Abstract: Policy-informed e-signature processing. An electronic signature system (ESS) is interfaced to a content management system (CMS) that stores instances of shared files and coordinates policy-informed interactions with the shared files. Upon detection of an occurrence of an e-signature request event, electronic signature processing is carried out in a manner that observes one or more governance policies that control handling of shared files. When responding to an e-signature request event, the CMS observes the governance policies by issuing an electronic query to a database of parameters, wherein the parameters define metes and bounds of the governance policies. Upon determination that at least some of the governance policies at least potentially apply to the e-signature processing, the ESS and/or the CMS modifies metadata pertaining to one or more workflow objects that are associated with a computer-implemented workflow. The workflow may terminate or be terminated based upon the one or more governance policies.