Patents by Inventor William Downey

William Downey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170073359
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Application
    Filed: September 26, 2016
    Publication date: March 16, 2017
    Inventors: Schuyler CORRY, William DOWNEY, Brian FILANOSKI, Kyle GEE, Lawrence GREENFIELD, James HIRSCH, Iain JOHNSON, Aleksey RUKAVISHNIKOV
  • Publication number: 20160139135
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Application
    Filed: September 11, 2014
    Publication date: May 19, 2016
    Inventors: Schuyler CORRY, William Downey, Brian Filanoski, Kyle Gee, Lawrence Greenfield, James Hirsch, Iain Johnson, Aleksey Rukavishnikov
  • Patent number: 8865891
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactamase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactamase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactamase or instructions for using the components in an assay.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: October 21, 2014
    Assignee: Life Technologies Corporation
    Inventors: Schuyler Corry, William Downey, Brian Filanoski, Kyle Gee, Lawrence Greenfield, James Hirsch, Iain Johnson, Aleksey Rukavishnikov
  • Publication number: 20130090470
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Application
    Filed: September 13, 2012
    Publication date: April 11, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Schuyler CORRY, William Downey, Brian Filanoski, Kyle Gee, Lawrence Greenfield, James Hirsch, Iain Johnson, Aleksey Rukavishnikov
  • Patent number: 8318450
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: November 27, 2012
    Assignee: Life Technologies Corporation
    Inventors: Schuyler Corry, William Downey, Brian Filanoski, Kyle Gee, Lawrence Greenfield, James Hirsch, Iain Johnson, Aleksey Rukavishnikov
  • Publication number: 20070157675
    Abstract: A recovery system recycles the washwater used to clean excess binder and debris from the production components, including a forming hoodwall constructed of non-corrosive materials, for manufacturing fiberglass insulation. A separate closed-loop recovery system is provided for the forming hoodwall in which the binder-containing washwater is screened and then recycled back to the forming hoodwall without further chemical treatment to change the pH level. A binder reclamation system is coupled to the hoodwall washwater recovery system to divert the low pH washwater when the supply of binder needs replenished at the forming hoodwall. The binder reclamation system introduces an acid solution to the cleaned washwater to lower the pH from about 2.5 to about 3.5. The other production components share a bulk washwater recovery system in which a base solution is introduced to raise the pH to approximately 8 or above to reduce corrosion in the other production components.
    Type: Application
    Filed: February 26, 2007
    Publication date: July 12, 2007
    Inventors: Harry Cline, William Downey, Liang Chen, William Cooper
  • Publication number: 20070000517
    Abstract: A neutralization system for controlling the pH of the washwater used to clean and maintain polyacrylic bound glass forming equipment is provided. The neutralization system introduces a base solution to a washwater solution when the pH of the washwater solution contained in a closed loop washwater recovery system and in a washwater tank holding the washwater solution is determined to be below approximately 8.0. Maintaining the pH of the washwater solution reduces the corrosion rate of the glass fiber forming equipment that is typically associated with acidic binders. In a second embodiment of the invention, a closed-loop hoodwall reclaim washwater recovery system utilized in addition to the washwater neutralization system that allows for the recovery and reuse of a polycarboxylic acid binder with a minimal amount of base solution. The closed-loop hoodwall reclaim washwater system is not connected to the closed-loop washwater neutralization system.
    Type: Application
    Filed: May 23, 2006
    Publication date: January 4, 2007
    Inventors: Harry Cline, William Downey, Liang Chen, William Cooper
  • Publication number: 20050227309
    Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.
    Type: Application
    Filed: January 21, 2005
    Publication date: October 13, 2005
    Inventors: Schuyler Corry, William Downey, Brian Filanoski, Kyle Gee, I. Greenfield, James Hirsch, Iain Johnson, Aleksey Rukavishnikov
  • Publication number: 20050218285
    Abstract: A portable holder for storing air guns and other hand tools is disclosed. In a preferred embodiment, the holder comprises: a generally-tubular body having two open ends, one of which is flared; a slit or gullet on one side of the body and extending longitudinally from the flared open end of the body partway down the body; and a plurality of magnetic discs or feet for removably, yet securely attaching the holder to a workstation having a ferrous surface. A related process for storing such tools comprises: orienting a generally tubular holder adjacent a workstation's metal side; removably affixing the holder to that metal surface by at least one magnet; slipping the particular tool into a flared end of the holder; and guiding a portion of the tool, such as an attached air hose or the tool handle, into a gullet of the holder to rest the tool and orient the hose or handle for easy retrieval of the tool from the holder.
    Type: Application
    Filed: March 23, 2005
    Publication date: October 6, 2005
    Applicant: GUARDAIR CORPORATION
    Inventors: Mark Yorns, Thomas Tremblay, Brian Donovan, James Fletcher, William Downey
  • Patent number: 6933349
    Abstract: A binder composition, obtained by polymerizing acrylic acid monomer in water in the presence of a cure accelerator comprising an alkali metal salt of a phosphorous-containing inorganic acid to form a low molecular weight polyacrylic acid and subsequently reacting said low molecular weight polyacrylic acid with a polyhydroxy crosslinking agent in a crosslinking step to make a composition suitable for use as a component in a binder for fiberglass. A significant improvement involves conducting the crosslinking step in the absence of added catalyst. Moreover, satisfactory results are obtained in the absence of conventional undesirable sulfur odors.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: August 23, 2005
    Assignee: Owens Corning Fiberglas Technology, Inc.
