Abstract: The invention relates to compositions and formulations for the treatment of disorders of the gastrointestinal (GI) tract. Also provided are methods for treating, preventing, and/or alleviating disorders of the GI tract.

Abstract: Methods, systems, and devices are described for providing network access services to mobile users via mobile terminals over a satellite system. In embodiments, dynamic multiplexing of traffic from fixed terminals and mobile users on the same satellite beam can take advantage of statistical multiplexing of large numbers of users and on different usage patterns between fixed terminals and mobile users. In embodiments, quality-of-service (QoS) is controlled for mobile devices at a per-user level. Mobile users may be provisioned on the satellite system according to a set of traffic policies based on their service level agreement (SLA). System resources of the satellite may be allocated to mobile users based on the demand of each mobile user and the set of traffic polices associated with each mobile user, regardless of which mobile terminal is used to access the system.

Abstract: A durability assessment system may receive a request, from a computing system, for a durability index describing an entity. The durability assessment system may determine the durability index based on information about the resource usage by the entity, such as a resource availability score or a resource allocation score. The durability assessment system may compare the obtained resource availability score and resource allocation score to ranges associated with a set of durability indices. Based on the comparison, the durability assessment system may determine a durability index for the entity. The durability index may indicate an ability of the entity to return accessed resources. In some cases, the durability assessment system may provide the durability index to an allocation computing system that is configured to determine whether to grant access to resources based on the durability index.

Abstract: Techniques are disclosed for automatically executing scripts for event in response to user activity within the event. A server executing a video conferencing service, receives meeting scheduling information and a set of user-specified scripting information from a user requesting to generate an event. In response to receiving a request from user device to access the event, the server causes display of an event interface to the device, the displayed interface including indications of sub-groups of a group of users accessing the conferencing service via a plurality of user devices and an indication of a video feed of a user in the group of users that is currently active. In response to one or more triggers corresponding to the event, one or more scripts are executed for the event, where executing the one or more scripts includes altering the displayed interface.

Abstract: A motorized apparatus for use in maintaining a pipe having a sidewall defining an interior cavity is provided. The motorized apparatus includes a body assembly extending along a longitudinal axis, at least one maintenance device coupled to the body assembly, and a plurality of leg assemblies coupled circumferentially around the body assembly. The motorized apparatus also includes a plurality of drive mechanisms coupled to the plurality of leg assemblies. The plurality of drive mechanisms are configured to interact with the sidewall. The plurality of drive mechanisms include at least two wheels. The plurality of drive mechanisms are arranged to move the body assembly in a first direction parallel to the longitudinal axis, move the body assembly in a second direction perpendicular to the longitudinal axis, and rotate the body assembly around the longitudinal axis.

Abstract: This disclosure presents a MITLIF procedure. The procedure uses a single incision on one side and pedicle screws are placed on that side and through the same incision a facet screw is placed on the opposite side using a series of jigs, and, for example, the hole cutter, drill, guide shaft and screw driver described herein.

Abstract: Methods, systems, computer program products and data structures are described which allow for efficient correction of a transcription output of an automatic speech recognition system by a human proofreader. A method comprises receiving a voice input from a user; determining a transcription of the voice input; providing the transcription of the voice input; receiving a text input from the user indicating a revision to the transcription; determining how to revise the transcription in accordance with the text input; and revising the transcription of the voice input in accordance with the text input. A general or specialized language model, an acoustical language model, a character language model, a gaze tracker, and/or a stylus may be used to determine how to revise the transcription in accordance with the text input.

Abstract: A refilling device for an article of an aerosol provision system comprises refilling control circuitry configured to facilitate the transfer of aerosol-generating material from a reservoir to the article in response to detecting that the article has been received by the refilling device.

