Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: A shoe bottom or side cleaning device which is either portable or installed in a floor of an entrance to a dwelling or building, and is either manually or automatically operated. The device includes a plurality of side-by-side, elongated and rotated brushes, a funnel beneath the brushes, a motor for driving the brushes and a squirrel cage fan for collecting dirt from the brushes via the funnel, and a chamber for accumulating the collected dirt. The chamber can be equipped with a dirt collection bag. A central building vacuum system can assist the device's fan. The elongated brushes can have either a solid core or a twisted" wire core.

Abstract: A submarine radar antenna mast extension, retraction and rotation mechanism comprises a ball drive screw attached to the mast with a ball drive nut threaded to the screw. A rotary tube surrounds the mast with the mast keyed for translation within the rotary tube and prevented from rotation with respect to the rotary tube. An outer tube surrounds the rotary tube and effects a static hull penetration seal with respect to the submarine. The rotary tube rotates within the outer tube, but is prevented from translation with respect thereto. A brake/indexing assembly geared to the rotary tube selectively releases the rotary tube for rotation or locks the rotary tube to an indexed position for extension and retraction. A single bi-directional hydraulic drive motor geared to the ball drive nut effects mast extension and retraction by applying the brake to prevent rotary tube rotation. The drive motor effects mast rotation by releasing the brake.