    Inventors: Liang Chen, William Downey
  • Publication number: 20050095937
    Abstract: A binder composition, obtained by polymerizing acrylic acid monomer in water in the presence of a cure accelerator comprising an alkali metal salt of a phosphorous-containing inorganic acid to form a low molecular weight polyacrylic acid and subsequently reacting said low molecular weight polyacrylic acid with a polyhydroxy crosslinking agent in a crosslinking step to make a composition suitable for use as a component in a binder for fiberglass. A significant improvement involves conducting the crosslinking step in the absence of added catalyst. Moreover, satisfactory results are obtained in the absence of conventional undesirable sulfur odors.
    Type: Application
    Filed: November 2, 2004
    Publication date: May 5, 2005
    Inventors: Liang Chen, William Downey
  • Publication number: 20050076987
    Abstract: An apparatus for monitoring a condition of a tire, such as tread belt separation, includes at least one sound monitoring device that is carried by a vehicle. The sound monitoring device produces a sound monitoring device output signal that is representative of the sound produced by at least one of the tires during rotation. A signal processing device is also present and includes a neural network. The signal processing device receives and processes the sound monitoring device output signal. A processing device output signal that is representative of a potential damage condition of the tire is produced. An indication device is present and receives the processing device output signal. The indication device informs a user of the vehicle that the tire is experiencing the potential damage condition.
    Type: Application
    Filed: October 9, 2003
    Publication date: April 14, 2005
    Inventors: George O'Brien, William Downey
  • Publication number: 20050032985
    Abstract: A binder composition, obtained by polymerizing acrylic acid monomer in water in the presence of a cure accelerator comprising an alkali metal salt of a phosphorous-containing inorganic acid to form a low molecular weight polyacrylic acid and subsequently reacting said low molecular weight polyacrylic acid with a polyhydroxy crosslinking agent in a crosslinking step to make a composition suitable for use as a component in a binder for fiberglass. A significant improvement involves conducting the crosslinking step in the absence of added catalyst Moreover, satisfactory results are obtained in the absence of conventional undesirable sulfur odors.
    Type: Application
    Filed: July 14, 2004
    Publication date: February 10, 2005
    Inventors: Liang Chen, William Downey, Richard Dobrowolski
  • Publication number: 20030008978
    Abstract: A binder composition, obtained by polymerizing acrylic acid monomer in water in the presence of a cure accelerator comprising an alkali metal salt of a phosphorous-containing inorganic acid to form a low molecular weight polyacrylic acid and subsequently reacting said low molecular weight polyacrylic acid with a polyhydroxy crosslinking agent in a crosslinking step to make a composition suitable for use as a component in a binder for fiberglass. A significant improvement involves conducting the crosslinking step in the absence of added catalyst. Moreover, satisfactory results are obtained in the absence of conventional undesirable sulfur odors.
    Type: Application
    Filed: March 21, 2001
    Publication date: January 9, 2003
    Inventors: Liang Chen, William Downey
  • Patent number: 6171822
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for stanniocalcin-2, a novel member of the stanniocalcin family. The polypeptides, and polynucleotides encoding them, modulate electrolyte homeostasis. The present invention also includes antibodies to the stanniocalcin-2 polypeptides.
    Type: Grant
    Filed: October 11, 1999
    Date of Patent: January 9, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: Rolf E. Kuestner, Darrell C. Conklin, Si Lok, Michele Buddle, William Downey
  • Patent number: 6008322
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for stanniocalcin-2, a novel member of the stanniocalcin family. The polypeptides, and polynucleotides encoding them, modulate electrolyte homeostasis. The present invention also includes antibodies to the stanniocalcin-2 polypeptides.
    Type: Grant
    Filed: April 1, 1997
    Date of Patent: December 28, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Rolf E. Kuestner, Darrell C. Conklin, Si Lok, Michele Buddle, William Downey
  • Patent number: 5744587
    Abstract: Methods of removing protein contaminants from a solution comprising thrombopoietin are disclosed. The solution is exposed to hydroxyapatite, whereby protein contaminants are bound to the hydroxyapatite and the thrombopoietin remains substantially unbound, and the unbound thrombopoietin is recovered. The use of hydroxyapatite is advantageously combined with other purification and concentration techniques, including ion-exchange chromatography, ligand affinity chromatography, hydrophobic interaction chromatography, ultrafiltration, and differential precipitation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 28, 1998
    Assignee: ZymoGenetics, Inc.
    Inventors: Andrew R. Alaska, Jin-Jyi Chang, William Downey, John W. Forstrom, Linh Phan
  • Patent number: 4642106
    Abstract: A manually manipulated implement and method of use thereof for facilitating the drainage of conventional ostomy pouches are disclosed. The implement includes a two-piece handle portion with an elongated engagement member extending from each, with hinge means connecting the handle pieces and engagement members of movement toward and away from one another between spaced and essentially contacting positions. When the pouch drain opening is positioned over a suitable receptacle, the pouch walls are placed between the elongated engagement members, which are then moved from the spaced position to engage the pouch walls firmly therebetween. The implement is then moved manually toward the drain opening, forcing the contents out of the pouch, into the receptacle. In the preferred embodiment the implement is of one-piece molded plastic construction and includes means for stabilizing the relative lateral position of the engagement members as the implement is moved along the pouch.
    Type: Grant
    Filed: February 2, 1984
    Date of Patent: February 10, 1987
    Inventor: William Downey