Abstract: A desktop refilling device for an article of an aerosol provision system comprises an article interface configured to receive the article, a reservoir interface configured to receive a reservoir, and refilling control circuitry configured to facilitate the transfer of aerosol-generating material from the reservoir to the article, wherein the article interface and/or the reservoir interface are configured to respectively enclose the article and the reservoir inside a housing of the desktop refilling device during the transfer of aerosol-generating material from the reservoir to the article.

Abstract: A desktop refilling device for an article of an aerosol provision system comprising the article and an aerosol provision device. The desktop refilling device comprises an article interface configured to receive the article when the article is separated from the aerosol provision device, and refilling control circuitry configured to facilitate the transfer of aerosol-generating material from a reservoir couplable to the refilling device to the article.

Abstract: The present disclosure relates to a method of preventing or treating a cancer via administering an EHMT2 inhibitor or a combination comprising an EHMT2 inhibitor compound and one or more additional therapeutic agent disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds or combinations for research or other non-therapeutic purposes.

Abstract: The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Abstract: A method, system, apparatus and computer program product are disclosed for enhancing operable functionality of xAPI statements by sequentially comparing a plurality of authorized xAPI statements against a plurality of trigger rules with a pattern matching process which evaluates matching xAPI data properties and logical and/or comparative operator requirements from each trigger rule against each authorized xAPI statement to identify matching trigger rules which are evaluated against one or more required trigger rules associated with a first trigger to automatically generate one or more outbound REST API calls to communicate with a third-party application upon detecting that the all the required trigger rules associated with the first trigger are matched by an actor.

Abstract: The is provided a computer-implemented method for generating a quantum circuit from a Unitary Coupled Cluster (UCC) Ansatz, wherein the Ansatz represents an excitation of a reference state by a parameterised operator including excitation operators, and wherein the Ansatz includes multi-qubit Pauli operators that are determined from each excitation operator. The method comprises: partitioning the Pauli operators into mutually commuting sets and sequencing the Pauli operators by set; generating Pauli gadgets from the Pauli operators by Trotterization, wherein the Pauli gadgets have a same sequencing by set as the Pauli operators; diagonalising each set of Pauli gadgets to convert the Pauli gadgets into phase gadgets; and transforming the phase gadgets into one- and two-qubit native gates to generate the quantum circuit. Moreover, there is also provided a system that is configured to implement the method.

Abstract: The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

Abstract: The present disclosure relates to a method of preventing or treating a cancer via administering an EHMT2 inhibitor or a combination comprising an EHMT2 inhibitor compound and one or more additional therapeutic agent disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds or combinations for research or other non-therapeutic purposes.

Abstract: The present disclosure relates to a method of preventing or treating an imprinting disorder via administering an EHMT2 inhibitor compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Abstract: In non-limiting examples of the present disclosure, systems, methods and devices for integrating speech-to-text transcription in a productivity application are presented. A request to access a real-time speech-to-text transcription of an audio signal that is being received by a second device is sent by a first device. The real-time speech-to-text transcription may be surfaced in a transcription pane of a productivity application on the first device. A request to translate the transcription to a different language may be received. The transcription may be translated in real-time and surfaced in the transcription pane. A selection of a word in the surfaced transcription may be received. A request to drag the word from the transcription pane and drop it in a window in the productivity application outside of the transcription pane may be received. The word may be surfaced in the window in the productivity application outside of the transcription pane.

Abstract: This disclosure generally relates to pyridine-2-one compounds of formula (I) and methods of using them in the treatment of a disorder, such as cancer or a SMARCA2-associated disorder, including as antagonists (e.g., inhibitors) of SMARCA2. The present disclosure provides treatment modalities, e.g., strategies, treatment methods, patient stratification methods, compounds, combinations, and compositions that are useful for the treatment of disorders, e.g., proliferative disorders, such as certain cancers. Some aspects of this disclosure provide treatment modalities, methods, strategies, compounds, compositions, combinations, and dosage forms for the treatment of cell proliferative disorders, e.g., cancers with decreased activity or function, or loss of function, of SMARCA4 with a SMARCA2 antagonist.

Abstract: The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.