Abstract: Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). The disclosed polynucleotides, compositions, and methods may be utilized for treating diseases and disorders through RNAi. Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.

Abstract: A modified non-elastomeric thermoplastic composition includes a non-elastomeric thermoplastic modified by molybdenum disulfide, polytetrafluoroethylene and an elastomeric binder.

Abstract: A composition comprises fibrillated polytetrafluoroethylene, molybdenum disulfide and a thermoplastic elastomeric material. In the composition, fibrillatable polytetrafluoroethylene is preassociated with molybdenum disulfide and combined with a thermoplastic elastomeric copolymer in relative amounts from as low as about 2 parts per hundred rubber to as high as about 12 parts per hundred rubber, with the balance thermoplastic elastomeric copolymer and filler. The composition can further include an unpolymerized polytetrafluoroethylene binder residue of the fibrillated polytetrafluoroethylene.

Abstract: An asphalt composition comprises asphalt mixed with an asphalt modifier, which combines a thermoplastic elastomeric copolymer and an effective amount of a fibrillated polytetrafluoroethylene and molybdenum disulfide particles. The thermoplastic elastomeric copolymer preferably comprises two incompatible polymers forming a two-phase copolymer including a thermoplastic end block polymer and an elastomeric mid block polymer. Preferably, the thermoplastic end block polymer is a styrene polymer and the elastomeric mid block polymer is selected from a group consisting of polybutadiene, polyisoprene and poly(ethylene-butylene). The asphalt modifier is made by mixing together under high shear, as for example, in a twin screw extruder, particles of a thermoplastic elastomeric copolymer, fibrillatable polytetrafluoroethylene and molybdenum disulfide until the fibrillatable polytetrafluoroethylene is substantially fibrillated and combined with the thermoplastic elastomeric copolymer.

Abstract: A bitumen and asphalt modifier comprises thermoplastic elastomeric copolymer and an effective amount of a fibrillated polytetrafluoroethylene and molybdenum disulfide particles. The thermoplastic elastomeric copolymer comprises two incompatible polymers forming a two-phase copolymer including a thermoplastic end block polymer and an elastomeric mid block polymer. The asphalt modifier is made by mixing together under high shear particles of a thermoplastic elastomeric copolymer, fibrillatable polytetrafluoroethylene and molybdenum disulfide until the fibrillatable polytetrafluoroethylene is substantially fibrillated and combined with the thermoplastic elastomeric copolymer.

Abstract: An ink jet pen (10) having a primary ink reservoir (12) connected to a printhead (16) and to a chamber (18) containing a capillary volume element (20). The pressure within the capillary element (20) is greater normal sub-atmospheric pressure within the ink reservoir (12) but is less than atmospheric pressure. In operation within a normal ambient pressure and temperature range, ink from the reservoir (12) does not enter the capillary volume element (20). Outside of the normal range, the increased pressure within the reservoir (12) causes ink to be drawn into the capillary volume element (20). This enables the pressure of the reservoir (12) to remain substantially constant so that ink is not ejected from the orifice plate of the printhead (16). As the pressure or temperature falls again into the normal range, the ink is drawn back into the primary ink reservoir (12) from the capillary volume element (20).

Abstract: Compositions are disclosed containing an elastomer, particulate polytetrafluoroethytlene and an amount of molybdenum disulfide effective to permit their manufacture. The particulate polytetrafluoroethylene may include amounts from 25 percent by weight to 80 percent by weight, and/or include small amounts of fibrillated polytetrafluoroethylene. Also disclosed are additives for such compositions, and methods for preparing such compositions and additives using polytetrafluoroethylene and molybdenum disulfide, and improved compositions and products.

Abstract: A composition is disclosed containing particulate polytetrafluoroethylene in amounts from 15 percent by weight to 80 percent by weight incorporated in an elastomer with an amount of molybdenum disulfide effective to permit its manufacture and in some cases lend its properties, and methods for preparing such compositions and for using molybdenum disulfide, and fibrillated particulate polytetrafluoroethylene to improve compositions and products are also disclosed.