Patents by Inventor William E. Grieshober

William E. Grieshober has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11166451
    Abstract: A method for platelet preservation comprising placing a composition comprising platelets in a gas mixture comprising xenon and oxygen under pressure of about 0-10 Bars at a first temperature of about 18° C.-37° C. for a first period of time, and then subsequently cooling the composition to a second temperature of about 0,1° C.-6° C., and holding the composition under the pressure and in the second temperature for a second period of time.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: November 9, 2021
    Assignee: Rich Technologies Holding Company, LLC
    Inventors: Ilya Ilyin, Semyon Kogan, William E. Grieshober, Jr., James S. Jones, Alexander N. Shumeev, Stanislav A. Kolchanov, Yana A. Filkina, Yuriy Punin, Natella I. Enukashvily
  • Patent number: 10412957
    Abstract: A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: September 17, 2019
    Assignee: Rich Technologies Holding Company, LLC
    Inventors: Ilya Ilyin, Semyon Kogan, William E. Grieshober, Jr., Igor Kachko, Vladimir Vasiliev, Stanislav Kolchanov, Yuriy Punin, Mark Bakhrakh, Alexander N. Schumeev
  • Patent number: 10098340
    Abstract: Provided is a method for reducing apoptosis in nucleated cells. The method entails holding nucleated cells in a container and adding a gas containing xenon to the container so that the pressure inside the container reaches between 0.5 to 4.0 Atm above ambient pressure; holding the container at between 0.5 to 4.0 Atm above ambient pressure for a period of time during which the temperature in the container is between 22° C. and 37° C.; lowering the temperature in the container to between 0.1° C. and 10° C. while maintaining the pressure of 0.5 to 4.0 Atm above ambient pressure and holding the container for a period of time; and reducing the pressure in the container to ambient pressure and increasing the temperature to 22° C.-37° C. By performing these steps, the cells undergo less apoptosis than a reference.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: October 16, 2018
    Assignee: Rich Technologies Holding Company, LLC
    Inventors: William E. Grieshober, Jr., James S. Jones, Semyon Kogan, Ilya Ilyin, Natella I. Enukashvily, Yana A. Filkina, Alexander N. Shumeev, Stanislav Kolchanov
  • Patent number: 9743660
    Abstract: A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: August 29, 2017
    Assignee: Rich Technologies Holding Company, LLC
    Inventors: Ilya Ilyin, Semyon Kogan, William E. Grieshober, Jr., Igor Kachko, Vladimir Vasiliev, Stanislav A. Kolchanov, Yuriy Punin, Mark Bakhrakh, Alexander N. Shumeev
  • Publication number: 20170127666
    Abstract: A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.
    Type: Application
    Filed: January 24, 2017
    Publication date: May 11, 2017
    Inventors: Ilya Ilyin, Semyon Kogan, William E. Grieshober, Jr., Igor Kachko, Vladimir Vasiliev, Stanislav Kolchanov, Yuriy Punin, Mark Bakhrakh, Alexander N. Schumeev
  • Patent number: 8870035
    Abstract: A dispensing device having a housing capable of receiving a pre-packaged charge of pre-whipped topping or icing. The housing has an inner wall with a slot formed therein for receiving a rack that is capable of rotational and translational motion within the slot. The rack has a set of gear teeth that engage with a catch on a plunger. The piston moves in the axial direction to force the pre-whipped topping or icing through the outlet in its packaging. The catch on the piston is locked in one direction and pivots in the opposite direction such that the rack engages with the piston when it moves in a first direction and the rack disengages with the piston when it is moved in a second direction opposite the first direction.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: October 28, 2014
    Assignee: Rich Products Corporation
    Inventors: Rohit Jalali, Christopher Vincent Tirone, Theodore Watson Rich, Steven A. Franz, William E. Grieshober, Jr., Joseph Victor Bisacca, Lisa Augustine, Kerry Marshal Chace, Timothy A. Falken, David E. Moomaw
  • Publication number: 20140227678
    Abstract: A method for platelet preservation comprising placing a composition comprising platelets in a gas mixture comprising xenon and oxygen under pressure of about 0-10 Bars at a first temperature of about 18° C.-37° C. for a first period of time, and then subsequently cooling the composition to a second temperature of about 0,1° C.-6° C., and holding the composition under the pressure and in the second temperature for a second period of time.
