Patents by Inventor William F. Huffman

William F. Huffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fab I inhibitors
    Patent number: 8153652
    Abstract: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: April 10, 2012
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter J. Burgess, Dalia R. Jakas, William F. Huffman, William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas
  • Fab I Inhibitors
    Publication number: 20110098277
    Abstract: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
    Type: Application
    Filed: April 12, 2010
    Publication date: April 28, 2011
    Inventors: Walter J. Burgess, Dalia Jakas, William F. Huffman, William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas
  • Fab I inhibitors
    Patent number: 7741339
    Abstract: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: June 22, 2010
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter J. Burgess, Dalia R. Jakas, William F. Huffman, William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas
  • Fab I Inhibitors
    Publication number: 20090221699
    Abstract: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
    Type: Application
    Filed: June 25, 2007
    Publication date: September 3, 2009
    Inventors: Walter J. Burgess, Dalia Jakas, William F. Huffman, William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas
  • Fab I inhibitors
    Patent number: 7250424
    Abstract: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: July 31, 2007
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter J. Burgess, Dalia R. Jakas, William F. Huffman, William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas
  • Fab I inhibitors
    Patent number: 7049310
    Abstract: Compounds are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: May 23, 2006
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Walter J. Burgess, Dalia Jakas, William F. Huffman, William H. Miller, Kenneth A. Newlander, Mark A. Seefeld, Irene N. Uzinskas
  • Calcilytic compounds
    Publication number: 20040014723
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: April 24, 2003
    Publication date: January 22, 2004
    Inventors: Pradip Bhatnagar, William M Bryan, James F Callahan, William F Huffman
  • Hemoregulatory peptides
    Patent number: 5620957
    Abstract: The invention provides compounds of the general formula: ##STR1## The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: April 15, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Pradip K. Bhatnagar, William F. Huffman, James E. Talmadge
  • 1,4 Diazocines as fibrinogen antagonists
    Patent number: 5539104
    Abstract: This invention relates to a method of inhibiting platelet aggregation using 1,4-diazocine compounds which are mimics of the peptide sequence Arg--Gly--Asp.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: July 23, 1996
    Assignee: SmithKline Beecham Corp.
    Inventors: James F. Callahan, William F. Huffman
  • .gamma.-turn peptidomimetics as fibrinogen antagonists
    Patent number: 5470849
    Abstract: This invention relates to a method of inhibiting platelet aggregation, and compounds which are mimics of the peptide sequence Arg-Gly-Asp.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: November 28, 1995
    Assignee: SmithKline Beecham Corp.
    Inventors: James F. Callahan, William F. Huffman
  • HIV protease inhibitors
    Patent number: 5438118
    Abstract: Peptide mimics, having a constrained peptide backbone conformation, are HIV protease inhibitors. A compound of this invention is, for example, 3-Benzyl-5(alaninyl-1-aminoethyl)-2,3,6,7-tetrahydro-N-azepinyl-2-propiony l-valinyl-valinyl methyl ester.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: August 1, 1995
    Assignee: SmithKline Beechman Corp.
    Inventors: James F. Callahan, William F. Huffman, Michael L. Moore, Kenneth A. Newlander
  • Intermediates for preparing 1,6-dicarba-vasopressin compounds
    Patent number: 4908475
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: March 13, 1990
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • 4'-Methyl-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid vasopressin antagonists
    Patent number: 4826813
    Abstract: Vasopressin antagonists which have a 4'-methyl-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid group have vasopressin antagonist activity without substantial agonist activity. A species of the invention is [1-(4'-methyl-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-8-arginine]vasopressin.
    Type: Grant
    Filed: May 21, 1987
    Date of Patent: May 2, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: William F. Huffman, Nelson C. F. Yim
  • Intermediates for preparing 1,6-dicarba-vasopressin compounds
    Patent number: 4810778
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: March 7, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • 1,6-dicarba-vasopressin compounds
    Patent number: 4760052
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: April 28, 1987
    Date of Patent: July 26, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • Vasopressin compounds
    Patent number: 4749782
    Abstract: Certain vasopressin-like compounds whose structures have a .beta.,.beta.-diethyl-.beta.-mercaptopropionic acid at position 1 have unexpectedly potent V.sub.2 -antagonist activity. A species of the group is [1-.beta.,.beta.-diethyl-.beta.-mercaptopropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-8-arginine-9-desglycine]vasopressin.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: June 7, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: William F. Huffman, Michael L. Moore, Nelson C. Yim
  • GLN- or ASN-vasopressin compounds
    Patent number: 4742154
    Abstract: Peptides whose structures resemble those of vasopressin antagonists but have both a carboxamido amino acid unit and a basic amino acid unit in the side chain have good antagonist activity. A species of the invention is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-8-glutamine-9-desglycine]-vasopressi n.
    Type: Grant
    Filed: October 23, 1985
    Date of Patent: May 3, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: William M. Bryan, William F. Huffman, Michael L. Moore
  • Des-proline-N-methylarginine vasopressins
    Patent number: 4687758
    Abstract: Peptides having vasopressin antagonist activity are prepared by a peptide synthesizer to insert a N-methylarginine at the 7-position of the structure. An example of this series of compounds is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-7-desproline-8-N-methylarginine-9-de sglycine]-vasopressin.
    Type: Grant
    Filed: November 19, 1985
    Date of Patent: August 18, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Fadia E. Ali, William F. Huffman, Garland R. Marshall, Michael L. Moore
  • Compositions and methods for producing vasodilation and antioxytocic activity
    Patent number: 4684622
    Abstract: Vasopressin derivatives having V.sub.1 and oxytocin antagonist activity whose structures are characterized by a Mpa unit at position 1 and a des-Pro unit at position 7 are prepared by standard peptide synthetic methods also using an oxidative cyclization of a dimercaptan. Representative species are [1-deaminopenicillamine-2-(O-methyl)-tyrosine-7-desproline-8-arginine-9-de sglycine]vasopressin or [1-.beta.-mercaptopropionic acid-2-D-(O-ethyl)tyrosine-3-isoleucine-4-threonine-7-desproline-8-arginin e-9-desglycine]-vasopressin.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: August 4, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Fadia E. Ali, William F. Huffman
  • Methods of producing vasodilation or antioxytocic activity
    Patent number: 4684621
    Abstract: Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V.sub.1 -vasopressin and oxytocin antagonist activity. A species of this series of new compounds is [1-desaminopenicillamine-2-(O-ethyl-D-tyrosine)-8-(1,4-diaminobutane)-9-de sglycinamide]-vasopressin.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: August 4, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Michael L. Moore, Nelson C. Yim