Patents by Inventor William F. Dall'Acqua

William F. Dall'Acqua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals and structure of a human IgG Fc variant with enhanced FcRn binding
    Patent number: 8775090
    Abstract: Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: July 8, 2014
    Assignee: MedImmune, LLC
    Inventors: Vaheh Oganesyan, William F. Dall'Acqua, Herren Wu
  • CRYSTALS AND STRUCTURE OF A HUMAN IgG Fc VARIANT WITH ENHANCED FcRn BINDING
    Publication number: 20110288276
    Abstract: Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them.
    Type: Application
    Filed: December 10, 2009
    Publication date: November 24, 2011
    Inventors: Vaheh Oganesyan, William F. Dall'Acqua, Herren Wu