Patents by Inventor William Eckelman

William Eckelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Technetium-and rhenium-bis(heteroaryl) complexes, and methods of use thereof
    Publication number: 20060093552
    Abstract: One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluoresence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.
    Type: Application
    Filed: February 14, 2005
    Publication date: May 4, 2006
    Applicant: Molecular Insight Pharmaceuticals, Inc.
    Inventors: John Babich, William Eckelman, Kevin Maresca, John Valliant, Jon Zubieta
  • Process for preparing iodovinyl-estradiol
    Patent number: 4541957
    Abstract: 17.alpha.-[(E)-2-Iodovinyl]-estra-1,3,5(10)-triene-3,17.beta.-diol wherein the iodine atom is radioactive can be produced from (E)-[3-acyloxy-17.beta.-hydroxyestra-1,3,5(10)-triene-17.alpha.-yl]vinyl dihydroxyborane in an excellent yield by iodinating the same and hydrolyzing the resulting 3-acyloxy-17.alpha.-[(E)-2-iodovinyl]-estra-1,3,5(10)-triene-17.beta.-ol.
    Type: Grant
    Filed: September 7, 1983
    Date of Patent: September 17, 1985
    Assignee: The George Washington University
    Inventors: Iwao Nakatsuka, William Eckelman, Waclaw J. Rzeszotarski