Abstract: A reciprocating piston pump may include a pump chamber, a piston seal, a monolithic partially fluorinated polymer piston with a fluid engaging end, a seating end, and a longitudinal outer piston surface extending between the fluid engaging end and the seating end. The reciprocating piston pump may further include a drive assembly coupled to the seating end of the monolithic partially fluorinated polymer piston. The drive assembly operates to reciprocate the monolithic partially fluorinated polymer piston within the pump chamber between full aspirate and full dispense positions. The piston seal forms an interface between the longitudinal outer piston surface of the piston and the pump chamber. The monolithic partially fluorinated polymer piston and the drive assembly are configured such that the piston seal interfaces with the longitudinal outer piston surface over a full stroke length of the drive assembly between the full aspirate and full dispense positions.

Abstract: An injectable substance delivery device comprising a pen device body, a cartridge, a plunger, a drive mechanism, and at least one of a lock-out mechanism and a rate-limiting mechanism. The lock-out mechanism is provided through a ratchet engagement between the body and the plunger to restrict plunger movement and to ensure that the required needle puncture depth is realized prior to injection by locking out the injection mechanism from advancing until a specified force is applied to the skin. A rate-limiting mechanism is also provided through a user compressed plunger drive spring to ensure that a specific rate of injection is realized during the injection of a medicament.

Abstract: An injectable substance delivery device comprising a pen device body, a cartridge, a plunger, a drive mechanism, and at least one of a lock-out mechanism and a rate-limiting mechanism. The lock-out mechanism is provided through a ratchet engagement between the body and the plunger to restrict plunger movement and to ensure that the required needle puncture depth is realized prior to injection by locking out the injection mechanism from advancing until a specified force is applied to the skin. A rate-limiting mechanism is also provided through a user compressed plunger drive spring to ensure that a specific rate of injection is realized during the injection of a medicament.