Patents by Inventor William E. Holmes
William E. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884564Abstract: Claimed herein is a method of applying amorphous Co—SiOx to activate PMS and produce SO4·? due to the formation of Co(II)-Ov, pairs via the substitution of Si by Co. The inherent Co significantly change the electronic structure of O and Si atoms in the Co—SiOx via final state effects and increase the conductivity in terms of more effective electron transfers. The claimed method using Co—SiOx functions as a more effective oxidative catalyst for the faster degradation of pollutants. The simplicity of the synthetic procedures indicates that the conductive Co—SiOx could be used for the activation of PMS and other electrochemical applications on a wider scale.Type: GrantFiled: July 30, 2021Date of Patent: January 30, 2024Assignee: University of Louisiana at LafayetteInventors: Daniel Dianchen Gang, Qiyu Lian, Mark E. Zappi, William E. Holmes
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Publication number: 20230046975Abstract: Claimed herein is a method of applying amorphous Co—SiOx to activate PMS and produce SO4.? due to the formation of Co(II)-Ov, pairs via the substitution of Si by Co. The inherent Co significantly change the electronic structure of O and Si atoms in the Co—SiOx via final state effects and increase the conductivity in terms of more effective electron transfers. The claimed method using Co—SiOx functions as a more effective oxidative catalyst for the faster degradation of pollutants. The simplicity of the synthetic procedures indicates that the conductive Co—SiOx could be used for the activation of PMS and other electrochemical applications on a wider scale.Type: ApplicationFiled: July 30, 2021Publication date: February 16, 2023Inventors: Daniel Dianchen Gang, Qiyu Lian, Mark E. Zappi, William E. Holmes
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Patent number: 11547654Abstract: This invention is a novel method of manufacture for hand-sanitizing lotions that retains the added benefits of prolonged effectiveness while avoiding demulsification as well as the resulting product. The invention presents a novel, more simplified process comprising a lower cooking temperature and an optimized ingredient addition protocol, designed for product stability and ingredient integrity.Type: GrantFiled: August 28, 2018Date of Patent: January 10, 2023Assignee: University of Louisiana at LafayetteInventors: Emmanuel D. Revellame, William E. Holmes
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Publication number: 20190060213Abstract: This invention is a novel method of manufacture for hand-sanitizing lotions that retains the added benefits of prolonged effectiveness while avoiding demulsification as well as the resulting product. The invention presents a novel, more simplified process comprising a lower cooking temperature and an optimized ingredient addition protocol, designed for product stability and ingredient integrity.Type: ApplicationFiled: August 28, 2018Publication date: February 28, 2019Inventors: Emmanuel D. Revellame, William E. Holmes
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Patent number: 7923221Abstract: The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains or fragments thereof in a single cell. The invention also relates to the vectors used to produce the immunoglobulin or fragment, and to cells transformed with the vectors.Type: GrantFiled: April 13, 1995Date of Patent: April 12, 2011Assignees: Genentech, Inc, City of HopeInventors: Shmuel Cabilly, Herbert L. Heyneker, William E. Holmes, Arthur D. Riggs, Ronald B. Wetzel
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Patent number: 7601827Abstract: Novel 2 polypeptides with binding affinity for the p185HER2 receptor, designated heregulin 2-? and heregulin 2-?, have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-? has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-? useful in the production of heregulin 2-? by recombinant means. Further provided an amino acid sequence of heregulin 2-? and heregulin 2-?. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.Type: GrantFiled: September 12, 2005Date of Patent: October 13, 2009Assignee: Genentech, Inc.Inventors: Richard L. Vandlen, William E. Holmes
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Patent number: 6953842Abstract: Novel 2 polypeptides with binding affinity for the p185HER2 receptor, designated heregulin 2-? and heregulin 2-?, have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-? has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-? useful in the production of heregulin 2-? by recombinant means. Further provided an amino acid sequence of heregulin 2-? and heregulin 2-?. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.Type: GrantFiled: December 17, 2001Date of Patent: October 11, 2005Assignee: Genentech, Inc.Inventors: Richard L. Vandlen, William E. Holmes
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Publication number: 20030023035Abstract: Novel 2 polypeptides with binding affinity for the p185HER2 receptor, designated heregulin 2-&agr; and heregulin 2-&bgr;, have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-&agr; has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-&agr; useful in the production of heregulin 2-&agr; by recombinant means. Further provided an amino acid sequence of heregulin 2-&agr; and heregulin 2-&bgr;. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.Type: ApplicationFiled: December 17, 2001Publication date: January 30, 2003Applicant: Genentech, Inc.Inventors: Richard L. Vandlen, William E. Holmes
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Patent number: 6399746Abstract: Novel polypeptides with binding affinity for the p185HER2 receptor, designated heregulin 2-&agr; and heregulin 2-&bgr;, have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-&agr; has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-&agr; useful in the production of heregulin 2-&agr; by recombinant means. Further provided an amino acid sequence of heregulin 2-&agr; and heregulin 2-&bgr;. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.Type: GrantFiled: October 14, 1998Date of Patent: June 4, 2002Assignee: Genentech, Inc.Inventors: Richard L. Vandlen, William E. Holmes
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Patent number: 6331415Abstract: The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce both the heavy and light chains or fragments thereof in a single cell. The invention also relates to the vectors used to produce the immunoglobulin or fragment, and to cells transformed with the vectors.Type: GrantFiled: June 10, 1988Date of Patent: December 18, 2001Assignee: Genentech, Inc.Inventors: Shmuel Cabilly, Herbert L. Heyneker, William E. Holmes, Arthur D. Riggs, Ronald B. Wetzel
