Abstract: A method of manufacture of pre-filled ampuls and hypodermic needles where an ampul is formed by injection-moulding and blow-moulding. The ampul is filled with medicaments at the blow-moulding stage and a hypodermic needle is then affixed to the ampul.

Abstract: A hypodermic syringe including a needle and a deformable ampul connected thereto adjacent a neck portion where a rupturable membrane extends across the neck portion sealing a medicament in the ampul.

Abstract: A staple-type fastener includes a separate receiving member that is wider than the diameter of the staple prongs. In use, the prongs are inserted through sheets of material to be fastened together and then into the receiving member, which may be fitted with a tab to facilitate removal. One embodiment of the fastener includes a wide upper cross-member to further reduce the tendency of the staple to tear through fastened sheet materials. In another embodiment of the fastener a foldable tab on the receiving member is adapted to have the staple prongs bent over it, the tab facilitating straightening of the prongs for removal of the fastener from the sheets of material.

Abstract: A hypodermic syringe including an ampul and a hypodermic needle in which the ampul has been made by the technique of plastic blow-molding and the syringe uses one of several embodiments of seals to maintain sterility of the medicament. One embodiment uses a cap assembly for the ampul. Another embodiment uses a cover assembly over the ampul and needle. Another embodiment uses a membrane in the interior of the neck of the ampul. Other embodiments include specially designed closures for the ampul of this invention.