Patents by Inventor William F. Goeckeler

William F. Goeckeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic ligands and complexes
    Patent number: 5652361
    Abstract: A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.
    Type: Grant
    Filed: March 8, 1993
    Date of Patent: July 29, 1997
    Assignee: The Dow Chemical Company
    Inventors: Jaime Simon, Joseph R. Garlich, Garry E. Kiefer, Kenneth McMillan, Richard Keith Frank, William F. Goeckeler, William A. Fordyce, Roberta C. Cheng, William J. Kruper, Jr., Sharon Baughman, David A. Wilson
  • Organic amine phosphonic acid complexes for the treatment of calcific tumors
    Patent number: 5300279
    Abstract: Particle-emitting radionuclides, e.g. Gd-159, Ho-166, Lu-177 and Yb-175, have been complexed with organic aminoalkylenephosphonic acids. These complexes have been found useful in compositions for the therapeutic treatment of calcific tumors or the relief of bone pain in animals.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: April 5, 1994
    Assignee: The Dow Chemical Company
    Inventors: Jaime Simon, Joseph R. Garlich, William F. Goeckeler, Davis A. Wilson, Wynn A. Volkert, David E. Troutner
  • Radio labeled organic amine phosphonic acid complexes for the treatment of calcific tumors
    Patent number: 5066478
    Abstract: Particle-emitting radionuclides, e.g. Gd-159, Ho-166, Lu-177 and Yb-175, have been complexed with organic aminoalkylenephosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions for the therapeutic treatment of calcific tumors in animals and in relief of bone pain.
    Type: Grant
    Filed: January 30, 1990
    Date of Patent: November 19, 1991
    Assignee: The Dow Chemical Company
    Inventors: Jaime Simon, David A. Wilson, Wynn A. Volkert, David E. Troutner, William F. Goeckeler
  • Organis amine phosphonic acid complexes for the treatment of calcific tumors
    Patent number: 4898724
    Abstract: Particle-emitting radionuclides, e.g. Samarium-153, have been complexed with organic aminoalkylenephosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions for the therapeutic treatment of calcific tumors in animals.
    Type: Grant
    Filed: May 14, 1987
    Date of Patent: February 6, 1990
    Assignee: The Dow Chemical Company
    Inventors: Jaime Simon, David A. Wilson, Wynn A. Volkert, David E. Troutner, William F. Goeckeler
  • Radioactive compositions for the treatment of calcific tumors
    Patent number: 4897254
    Abstract: Certain particle-emitting radionuclides, e.g. Samarium-153, have been complexed with certain alkylenepolyaminocarboxylic acid chelants. Compositions containing these complexes have been found useful in the treatment of calcific tumors in animals. The stability constant, log K, of the useful complexes is from about 14 to about 17 and the molar ratio of chelant to radionuclide in the compositions is such that the chelant is present in an amount sufficient to inhibit uptake of the radionuclide by soft tissue.
    Type: Grant
    Filed: March 3, 1987
    Date of Patent: January 30, 1990
    Assignee: The Dow Chemical Company
    Inventors: Jaime Simon, Wynn A. Volkert, David A. Wilson, David E. Troutner, William F. Goeckeler
  • Bone marrow suppressing agents
    Patent number: 4853209
    Abstract: The invention concerns a method for suppressing bone marrow which comprises administering at least one bone marrow suppressing radionuclide composition selected from the group of radionuclide compositions comprised of at least one of Samarium-153, Gadolinium-519, and Holmium-166 and at least one of ethylenediaminetetramethylenephosphonic acid, diethylenetriaminepentamethylenephosphonic acid, hydroxyethylethylenediaminetrimethylenephosphonic acid, nitrilotrimethylenephosphonic acid and tris(2-aminoethyl)aminehexamethylenephosphonic acid, or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: October 27, 1987
    Date of Patent: August 1, 1989
    Assignee: The Dow Chemical Company
    Inventors: Donald A. Kaplan, William F. Goeckeler