean CHEN, David PAEZ-ESPINO