Patents by Inventor William F. Hoffman

William F. Hoffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4450171
    Abstract: 6(R)-[2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H- pyran-2-ones are prepared by acylation of the corresponding 8'-hydroxy compounds. The products are strong inhibitors of the biosynthesis of cholesterol.
    Type: Grant
    Filed: June 14, 1982
    Date of Patent: May 22, 1984
    Assignee: Merck & Co., Inc.
    Inventors: William F. Hoffman, Robert L. Smith, Alvin K. Willard
  • Patent number: 4444784
    Abstract: 6(R)-[2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl]-4 (R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones are prepared by acylation of the corresponding 8'-hydroxy compounds. The products are strong inhibitors of the biosynthesis of cholesterol.
    Type: Grant
    Filed: December 18, 1980
    Date of Patent: April 24, 1984
    Assignee: Merck & Co., Inc.
    Inventors: William F. Hoffman, Robert L. Smith, Alvin K. Willard
  • Patent number: 4380160
    Abstract: Apparatus for deterring theft of trailers which utilize a tow ring having a central opening and upper and lower annular surfaces. The apparatus assumes the operational position when the upper surface of a base plate is positioned proximate to the lower surface of the tow ring and the lower surface of a top plate is positioned proximate to the upper surface of the tow ring. When assuming this operational position, a tongue integral with and upstanding from the base plate extends through the central opening of the tow ring and through an aperture formed in the top plate. The tongue has at least one hole located between its free end and the upper surface of the top plate to receive the shank of a padlock when the apparatus is in the operational position. A cover member is integral with the top member and overlies the free end of the tongue to protect the lock in its secured condition.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: April 19, 1983
    Inventor: William F. Hoffman
  • Patent number: 4375475
    Abstract: 6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    Type: Grant
    Filed: February 11, 1981
    Date of Patent: March 1, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Alvin K. Willard, Frederick C. Novello, William F. Hoffman, Edward J. Cragoe, Jr.
  • Patent number: 4322563
    Abstract: Substituted biphenyl-2-carboxaldehydes are prepared in good yield by reacting palladium complexes of substituted benzaldehyde aniline Schiff bases with substituted phenylmagnesium bromides in the presence of at least six, preferably eight, molar equivalents of triphenylphosphine.
    Type: Grant
    Filed: February 11, 1981
    Date of Patent: March 30, 1982
    Assignee: Merck & Co., Inc.
    Inventor: William F. Hoffman
  • Patent number: 4237144
    Abstract: This invention relates to 2,3-dihydro-2,6,7-trisubstituted-5-acylbenzofurans, derivatives thereof and processes for their preparation. The novel benzofurans described herein have diuretic-saluretic, uricosuric and antihypertensive pharmacological activity.
    Type: Grant
    Filed: June 21, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., William F. Hoffman
  • Patent number: 4237130
    Abstract: The invention relates to 2,3-dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids and derivatives thereof having diuretic-saluretic, uricosuric and antihypertensive pharmacological activity.
    Type: Grant
    Filed: June 21, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., William F. Hoffman
  • Patent number: 4189496
    Abstract: 2,3-Dihydro-6,7-disubstituted-5-thienylmethyl or furylmethyl benzofuran-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof are disclosed having diuretic-saluretic, uricosuric and antihypertensive activity.
    Type: Grant
    Filed: February 16, 1978
    Date of Patent: February 19, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., William F. Hoffman, Otto W. Woltersdorf, Jr.
  • Patent number: 4154742
    Abstract: 6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof and combinations of these compounds with antikaluretic agents are disclosed having diuretic-saluretic, uricosuric and antihypertensive activity.
    Type: Grant
    Filed: December 5, 1977
    Date of Patent: May 15, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr., William F. Hoffman
  • Patent number: 4085117
    Abstract: 6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids, the pharmaceutically acceptable salt, ester and amide derivatives thereof and combinations of these compounds with antikaluretic agents are disclosed having diuretic-saluretic, uricosuric and antihypertensive activity.
    Type: Grant
    Filed: October 18, 1976
    Date of Patent: April 18, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr., William F. Hoffman