    Type: Application
    Filed: September 26, 2012
    Publication date: August 14, 2014
    Applicant: Advanced Preservations Technologies, LLC
    Inventors: Ilya Ilyin, Semyon Kogan, William E. Grieshober, JR., James S. Jones, Alexander N. Shumeev, Stanislav A. Kolchanov, Yana A. Filkina, Yuriy Punin, Natella I. Enukashvily
  • Patent number: 8652770
    Abstract: An improved method for storing platelets and compositions that contain stored platelets for use in transfusions. The method entails obtaining a platelet concentrate from blood obtained from an individual and holding the platelet concentrate at refrigerated temperatures under an atmosphere having a pressure of from 3.5 to 5 bars comprising more than 65% xenon and for at least one week. Also provided is a refrigerated composition that contains a platelet concentrate, wherein the platelet concentrate contains xenon, and wherein the platelet concentrate has been isolated from an individual for at least seven days.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: February 18, 2014
    Assignee: Rich Products Corporation
    Inventors: Ilya Y. Ilyin, Maria G. Tkachman, Maria E. Urusova, James S. Jones, William E. Grieshober, Semyon Kogan, Pavel Butylin, Rostislav Khorenyan
  • Publication number: 20130344596
    Abstract: Provided is a method for reducing apoptosis in nucleated cells. The method entails holding nucleated cells in a container and adding a gas containing xenon to the container so that the pressure inside the container reaches between 0.5 to 4.0 Atm above ambient pressure; holding the container at between 0.5 to 4.0 Atm above ambient pressure for a period of time during which the temperature in the container is between 22° C. and 37° C.; lowering the temperature in the container to between 0.1° C. and 10° C. while maintaining the pressure of 0.5 to 4.0 Atm above ambient pressure and holding the container for a period of time; and reducing the pressure in the container to ambient pressure and increasing the temperature to 22° C.-37° C. By performing these steps, the cells undergo less apoptosis than a reference.
    Type: Application
    Filed: February 3, 2012
    Publication date: December 26, 2013
    Applicant: Advanced Preservations Technologies, LLC
    Inventors: William E. Grieshober, JR., James S. Jones, Semyon Kogan, Ilya Ilyin, Natella I. Enukashvily, Yana A. Filkina, Alexander N. Shumeev, Stanislav Kolchanov
  • Patent number: 8527290
    Abstract: Flour may be treated to denature the proteins and modify starches. The invention includes methods and systems for determining whether to use treated flour or untreated flour. The invention also includes methods and systems for determining whether to treat flour or not.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: September 3, 2013
    Assignee: Rich Products Corporation
    Inventors: Praveen Upreti, Rohit Jalali, William E. Grieshober, Jr., John S. Roberts, Melissa D. Haller, Michael Fuchs, Ilya Y. Ilyin
  • Publication number: 20130157249
    Abstract: A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.
    Type: Application
    Filed: June 21, 2012
    Publication date: June 20, 2013
    Inventors: Ilya Ilyin, Semyon Kogan, William E. Grieshober, JR., Igor Kachko, Vladimir Vasiliev, Stanislav A. Kolchanov, Yuriy Punin, Mark Bakhrakh, Alexander N. Shumeev
  • Publication number: 20120298691
    Abstract: A dispensing device having a housing capable of receiving a pre-packaged charge of pre-whipped topping or icing. The housing has an inner wall with a slot formed therein for receiving a rack that is capable of rotational and translational motion within the slot. The rack has a set of gear teeth that engage with a catch on a plunger. The piston moves in the axial direction to force the pre-whipped topping or icing through the outlet in its packaging. The catch on the piston is locked in one direction and pivots in the opposite direction such that the rack engages with the piston when it moves in a first direction and the rack disengages with the piston when it is moved in a second direction opposite the first direction.
    Type: Application
    Filed: August 2, 2012
    Publication date: November 29, 2012
    Inventors: Rohit Jalali, Christopher Vincent Tirone, Theodore Watson Rich, Steven A. Franz, William E. Grieshober, JR., Joseph Victor Bisacca, Lisa Augustine, Kerry Marshal Chace, Timothy A. Falken, David E. Moomaw
  • Publication number: 20120301582
    Abstract: Flour may be treated to denature the proteins and modify starches. The invention includes methods and systems for determining whether to use treated flour or untreated flour. The invention also includes methods and systems for determining whether to treat flour or not.
