Abstract: Systems and methods for controlling a printing press operation for alignment of plural images as are superposed onto one another. Plural images are aligned to one another as part of a color printing operation utilizing plural printing stations where registration marks associated with the plural respective images can be aligned to one another based upon an open loop feedback of registration information. One or more data sources, such as cameras, capture the registration marks and digitize the data so that alignment or misalignment can be determined based upon tolerance limits. Systems and methods of the present invention provide for real-time monitoring of image alignment so that an operator can quickly and easily make adjustments to printing cylinders to correct image alignment.