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Patent number: 5859206Abstract: Novel polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-.alpha. useful in the production of heregulin 2-.alpha. by recombinant means. Further provided an amino acid sequence of heregulin 2-.alpha. and heregulin 2-.beta.. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.Type: GrantFiled: April 11, 1995Date of Patent: January 12, 1999Assignee: Genentech, Inc.Inventors: Richard L. Vandlen, William E. Holmes
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Patent number: 5856457Abstract: The cDNA encoding a member of or a class of novel PF4A receptors has been identified in human tissue. Provided herein is nucleic acid sequence of a PF4A receptor (the IL-8 receptor) useful as a diagnostic and in the recombinant preparation of PF4A receptors. The PF4A receptor is used in the preparation and purification of antibodies capable of binding to the receptor, and in diagnostic assays.Type: GrantFiled: March 24, 1995Date of Patent: January 5, 1999Assignee: Genentech, Inc.Inventors: James Lee, William E. Holmes, William I. Wood
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Patent number: 5856110Abstract: Novel 2 polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-.alpha. useful in the production of heregulin 2-.alpha. by recombinant means. Further provided an amino acid sequence of heregulin 2-.alpha. and heregulin 2-.beta.. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.Type: GrantFiled: May 12, 1995Date of Patent: January 5, 1999Assignee: Genentech, Inc.Inventors: Richard L. Vandlen, William E. Holmes
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Patent number: 5840525Abstract: A novel polypeptide with binding affinity for the p185.sup.HER2 receptor, designated heregulin-.alpha., has been identified and purified from cultured human cells. DNA sequences encoding additional heregulin polypeptides, designated heregulin-.alpha., heregulin-.beta.1, heregulin-.beta.2, heregulin-.beta.2-like, and heregulin-.beta.3, have been isolated, sequenced and expressed. Provided herein are nucleic acid sequences encoding the amino acid sequences of heregulins useful in the production of heregulins by recombinant means. Further provided are the amino acid sequences of heregulins and purification methods therefor. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.Type: GrantFiled: May 31, 1995Date of Patent: November 24, 1998Assignee: Genentech, Inc.Inventors: Richard L. Vandlen, William E. Holmes
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Patent number: 5834229Abstract: Novel 2 polypeptides with binding affinity for the p185.sup.HER2 receptor, designated heregulin 2-.alpha. and heregulin 2-.beta., have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2-.alpha. has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2-.alpha. useful in the production of heregulin 2-.alpha. by recombinant means. Further provided an amino acid sequence of heregulin 2-.alpha. and heregulin 2-.beta.. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.Type: GrantFiled: October 25, 1994Date of Patent: November 10, 1998Assignee: Genentech, Inc.Inventors: Richard L. Vandlen, William E. Holmes
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Patent number: 5783415Abstract: The cDNA encoding a member of or a class of novel PF4A receptors has been identified in human tissue. Provided herein is nucleic acid sequence of a PF4A receptor (the IL-8 receptor) useful as a diagnostic and in the recombinant preparation of PF4A receptors. The PF4A receptor is used in the preparation and purification of antibodies capable of binding to the receptor, and in diagnostic assays.Type: GrantFiled: March 24, 1995Date of Patent: July 21, 1998Assignee: Genentech, Inc.Inventors: James Lee, William E. Holmes, William I. Wood
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Patent number: 5767063Abstract: The cDNA encoding a member of or a class of novel PF4A receptors has been identified in human tissue. Provided herein is nucleic acid sequence of a PF4A receptor (the IL-8 receptor) useful as a diagnostic and in the recombinant preparation of PF4A receptors. The PF4A receptor is used in the preparation and purification of antibodies capable of binding to the receptor, and in diagnostic assays.Type: GrantFiled: March 24, 1995Date of Patent: June 16, 1998Assignee: Genentech, Inc.Inventors: James Lee, William E. Holmes, William I. Wood
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Patent number: 5641869Abstract: A novel polypeptide with binding affinity for the p185.sup.HER2 receptor, designated heregulin-.alpha., has been identified and purified from cultured human cells. DNA sequences encoding additional heregulin polypeptides, designated heregulin-.alpha., heregulin-.beta.1, heregulin-.beta.2, heregulin-.beta.2-like, and heregulin-.beta.3, have been isolated, sequenced and expressed. Provided herein are nucleic acid sequences encoding the amino acid sequences of heregulins useful in the production of heregulins by recombinant means. Further provided are the amino acid sequences of heregulins and purification methods therefor. Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.Type: GrantFiled: May 31, 1995Date of Patent: June 24, 1997Assignee: Genentech, Inc.Inventors: Richard L. Vandlen, William E. Holmes
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Patent number: 5633141Abstract: The cDNA encoding a member of or a class of novel PF4A receptors has been identified in human tissue. Provided herein is nucleic acid sequence of a PF4A receptor (the IL-8 receptor) useful as a diagnostic and in the recombinant preparation of PF4A receptors. The PF4A receptor is used in the preparation and purification of antibodies capable of binding to the receptor, and in diagnostic assays.Type: GrantFiled: April 7, 1995Date of Patent: May 27, 1997Assignee: Genentech, Inc.Inventors: James Lee, William E. Holmes, William I. Wood
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Patent number: 5571702Abstract: The cDNA encoding a member of or a class of novel PF4A receptors has been identified in human tissue. Provided herein is nucleic acid sequence of a PF4A receptor (the IL-8 receptor) useful as a diagnostic and in the recombinant preparation of PF4A receptors. The PF4A receptor is used in the preparation and purification of antibodies capable of binding to the receptor, and in diagnostic assays.Type: GrantFiled: March 24, 1995Date of Patent: November 5, 1996Assignee: Genentech, Inc.Inventors: James Lee, William E. Holmes, William I. Wood