    Type: Application
    Filed: August 6, 2012
    Publication date: November 29, 2012
    Inventors: Praveen Upreti, Rohit Jalali, William E. Grieshober, JR., John S. Roberts, Melissa D. Haller, Michael Fuchs, Ilya Y. Ilyin
  • Patent number: 8297481
    Abstract: A dispensing device having a housing capable of receiving a pre-packaged charge of pre-whipped topping or icing. The housing has an inner wall with a slot formed therein for receiving a rack that is capable of rotational and translational motion within the slot. The rack has a set of gear teeth that engage with a catch on a plunger. The piston moves in the axial direction to force the pre-whipped topping or icing through the outlet in its packaging. The catch on the piston is locked in one direction and pivots in the opposite direction such that the rack engages with the piston when it moves in a first direction and the rack disengages with the piston when it is moved in a second direction opposite the first direction.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: October 30, 2012
    Assignee: Rich Products Corporation
    Inventors: Rohit Jalali, Christopher Vincent Tirone, Theodore Watson Rich, Steven A. Franz, William E. Grieshober, Jr., Joseph Victor Bisacca, Lisa Augustine, Kerry Marshal Chace, Timothy A. Falken, David E. Moomaw
  • Patent number: 8260623
    Abstract: Flour may be treated to denature the proteins and modify starches. The invention includes methods and systems for determining whether to use treated flour or untreated flour. The invention also includes methods and systems for determining whether to treat flour or not.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: September 4, 2012
    Assignee: Rich Products Corporation
    Inventors: Praveen Upreti, Rohit Jalali, William E. Grieshober, Jr., John S. Roberts, Melissa D. Haller, Michael Fuchs, Ilya Y. Ilyin
  • Publication number: 20120196362
    Abstract: Provides are improved methods for storing platelets and compositions that contain stored platelets for use in transfusions. The method entails obtaining a platelet concentrate from blood obtained from an individual and holding the platelet concentrate in at refrigerated temperatures under an atmosphere having a pressure of from 3.5 to 5 bars comprising more than 65% xenon and for at least one week. Also provided is a refrigerated composition that contains a platelet concentrate, wherein the platelet concentrate contains xenon, and wherein the platelet concentrate has been isolated from an individual for at least seven days.
    Type: Application
    Filed: April 12, 2012
    Publication date: August 2, 2012
    Inventors: Ilya Y. Ilyin, Maria G. Tkachman, Maria E. Urusova, James S. Jones, William E. Grieshober, Semyon Kogan, Pavel Butylin, Rostislav Khorenyan
  • Patent number: 8158339
    Abstract: Provides are improved methods for storing platelets and compositions that contain stored platelets for use in transfusions. The method entails obtaining a platelet concentrate from blood obtained from an individual and holding the platelet concentrate in at refrigerated temperatures under an atmosphere having a pressure of from 3.5 to 5 bars comprising more than 65% xenon and for at least one week. Also provided is a refrigerated composition that contains a platelet concentrate, wherein the platelet concentrate contains xenon, and wherein the platelet concentrate has been isolated from an individual for at least seven days.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: April 17, 2012
    Assignee: Rich Products Corporation
    Inventors: Ilya Y. Ilyin, Maria G. Tkachman, Maria E. Urusova, James S. Jones, William E. Grieshober, Semyon Kogan, Pavel Butylin, Rostislav Khorenyan
  • Publication number: 20100031892
    Abstract: Provided is a method for storage of live crustaceans. The method is performed by causing the live crustacean to enter into an anesthetized state by exposing the crustacean to a combination of xenon and oxygen, cooling the anesthetized live crustacean to a temperature of 1° C. to 10° C. to cause the crustacean to enter into a state of anabiosis, and storing the live crustacean in the state of anabiosis under ambient pressure at 1° C. to 10° C. under from 90% to 100% humidity. Also provided is a container containing a plurality of live crustaceans that are in a state of anabiosis via performance of the method.
    Type: Application
    Filed: July 7, 2009
    Publication date: February 11, 2010
    Inventors: Ilya Y. Ilyin, Maria G. Tkachman, Maria E. Urusova, James S. Jones, William E. Grieshober, Semyon Kogan, Pavel Butylin, Rostislav Khorenyan, Yuri Punin, Alexander Shumeev
  • Publication number: 20100009334
    Abstract: Provides are improved methods for storing platelets and compositions that contain stored platelets for use in transfusions. The method entails obtaining a platelet concentrate from blood obtained from an individual and holding the platelet concentrate in at refrigerated temperatures under an atmosphere having a pressure of from 3.5 to 5 bars comprising more than 65% xenon and for at least one week. Also provided is a refrigerated composition that contains a platelet concentrate, wherein the platelet concentrate contains xenon, and wherein the platelet concentrate has been isolated from an individual for at least seven days.
    Type: Application
    Filed: July 7, 2009
    Publication date: January 14, 2010
    Inventors: Ilya Y. Ilyin, Maria G. Tkachman, Maria E. Urusova, James S. Jones, William E. Grieshober, Semyon Kogan, Pavel Butylin, Rostislav Khorenyan
  • Publication number: 20090276268
    Abstract: Flour may be treated to denature the proteins and modify starches. The invention includes methods and systems for determining whether to use treated flour or untreated flour. The invention also includes methods and systems for determining whether to treat flour or not.
    Type: Application
    Filed: May 4, 2009
    Publication date: November 5, 2009
    Inventors: Praveen Upreti, Rohit Jalali, William E. Grieshober, JR., John S. Roberts, Melissa D. Haller, Michael Fuchs, Ilya Y. Ilyin