Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.

Abstract: Methods and systems are disclosed that enable the leveraging of financial instrument research at an individual financial instrument level but across multiple classifications of financial instruments to efficiently build an investment portfolio for an investor based on a desired portfolio objective through a plurality of graphical user interfaces (GUIs).

Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.

Abstract: A lighting system including a light-emitting diode cradle securing at least one light-emitting diode and a modular unit comprising an arcuate portion, the arcuate portion comprising at least one diffusive reflective surface adapted to receive and reflect light from the at least one light-emitting diode. The lighting system further includes a diffusive transmissive element adapted to receive light reflected by the diffusive reflective surface and provide diffused light to an area requiring illumination.

Abstract: The present disclosure is directed towards a clamping assembly for compressing a plurality of optical plates of a high pressure cavitation system. The clamping assembly may include a mounting frame and a housing coupled to the mounting frame. The clamping assembly may further include a holder distal the housing, the holder having the plurality of optical plates disposed therein. The clamping assembly further including a controllable clamping mechanism operably coupled to a top of the housing, the controllable clamping mechanism applying an axial force to the plurality of optical plate.

Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.

Abstract: The present disclosure is directed towards a clamping assembly for compressing a plurality of optical plates of a high pressure cavitation system. The clamping assembly may include a mounting frame and a housing coupled to the mounting frame. The clamping assembly may further include a holder distal the housing, the holder having the plurality of optical plates disposed therein. The clamping assembly further including a controllable clamping mechanism operably coupled to a top of the housing, the controllable clamping mechanism applying an axial force to the plurality of optical plate.

Abstract: A weapon ball-and-socket-based weapon mounting system for removably attaching a to the body of a user. A ball stock adapted to be attached to a weapon at one end and configured with a substantially ball-shaped ball element on the other end replaced the conventional weapon butt stock. The ball stock mates with a body-supported socket adapted to receive the ball element by clicking in to the socket. The user is able to articulate the weapon into a rest position as well as rotating it through a full range of elevation and sweeping orientations.

Abstract: A rooftop device and method for collection of heated air for recirculation and/or ventilation. The rooftop device supplements cooling of roof structures and supplements building heat systems. A roof cap including an air passage is connected to air outlets disposed within the roof structure of a building and to air passages formed by panels mounted over the surface of a building's roof. The roof cap is connected to a vent which either exhausts air to the atmosphere and/or recirculates air to a building air handling system. Air flow within the device is enhanced by a fan disposed within the device.

Abstract: Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid.

Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.

Abstract: A capacitor comprising a casing of first and second casing members, a feedthrough electrically insulated from the casing and extending there from, first and second anodes electrically connected to each other within the casing, a cathode, and an electrolyte. The casing comprises first and second casing members, the first casing member having a first face wall joined to a surrounding side wall, and the second member having a second face wall, wherein the first and second casing members are secured together.

Abstract: A variable compression ratio mechanism for an internal combustion engine that has an engine block and a crankshaft is disclosed. The variable compression ratio mechanism has a plurality of eccentric disks configured to support the crankshaft. Each of the plurality of eccentric disks has at least one cylindrical portion annularly surrounded by the engine block. The variable compression ratio mechanism also has at least one actuator configured to rotate the plurality of eccentric disks.

Abstract: Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid.

Abstract: A communication system includes a receiver for receiving a serial bit stream from at least one communication channel, and a decoder, in communication with the receiver, for decoding words from the received serial bit stream, the words being defined at least in part by word boundaries in the received serial bit stream. The decoder contemporaneously synchronizes detection of bits and detection of the word boundaries in the received serial bit stream. The decoder preferably decodes digitized video signal information in the serial bit stream according to a Transition Minimized Differential Signalling protocol. The receiver and decoder are preferably part of an integrated circuit chip.

Abstract: A steering column lock assembly and a method of operating the same, the steering column lock assembly including a steering column having a gear portion and a rotatable shaft; an actuator operably attached to the steering column, the actuator being free to translate with respect to the steering column; and a lever arm operably attached to the steering column; wherein translation of the actuator engages the lever arm with the gear portion to lock the steering column.

Abstract: Administration of an irreversible tyrosine kinase inhibitor such as CI-1033 in combination with one or more other antineoplastic agent(s), or ionizing radiation is synergistic for treating cancer.

Abstract: A capacitor having a cylindrical shape or configuration so that it is capable of being inserted directly into the vasculature of a patient is described. A typical diameter for the present capacitor is about 6 mm. A capacitor of this size would occupy about 9% of the total cross-sectional area of the inferior vena cava prior to the crossover to the heart, where the typical diameter of the vein is about 20 mm. The crossover section has a diameter of about 11 mm to about 12 mm.

Abstract: A cooling system for use in with a transmissive optical element of a high average power laser (HAP). The system includes at least one optically transmissive element (TOC) that is held by a differential pressure in thermal contact with a heat sink assembly. In one embodiment, the heat sink assembly includes an optically transparent heat conductor (THC) attached to at least one face of the TOC. A vacuum formed between adjacent faces of the TOC and THC urges the facing planar surfaces into thermal contact with one another. Waste heat generated in the TOC is conducted to the THC. The temperature gradient inside the TOC is maintained substantially parallel to the direction of a laser beam being directed through the THC so that a given phase front of the beam exposes TOC material to the same temperature. As a result, the TOC does not perturb the phase front of the laser beam.