Patents by Inventor William E. Mitch

William E. Mitch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230077280
    Abstract: Embodiments of the disclosure encompass methods of treating insulin resistance in an individual in need thereof by administering one or more STAT3 inhibitors to the individual. In specific aspects, the methods allow for reversing insulin resistance in individuals. The STAT3 inhibitor may be one or more particular small molecules encompassed herein.
    Type: Application
    Filed: December 3, 2020
    Publication date: March 9, 2023
    Inventors: William E. Mitch, Liping Zhang, David J. Tweardy, Imran Alibhai, Sofia de Achaval
  • Publication number: 20020110838
    Abstract: The present disclosure provides evidence that actin degradation, in particular to produce a proteolytic fragment of about 14 kDa, is an important marker of muscle protein wasting. Muscle biopsy samples from a patient suffering from, susceptible to, or treated for a catabolic condition are tested for the production of an actin cross reacting protein of about 14 kDa, as estimated by SDS-PAGE. The presence of this actin fragment is diagnostic of muscle protein wasting (catabolism) in a muscle biopsy sample. Where a treatment for the catabolic disorder and/or muscle protein wasting is given, the failure to observe reductions in the amount of the actin degradative product is diagnostic of a treatment which is not effective to ameliorate or prevent the wasting. Animal models in which there is muscle protein wasting, e.g., streptozotocin-treated diabetic rates, can be used to identify inhibitors of wasting by reduction in actin fragments in muscle biopsy specimens of treated animals.
    Type: Application
    Filed: November 7, 2001
    Publication date: August 15, 2002
    Inventors: William E. Mitch, Jie Du