Patents by Inventor William E. Brewer

William E. Brewer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220184525
    Abstract: A device for automated or manual group separations of complex biological mixtures and methods of use are described. The device is a gel filtration pipette tip having a size exclusion media therein and held in place by a filter at the distal end of the pipette tip and an optional removable or pierceable barrier at the proximal end of the pipette tip. The size exclusion media is wetted by aspirating a solvent from the bottom of the pipette tip and equilibrating the solvent with the size exclusion media. The solvent is then allowed to gravity drain from the pipette tip, allowing the size exclusion media to settle and reproducibly pack into a homogenous gel. Gel filtration separations can then be performed with the gelled size exclusion media.
    Type: Application
    Filed: March 2, 2022
    Publication date: June 16, 2022
    Inventors: William E. BREWER, Matthew G. FITTS
  • Publication number: 20220088537
    Abstract: A device for filtration or extraction using at least one filtration membrane is disclosed. The device is shaped like a Buchner funnel, but small enough to fit with wide bore pipette tips, slip tip syringes or an adaptor of a robotic liquid handler or pipettor. It also houses one or more filtration membranes and or a separation resin. A reservoir adaptor can be added to the top in a fluid tight manner to provide a removable large volume container where needed for larger samples, and a gasket adaptor allows the reservoir to be connected to other devices in a fluid tight manner.
    Type: Application
    Filed: September 12, 2021
    Publication date: March 24, 2022
    Inventors: William E. BREWER, Matthew G. FITTS
  • Patent number: 11193930
    Abstract: Devices and methods for performing pre-analysis sample processing of biological and chemical samples using robotic liquid handlers are disclosed. Methods for solid phase extraction, protein precipitation and filtration of biological and chemical samples using automation and the devices in a rapid and convenient way are described.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: December 7, 2021
    Assignee: DPX TECHNOLOGIES, LLC
    Inventors: William E. Brewer, Kaylee R. Mastrianni
  • Publication number: 20210373006
    Abstract: Devices and methods for performing pre-analysis sample processing of biological and chemical samples using robotic liquid handlers are disclosed. Methods for solid phase extraction, protein precipitation and filtration of biological and chemical samples using automation and the devices in a rapid and convenient way are described.
    Type: Application
    Filed: August 16, 2021
    Publication date: December 2, 2021
    Inventors: William E. BREWER, Kaylee R. MASTRIANNI
  • Publication number: 20200025755
    Abstract: Devices and methods for performing pre-analysis sample processing of biological and chemical samples using robotic liquid handlers are disclosed. Methods for solid phase extraction, protein precipitation and filtration of biological and chemical samples using automation and the devices in a rapid and convenient way are described.
    Type: Application
    Filed: August 2, 2017
    Publication date: January 23, 2020
    Inventors: William E. BREWER, Kaylee R. MASTRIANNI
  • Patent number: 9733169
    Abstract: A pipette tip device for use in dispersive SPE. The device includes a pipette tip having a lower barrier, loose sorbent that is freely moveable during the extraction process, and a baffle system that is shaped to disrupt the flow of liquid sample that is aspirated into the pipette tip. The baffle system includes an insert that may be separate from or monolithic with the interior of the pipette tip.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: August 15, 2017
    Inventor: William E. Brewer
  • Publication number: 20150011016
    Abstract: A pipette tip device for use in dispersive SPE. The device includes a pipette tip having a lower barrier, loose sorbent that is freely moveable during the extraction process, and a baffle system that is shaped to disrupt the flow of liquid sample that is aspirated into the pipette tip. The baffle system includes an insert that may be separate from or monolithic with the interior of the pipette tip.
    Type: Application
    Filed: February 14, 2013
    Publication date: January 8, 2015
    Inventor: William E. Brewer
  • Patent number: 6566145
    Abstract: The present invention is a disposable apparatus for the rapid, low-volume solid phase extraction of analytes from a variety of sources. The apparatus of the present invention is configured as a pipette tip and contains a loosely confined stationary phase. The mobility of the stationary phase particles enables rapid mixing and equilibration with a sample solution during agitation. The analyte may thereby be extracted in less time with less solvent, removing the need for a separate concentration step.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: May 20, 2003
    Inventor: William E Brewer
  • Publication number: 20020009809
    Abstract: The present invention is a disposable apparatus for the rapid, low-volume solid phase extraction of analytes from a variety of sources. The apparatus of the present invention is configured as a pipette tip and contains a loosely confined stationary phase. The mobility of the stationary phase particles enables rapid mixing and equilibration with a sample solution during agitation. The analyte may thereby be extracted in less time with less solvent, removing the need for a separate concentration step.
    Type: Application
    Filed: February 9, 2001
    Publication date: January 24, 2002
    Inventor: William E. Brewer
  • Patent number: 5762877
    Abstract: The present invention advances a chemical concentrating device for use with thin layer chromatographic, gas chromatographic, high pressure liquid chromatographic, and capillary electrophoresis analysis. The concentrating device has a T-shaped member having a first and second annular branch in axial alignment and a third branch perpendicular to the first and second branches. When used in thin layer chromatographic analysis, the T-shaped member is placed over the syringe needle with the end of the needle extending below the second branch. A gas source in fluid communication with the third branch forwards gas in an annular pattern about the end of the needle, thereby evaporating the solvent within the sample and confining the sample to a particular geometrical area on the thin layer chromatography plate. When used with other chromatographic techniques, the T-shaped member is removably affixed to a syringe needle having a beveled end.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: June 9, 1998
    Inventor: William E. Brewer
  • Patent number: 4062195
    Abstract: The invention relates to a controlled density fill material and a method of using such fill material in, for examples, the backfilling of sewers, embankments, structures and utility trenches. The material includes Portland cement, fly ash and aggregates. The material, while having some properties of both, is neither a soil nor a concrete.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: December 13, 1977
    Assignee: K-Krete, Inc.
    Inventors: William E. Brewer, Franklin V. Zimmer
  • Patent number: 4050950
    Abstract: The invention relates to a controlled density fill material and a method of using such fill material in, for examples, the backfilling of sewers, embankments, structures and utility trenches. The material includes Portland cement, fly ash and aggregates. The material, while having some properties of both, is neither a soil nor a concrete.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: September 27, 1977
    Assignee: K-Krete, Inc.
    Inventors: William E. Brewer, Franklin V. Zimmer
  • Patent number: 4050261
    Abstract: The invention relates to a controlled density fill material and a method of using such fill material in, for examples, the backfilling of sewers, embankments, structures and utility trenches. The material includes Portland cement, fly ash and aggregates. The material, while having some properties of both, is neither a soil nor a concrete.
    Type: Grant
    Filed: June 3, 1974
    Date of Patent: September 27, 1977
    Assignee: K-Krete, Inc.
    Inventors: William E. Brewer, Franklin V. Zimmer
  • Patent number: 4050258
    Abstract: The invention relates to a controlled density fill material and a method of using such fill material in, for examples, the backfilling of sewers, embankments, structures and utility trenches. The material includes Portland cement, fly ash and aggregates. The material, while having some properties of both, is neither a soil nor a concrete.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: September 27, 1977
    Assignee: K-Krete, Inc.
    Inventors: William E. Brewer, Franklin V. Zimmer
  • Patent number: D782693
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: March 28, 2017
    Assignee: DPX Technologies, LLC
    Inventors: William E. Brewer, Robert S. Earnhardt, Jr., Lim Andrew Lee