Abstract: A method including percutaneously positioning a delivery device in a blood vessel; locally introducing a treatment agent from the delivery device into the blood vessel upstream of an infarcted area or distressed area; and following introducing the treatment agent, occluding the blood vessel for a dwell time sufficient to allow the treatment agent to flow into targeted capillaries in or adjacent to the infarcted area. A system comprising a delivery device suitable for percutaneous insertion into a blood vessel of a patient, the delivery device comprising an occluding portion and a delivery cannula having a lumen therethrough; a controller coupled to a proximal portion of the delivery device comprising instruction logic to perform a method including introducing a treatment agent into the delivery cannula; and occluding a blood vessel following a predetermined delay time after introducing the treatment agent.

Abstract: Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.

Abstract: Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.

Abstract: A method and apparatus are disclosed for determining injection depth and/or tissue type based on the heat dissipation characteristics of body tissue.

Abstract: This invention is generally related to therapeutic treatment of a coronary vessel wall, and more particularly, to systems and methods for improving uptake of therapeutic agents within the endothelium for enhanced delivery of therapeutic agents to a treatment site. A medical device is provided that is capable of reducing the pressure applied to a vessel wall and delivering a therapeutic agent into the vessel wall. Also, methods are described for using the device to facilitate delivery and uptake of a therapeutic agent into the vessel wall.

Abstract: A guide catheter and a needle catheter are disclosed. The guide catheter construction provides for maximum articulation of the deflectable tip and maximum torque response during rotation. The needle catheter may include a release mechanism that imparts a sudden force to the needle in order to facilitate tissue penetration.

Abstract: A tendon deflection system including a shaft, a plurality of tendons movably disposed within the shaft, and a force-balancing element coupled to the tendons. In a first section, the plurality of tendons are arranged around the shaft at equal angles to each other and at an equal distance from the center of the shaft. The tendons operating in concert with the force-balancing element minimize the moment expressed in the first section. The second section is deflectable and includes at least one tendon, extending from the plurality of tendons in the first section, which is arranged along one side of the shaft such that the bending moment expressed in the second section is greater than the first section.

Abstract: A tendon deflection system including a shaft, a plurality of tendons movably disposed within the shaft, and a force-balancing element coupled to the tendons. In a first section, the plurality of tendons are arranged around the shaft at equal angles to each other and at an equal distance from the center of the shaft. The tendons operating in concert with the force-balancing element minimize the moment expressed in the first section. The second section is deflectable and includes at least one tendon, extending from the plurality of tendons in the first section, which is arranged along one side of the shaft such that the bending moment expressed in the second section is greater than the first section.

Abstract: A guide catheter and a needle catheter are disclosed. The guide catheter construction provides for maximum articulation of the deflectable tip and maximum torque response during rotation. The needle catheter may include a release mechanism that imparts a sudden force to the needle in order to facilitate tissue penetration.

Abstract: Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.

Abstract: Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.

Abstract: A guide catheter and a needle catheter are disclosed. The guide catheter construction provides for maximum articulation of the deflectable tip and maximum torque response during rotation. The needle catheter may include a release mechanism that imparts a sudden force to the needle in order to facilitate tissue penetration.

Abstract: A tendon deflection system including a shaft, a plurality of tendons movably disposed within the shaft, and a force-balancing element coupled to the tendons. In a first section, the plurality of tendons are arranged around the shaft at equal angles to each other and at an equal distance from the center of the shaft. The tendons operating in concert with the force-balancing element minimize the moment expressed in the first section. The second section is deflectable and includes at least one tendon, extending from the plurality of tendons in the first section, which is arranged along one side of the shaft such that the bending moment expressed in the second section is greater than the first section.

Abstract: A flexible composite drive shaft used with a flexible vascular atherectomy catheter for connecting a proximal rotating drive member and a distal rotatable working member. The flexible composite drive shaft includes a core of specially selected highly elastic shape memory alloy surrounded by a flexible torsional reinforcing helical wound member and a covering of a smooth polymeric material penetrating the interstices between the wound member and the outer surface of the core. The material of the core, the relative winding direction of the reinforcing member and the direction of angular offset between the reinforcing member and the core are selected to optimize the consistency of the rotational characteristics of the drive shaft in use.