Patents by Inventor William Edward Salomon

William Edward Salomon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for modulating a genome
    Patent number: 12157898
    Abstract: Methods and compositions for modulating a target genome are disclosed. This disclosure relates to novel compositions, systems and methods for altering a genome at one or more locations in a host cell, tissue or subject, in vivo or in vitro. In particular, the invention features compositions, systems and methods for inserting, altering, or deleting sequences of interest in a host genome.
    Type: Grant
    Filed: July 19, 2023
    Date of Patent: December 3, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, William Edward Salomon, Jacob Rosenblum Rubens, Robert James Citorik, Zi Jun Wang, Kyusik Kim, Randi Michelle Kotlar, Ananya Ray, Robert Charles Altshuler, Sandeep Kumar, Nathaniel Roquet, Barrett Ethan Steinberg
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240374759
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 7, 2022
    Publication date: November 14, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Robert James Citorik, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Sandeep Kumar, Ananya Ray, Nathaniel Roquet, Jacob Rosenblum Rubens, William Edward Salomon, Barrett Ethan Steinberg, Zi Jun Wang, Ersin Akinci
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240318170
    Abstract: Methods and compositions for modulating a target genome are disclosed. The composition may comprise a first RNA encoding a polypeptide comprising a retrotransposase reverse transcriptase domain and a retrotransposase endonuclease domain. The composition may also comprise a second RNA comprising a sequence that binds the polypeptide and a heterologous object sequence. The composition may insert the sequence of the heterologous object sequence into a target DNA.
    Type: Application
    Filed: April 1, 2024
    Publication date: September 26, 2024
    Inventors: Jacob Rosenblum Rubens, Geoffrey A. von Maltzahn, Robert James Citorik, Barrett Ethan Steinberg, Donghui Li, William Edward Salomon
  • Methods and compositions for modulating a genome
    Patent number: 12065669
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: August 20, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • INTEGRASE COMPOSITIONS AND METHODS
    Publication number: 20240263153
    Abstract: Methods and compositions for modulating a target genome are disclosed. For instance, the disclosure provides site-specific recombinases (e.g., serine recombinases, e.g., serine integrases) capable of directing insertion of an insert DNA, or portion thereof, into a desired site in a target genome.
    Type: Application
    Filed: May 25, 2022
    Publication date: August 8, 2024
    Inventors: Jacob Rosenblum Rubens, Robert James Citorik, Yanfang Fu, Cecilia Giovanna Silvia Cotta-Ramusino, Zi Jun Wang, William Edward Salomon
  • HBB-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240252682
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating sickle cell disease (SCD) are described.
    Type: Application
    Filed: February 28, 2024
    Publication date: August 1, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, William Edward Salomon, Robert James Citorik, William Querbes, Luciano Henrique Apponi, Zhan Wang, Yanfang Fu, Daniel Gene Abernathy, Michael Christopher Holmes
  • METHODS OF ENRICHING FOR CIRCULAR POLYRIBONUCLEOTIDES
    Publication number: 20240240219
    Abstract: The methods of the disclosure can be used to enrich a population of circular polyribonucleotides in a mixture of linear polyribonucleotides, circular polyribonucleotides, and linear polydeoxyribonucleotides.
    Type: Application
    Filed: May 18, 2022
    Publication date: July 18, 2024
    Inventors: Randi Michelle KOTLAR, William Edward SALOMON
  • Methods and compositions for modulating a genome
    Patent number: 12037602
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: July 16, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • Methods and compositions for modulating a genome
    Patent number: 12031129
    Abstract: Methods and compositions for modulating a target genome are disclosed. The composition may comprise a first RNA encoding a polypeptide comprising a retrotransposase reverse transcriptase domain and a retrotransposase endonuclease domain. The composition may also comprise a second RNA comprising a sequence that binds the polypeptide and a heterologous object sequence. The composition may insert the sequence of the heterologous object sequence into a target DNA.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: July 9, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Jacob Rosenblum Rubens, Geoffrey A. von Maltzahn, Robert James Citorik, Barrett Ethan Steinberg, Donghui Li, William Edward Salomon
  • LTR TRANSPOSON COMPOSITIONS AND METHODS
    Publication number: 20240200104
    Abstract: Methods and compositions for altering a genome at one or more locations in a host cell, tissue, or subject are disclosed.
    Type: Application
    Filed: March 18, 2022
    Publication date: June 20, 2024
    Inventors: Robert James Citorik, William Edward Salomon, Zi Jun Wang, Jacob Rosenblum Rubens, Benjamin Harris Weinberg
  • CFTR-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240093186
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.
    Type: Application
    Filed: September 20, 2023
    Publication date: March 21, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Aamir Mir, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, Robert James Citorik, William Edward Salomon, William Querbes, Luciano Henrique Apponi, Zhan Wang
  • SERPINA-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240084334
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.
    Type: Application
    Filed: September 18, 2023
    Publication date: March 14, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, William Edward Salomon, Robert James Citorik, William Querbes, Luciano Henrique Apponi, Zhan Wang
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240084333
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 14, 2024
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • PAH-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240082429
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.
    Type: Application
    Filed: October 26, 2023
    Publication date: March 14, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, William Edward Salomon, Robert James Citorik, William Querbes, Luciano Henrique Apponi, Zhan Wang
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240076698
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 7, 2024
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • TISSUE-SPECIFIC METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240042058
    Abstract: The invention provides, inter alia, systems and associated methods, for modifying DNA, such as the genome of a cell. The systems, in certain embodiments, encompass one or more tissue-specific expression-control sequences, such as promoters and microRNA binding sites in addition to a transposase (or a nucleic acid encoding the same) and a template nucleic acid comprising a sequence to be inserted into the genome of a cell, tissue, or subject.
    Type: Application
    Filed: February 25, 2022
    Publication date: February 8, 2024
    Inventors: Robert James Citorik, Jacob Rosenblum Rubens, William Edward Salomon, Zi Jun Wang
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240035049
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: July 19, 2023
    Publication date: February 1, 2024
    Inventors: Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, William Edward Salomon, Jacob Rosenblum Rubens, Robert James Citorik, Zi Jun Wang, Kyusik Kim, Randi Michelle Kotlar, Ananya Ray, Robert Charles Altshuler, Sandeep Kumar, Nathaniel Roquet, Barrett Ethan Steinberg
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240018551
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 2, 2022
    Publication date: January 18, 2024
    Inventors: Stephen CLEAVER, Barrett Ethan STEINBERG, Jacob Rosenblum RUBENS, Robert James CITORIK, William Edward SALOMON, Zi Jun WANG
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20230348939
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: November 22, 2022
    Publication date: November 2, 2023
    Inventors: Anne Helen BOTHMER, Cecilia Giovanna Silvia COTTA-RAMUSINO, William Edward SALOMON, Jacob Rosenblum RUBENS, Robert James CITORIK, Zi Jun WANG, Kyusik KIM, Randi Michelle KOTLAR, Ananya RAY, Robert Charles ALTSHULER, Sandeep KUMAR, Nathaniel ROQUET, Barrett Ethan STEINBERG
  • TEMPLATE GUIDE RNA MOLECULES
    Publication number: 20230332184
    Abstract: The disclosure is directed, in part, to improved systems and nucleic acids for modifying target DNA.
    Type: Application
    Filed: December 5, 2022
    Publication date: October 19, 2023
    Inventors: Jacob Rosenblum RUBENS, Robert James CITORIK, Anne Helen BOTHMER, Aamir MIR, John Frederick BRIONES, William Edward SALOMON