Patents by Inventor William Drefko

William Drefko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Binder composition and method for processing poorly compressible drugs into tablets of predetermined hardness and friability
    Patent number: 7704528
    Abstract: Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or polyol, which reduces the Tg of the copolymer by at least 10° C. The binder composition and the drug are directly compressed into a tablet of predetermined hardness and friability, and at an acceptable compression force.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: April 27, 2010
    Assignee: ISP Investments Inc.
    Inventors: Rama Haldar, John Zamora, Dipan B. Ray, William Drefko, Greg Dubrowny, Sidney Etienne
  • Process and apparatus for forming agglomerates of a powder composition of an active and binder
    Patent number: 7534381
    Abstract: A process and apparatus for forming agglomerates of a powder composition of an active and binder such as a homopolymer or copolymer which includes passing the composition through a hot roller compactor to heat said binder material above its glass transition temperature.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: May 19, 2009
    Assignee: ISP Investments Inc.
    Inventors: Rama Haldar, Dipan B. Ray, William Drefko, Sidney Etienne
  • Process and apparatus for forming agglomerates of a powder composition of an active and binder
    Publication number: 20070060494
    Abstract: A process and apparatus for forming agglomerates of a powder composition of an active and binder such as a homopolymer or copolymer which includes passing the composition through a hot roller compactor to heat said binder material above its glass transition temperature.
    Type: Application
    Filed: September 14, 2005
    Publication date: March 15, 2007
    Inventors: Rama Haldar, Dipan Ray, William Drefko, Sidney Etienne
  • Binder composition and method for processing poorly compressible drugs into tablets of predetermined hardness and friability
    Publication number: 20040224015
    Abstract: Tablets of a poorly compressible drug are made by direct compression using a binder composition which is a polymer, preferably a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate (VA), having a defined glass transition temperature (Tg), admixed with a plasticizer, e.g. an organic ester or polyol, which reduces the Tg of the copolymer by at least 10° C. The binder composition and the drug are directly compressed into a tablet of predetermined hardness and friability, and at an acceptable compression force.
    Type: Application
    Filed: August 15, 2003
    Publication date: November 11, 2004
    Applicant: ISP INVESTMENTS INC.
    Inventors: Rama Haldar, John Zamora, Dipan B. Ray, William Drefko, Greg Dubrowny, Sidney Etienne
  • Tablet coating composition
    Patent number: 6620426
    Abstract: A tablet coating composition including a mixture of (a) sodium alginate and (b) a polyvinylpyrrolidone-vinyl acetate copolymer, and, optionally, (c) hydroxypropylmethyl cellulose, and/or hydroxypropyl cellulose.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: September 16, 2003
    Assignee: ISP Investments Inc.
    Inventors: Antonio Moroni, Nadhamuni G. Nerella, William Drefko
  • Tablet coating composition
    Publication number: 20020192284
    Abstract: A tablet coating composition including a mixture of (a) sodium alginate and (b) a polyvinylpyrrolidone-vinyl acetate copolymer, and, optionally, (c) hydroxypropylmethyl cellulose, and/or hydroxypropyl cellulose.
    Type: Application
    Filed: June 5, 2001
    Publication date: December 19, 2002
    Applicant: ISP INVESTMENTS INC.
    Inventors: Antonio Moroni, Nadhamuni G. Nerella, William Drefko
  • PH-DEPENDENT SUSTAINED RELEASE, DRUG-DELIVERY COMPOSITION
    Publication number: 20020182252
    Abstract: A pH-dependent sustained release, drug delivery composition capable of being formed into tablets or pellets, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-independent non-gelling material, comprising a polymer matrix comprising, by weight, (a) 10 to 50% sodium alginate, (b) 2 to 15% propylene glycol alginate and (c) 40 to 80% of a pharmaceutical medicament.
    Type: Application
    Filed: March 21, 2001
    Publication date: December 5, 2002
    Applicant: ISP INVESTMENTS INC.
    Inventors: Antonio Moroni, William Drefko
  • pH-dependent sustained release, drug-delivery composition
    Patent number: 6465014
    Abstract: A pH-dependent sustained release, drug delivery composition capable of being formed into tablets or pellets, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-independent non-gelling material, comprising a polymer matrix comprising, by weight, (a) 10 to 50% sodium alginate, (b) 2 to 15% propylene glycol alginate and (c) 40 to 80% of a pharmaceutical medicament.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: October 15, 2002
    Assignee: ISP Investments Inc.
    Inventors: Antonio Moroni, William Drefko