Abstract: An array of antennae includes a monobit transmitter to insert dither into a transmit signal to form a dithered transmit signal. Monobit receivers process received signals that are combined with the dithered transmit signal to form composite received signals. Digital down converters process the composite received signals to form down converted received signals. A beamformer circuit processes the down converted received signals to form recovered signals.

Abstract: An array of antennae includes a monobit transmitter to insert dither into a transmit signal to form a dithered transmit signal. Monobit receivers process received signals that are combined with the dithered transmit signal to form composite received signals. Digital down converters process the composite received signals to form down converted received signals. A beam former circuit processes the down converted received signals to form recovered signals.

Abstract: An array of antennae includes a monobit transmitter to insert dither into a transmit signal to form a dithered transmit signal. Monobit receivers process received signals that are combined with the dithered transmit signal to form composite received signals. Digital down converters process the composite received signals to form down converted received signals. A beam former circuit processes the down converted received signals to form recovered signals.

Abstract: Provided herein are novel small molecule pyridomyrimidone viral inhibitor agents of Formula (I), such as 4-acetyl-2,3,7,8-tetrahydro-3-phenylpyrido[1,2-f]pyrimidin-1-one, and methods of using pharmaceutical or therapeutic compositions comprising such viral inhibitor agents of Formula (I) in inhibiting and treating viral infections including orthopox and retroviral infections. Methods of synthesizing such agents are also provided herein.

Abstract: Provided herein are novel small molecule pyridomyrimidone viral inhibitor agents of Formula (I), such as 4-acetyl-2,3,7,8-tetrahydro-3-phenylpyrido[1,2-f]pyrimidin-1-one, and methods of using pharmaceutical or therapeutic compositions comprising such viral inhibitor agents of Formula (I) in inhibiting and treating viral infections including orthopox and retroviral infections. Methods of synthesizing such agents are also provided herein.

Abstract: Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.

Abstract: A closure housing includes several housings. At least one of the housings is a concave housing with an open face. At least one layer, such as for example an elastomeric film or conformable sealant, is mounted on a circumferential perimeter portion of the concave housings across the open face of each of the concave housings. At least one layer, such as an elastomeric film, is adapted to interface one or more cables when the cables are interposed between the housings.

Abstract: Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is expressed from a heterologous nucleic acid borne by the package, and one or more antibodies complexed with the expressed protein and which have an open binding site for a target protein. Thus, a segment of the nucleic acid encodes for an epitope that is shared by the expressed polypeptide and the target protein. The reagents can be utilized individually or as part of a library or an array to bind target proteins within protein samples to form one or more complexes. By determining the sequence of the segment of the heterologous nucleic acid of a package within a complex, one can identify the target protein since the segment encodes for an epitope that is shared by the expressed and target proteins.

Abstract: Methods of treating a disease in a patient, methods of determining the presence of a disease in a patient, methods of determining whether a disease in a patient is suitable to be treated with a therapeutic agent, and methods of monitoring treatment of a disease in a patient comprising determining a level of expression of a transporter in cells of a tissue associated with the disease are disclosed. The methods include administering to a patient a diagnostic conjugate and/or therapeutic conjugate that are substrates for a transporter expressed by cells of a tissue associated with the disease. Kits comprising a diagnostic composition comprising a diagnostic conjugate that is a transporter substrate are also disclosed. In particular, methods and kits useful for diagnosing and treating cancer are disclosed.

Abstract: A microreplicated article is disclosed. The article includes a web including first and second opposed surfaces. The first surface includes a first microreplicated structure having a plurality of first features. The second surface includes a second microreplicated structure having a plurality of second features. Corresponding opposed features cooperate to form a lens features.

Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

Abstract: An apparatus for casting a patterned surface on both sides of a web. The apparatus includes a first patterned roll; a second pattered roll; and a means for rotating the first and second patterned rolls such that their patterns are transferred to opposite sides of the web while it is in continuous motion. During this process, their patterns are maintained in continuous registration to within at least 100 microns, and preferably at least 20 microns.

Abstract: Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid substrate.

Abstract: Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen a library of compounds for a desired biological activity are also provided, especially assays for compounds that are substrates for receptor-mediated transport processes such as endocytosis and transcytosis.

Abstract: Microlens sheetings with composite images are disclosed, in which the composite image floats above or below the sheeting, or both. The composite image may be two-dimensional or three-dimensional. Methods for providing such an imaged sheeting are also disclosed.

Abstract: A method of making a sealant material, such as a grease material, which includes providing a diblock copolymer, where the diblock copolymer includes a plurality of styrene zones and a plurality of rubber zones, and where the styrene zones have a glass transition temperature, and combining the diblock copolymer with mineral oil at a processing temperature less than about the glass transition temperature of the styrene zones. Also disclosed are such sealant and gel materials.

Abstract: An electrical connector assembly comprises a connector block, which includes a plurality of housing assemblies aligned in a generally vertically stacked orientation. Each housing assembly comprises a housing, an insulation displacement connector element disposed within the housing, where the insulation displacement connector element is adapted to electrically connect with a conductor partially disposed within the housing, an access cover, where the access cover is connected to the housing and is moveable between a closed position and an open position, wherein in the open position, the insulation displacement connector disposed within the housing is accessible, a generally vertical surface, and a conductor-receiving opening along the generally vertical surface.

Abstract: A microreplicated article is disclosed. The article includes an opaque web having first and second opposed surfaces. The first surface includes a first microreplicated structure having a plurality of first features. The second surface includes a second microreplicated structure having a plurality of second features. The first microreplicated structure and the second microreplicated structure retain registration within 100 micrometers.

Abstract: The present invention is a method of using a sealant material, which includes providing the sealant material, where the sealant material comprises mineral oil, petroleum wax, and a viscosity builder, and where the sealant material exhibits a first hardness. The viscosity builder is selected from a group consisting of polybutene, a styrene-rubber diblock copolymer, an ethylene-propylene oligomer, and combinations thereof. The method also includes applying a shear force to at least a first portion of the sealant material, where the first portion of the sealant material exhibits a second hardness after the shear force is applied, and where the first hardness is at least two times greater than the second hardness.

Abstract: An apparatus for casting a patterned surface on both sides of an opaque web. The apparatus includes a first patterned roll, a second pattered roll, and a means for rotating the first and second patterned rolls such that their patterns are transferred to opposite sides of the opaque web while it is in continuous motion. During this process, their patterns are maintained in continuous registration to within at least 100 micrometers.