Patents by Inventor William F. Marzluff

William F. Marzluff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR CIRCULAR RNA MOLECULES
    Publication number: 20240141379
    Abstract: This invention is directed to AAV compositions for circular RNA expression and methods of expressing covalently closed, circular RNA.
    Type: Application
    Filed: June 14, 2023
    Publication date: May 2, 2024
    Inventors: Aravind Asokan, Erin Borchardt, Rita Meganck, William F. Marzluff
  • Methods and compositions for circular RNA molecules
    Patent number: 11718862
    Abstract: This invention is directed to AAV compositions for circular RNA expression and methods of expressing covalently closed, circular RNA.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: August 8, 2023
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Aravind Asokan, Erin Borchardt, Rita Meganck, William F. Marzluff
  • METHODS AND COMPOSITIONS FOR CIRCULAR RNA MOLECULES
    Publication number: 20230203508
    Abstract: This invention is directed to AAV compositions for circular RNA expression and methods of expressing covalently closed, circular RNA.
    Type: Application
    Filed: November 7, 2018
    Publication date: June 29, 2023
    Inventors: Aravind Asokan, Erin Borchardt, Rita Meganck, William F. Marzluff
  • METHODS AND COMPOSITIONS FOR CIRCULAR RNA MOLECULES
    Publication number: 20220090137
    Abstract: This invention is directed to AAV compositions for circular RNA expression and methods of expressing covalently closed, circular RNA.
    Type: Application
    Filed: October 20, 2021
    Publication date: March 24, 2022
    Inventors: Aravind Asokan, Erin Borchardt, Rita Meganck, William F. Marzluff
  • Stabilizing RNA by Incorporating Chain-Terminating Nucleosides at the 3'-Terminus
    Publication number: 20140342402
    Abstract: A method is disclosed for stabilizing histone stem-loop-containing mRNA by the addition of a chain-terminating nucleoside. The novel, synthetic mRNA contains a 3? histone stem-loop sequence. At the 3? end of the mRNA a chain-terminating nucleoside is incorporated, for example 3?-deoxyadenosine (cordycepin). The chain-terminating nucleoside blocks the addition of a 3?-terminal oligo(U) sequence to the mRNA containing the histone stem-loop. When the 3?-terminal oligo(U) sequence cannot be added, degradation of the mRNA is retarded. The mRNA then remains available to the translational machinery for a longer time, resulting in higher levels of protein synthesis.
    Type: Application
    Filed: January 3, 2013
    Publication date: November 20, 2014
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Robert E. Rhoads, Wei Su, William F. Marzluff
  • Stabilization of acrylamide solutions
    Patent number: 4233240
    Abstract: Acrylamide aqueous solutions when stored in closed containers without constant supply of oxygen as polymerization inhibitor will polymerize during storage. To extend the safe period of storage under these conditions, cupric ion at concentrations from 0.5 to about 10 parts per million parts acrylamide in the solution is used as a polymerization inhibitor.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: November 11, 1980
    Assignee: American Cyanamid Company
    Inventors: William F. Linke, William F. Marzluff
  • Catalyst preparation method
    Patent number: 4163735
    Abstract: Copper-magnesium silicate-carbonate catalysts of improved activity and catalyst life for use in continuous hydration of acrylonitrile to acrylamide are prepared by a novel method in which magnesium and copper are precipitated separately in a common mother liquor and the precipitate is separated and dried at 170.degree.-200.degree. C. before pelleting. Pellets made from the dried powder, when reduced and calcined for use in the hydration reaction have better combination of catalytic properties than prior art catalysts of the type.
    Type: Grant
    Filed: July 25, 1977
    Date of Patent: August 7, 1979
    Assignee: American Cyanamid Company
    Inventors: John A. Fetchin, William F. Marzluff