Patents by Inventor William F. Crowley
William F. Crowley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140094407Abstract: The invention relates to a therapeutic device for the delivery of therapeutic agents, e.g. a peptide such as leuprolide, via the vagina to a female mammal. In some embodiments, the invention also relates to methods for the treatment of obesity and eating disorders, diabetes, multiple sclerosis (MS), endometriosis, uterine fibroids, polycystic ovarian disease, various cancers such as breast cancer, acne, hirsutism, microbial or fungal or viral infections such as bacterial vaginosis or AIDS/HIV, and chronic diseases using a disclosed vaginal device.Type: ApplicationFiled: December 4, 2013Publication date: April 3, 2014Applicant: Combinent Biomedical Systems, Inc.Inventors: Eyal S. Ron, William F. Crowley, JR., Robert S. Langer, Surajit K. Biswas, Quentin Baca, Armen Tashjian
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Publication number: 20120202742Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: ApplicationFiled: January 14, 2011Publication date: August 9, 2012Applicants: Massachusetts Institute of Technology, The General Hospital Corporation D/B/A Massachusetts General HospitalInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, JR.
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Publication number: 20110280922Abstract: The invention relates to a therapeutic device for the delivery of therapeutic agents, e.g. a peptide such as leuprolide, via the vagina to a female mammal. In some embodiments, the invention also relates to methods for the treatment of obesity and eating disorders, diabetes, multiple sclerosis (MS), endometriosis, uterine fibroids, polycystic ovarian disease, various cancers such as breast cancer, acne, hirsutism, microbial or fungal or viral infections such as bacterial vaginosis or AIDS/HIV, and chronic diseases using a disclosed vaginal device.Type: ApplicationFiled: November 9, 2009Publication date: November 17, 2011Applicant: Combinent Biomedical Systems, Inc.Inventors: Eyal S. Ron, William F. Crowley, Robert Langer, Surajit K. Biswas, Quentin Baca, Armen Tashjian, Preston H. Saunders
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Patent number: 7883718Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: GrantFiled: May 22, 2008Date of Patent: February 8, 2011Assignee: The General Hospital CorporationInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, Jr.
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Patent number: 7838024Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: GrantFiled: May 22, 2008Date of Patent: November 23, 2010Assignees: The General Hospital Corporation, Massachusetts Institute of TechnologyInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, Jr.
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Patent number: 7833545Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: GrantFiled: April 29, 2004Date of Patent: November 16, 2010Assignee: The General Hospital CorporationInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, Jr.
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Patent number: 7829112Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: GrantFiled: May 22, 2008Date of Patent: November 9, 2010Assignee: The General Hospital CorporationInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, Jr.
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Publication number: 20090274654Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: ApplicationFiled: May 22, 2008Publication date: November 5, 2009Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, Massachusetts Institute of TechnologyInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, JR.
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Publication number: 20090060982Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: ApplicationFiled: May 22, 2008Publication date: March 5, 2009Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, Massachusetts Institute of TechnologyInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, JR.
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Publication number: 20080286339Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: ApplicationFiled: May 22, 2008Publication date: November 20, 2008Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, Massachusetts Institute of TechnologyInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, JR.
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Publication number: 20080286322Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: ApplicationFiled: May 22, 2008Publication date: November 20, 2008Applicants: the General Hospital Corporation d/b/a Massachusetts General Hospital, Massachusetts Institute of TechnologyInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley, JR.
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Publication number: 20080248017Abstract: The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.Type: ApplicationFiled: May 22, 2008Publication date: October 9, 2008Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Eyal S. Ron, Robert S. Langer, William F. Crowley
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Patent number: 5824637Abstract: A method for contraception which features administering to a patient a contraceptive agent having activin-antagonist activity. The contraceptive agent results in inhibition of the activin-stimulated release of FSH, thereby resulting in a decrease in fertility and facilitating contraception in the patient.Type: GrantFiled: February 28, 1997Date of Patent: October 20, 1998Assignee: The General Hospital CorporationInventors: William F. Crowley, J. Larry Jameson, Alan L. Schneyer, Jeffrey Weiss
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Patent number: 5658876Abstract: A method for contraception which features administering to a patient a contraceptive agent having activin-antagonist activity. The contraceptive agent results in inhibition of the activin-stimulated release of FSH, thereby resulting in a decrease in fertility and facilitating contraception in the patient.Type: GrantFiled: April 28, 1994Date of Patent: August 19, 1997Assignee: The General Hospital CorporationInventors: William F. Crowley, J. Larry Jameson, Alan L. Schneyer, Jeffrey Weiss
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Patent number: 5130137Abstract: This invention is directed to a delivery system and a method useful for the treatment of benign ovarian secretory disorders in female mammals by administering an LHRH composition. The method comprises administering during the entire follicular phase of the menstrual cycle, beginning at the time of menses, an LHRH composition and sufficient levels of an estrogenic steriod to counteract the possibility of side effects which may develop during prolonged therapy with LHRH. Following the follicular phase, at the beginning of the luteal phase, and for the entire course of the luteal phase, the LHRH/estrogenic steroid combination administered during the follicular phase, in combination with a physiological amount of progestational steroid, is administered.Type: GrantFiled: August 9, 1989Date of Patent: July 14, 1992Assignee: The General Hospital CorporationInventor: William F. Crowley, Jr.
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Patent number: 4762717Abstract: This invention is directed to a delivery system and a method useful for preventing pregnancy in female mammals by administering an LHRH composition. The method comprises administering during the entire follicular phase of the menstrual cycle, beginning at the time of menses, an LHRH composition and sufficient levels of an estrogenic steroid to counteract the possibility of side effects which may develop during prolonged therepy with LHRH. Following the follicular phase, at the beginning of the luteal phase, and for the entire course of the luteal phase, the LHRH/estrogenic steroid combination administered during the follicular phase, in combination with a physiological amount of progestational steroid, is administered.The delivery system comprises means for administering the LHRH composition, estrogenic steroid and progestational steroid.Type: GrantFiled: March 21, 1986Date of Patent: August 9, 1988Assignee: The General Hospital CorporationInventor: William F. Crowley, Jr.