Abstract: Methods systems and computer readable media are provided for extracting information pertaining to at least one moving target. A set of signal data are inputted to a principal components processor, wherein the set of signal data comprise signal data corresponding to at least one waveform acquired from the at least one moving target. A complex representation of the set of signal data is formed and, using a principal components processor, at least one complex principal component of the complex representation is calculated. At least one of the calculated complex principal components is automatically selected and each of the at least one automatically selected complex principal component is applied to extract information about the at least one moving target. Methods systems and computer readable media are provided extracting information pertaining to at least one moving target.

Abstract: Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mechanical property value resultant from the displacement of the material

Abstract: An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.

Abstract: One or more systems, methods, or computer program products can include receiving an echo data set including information representative of an echo sensed by a transducer, provided at least in part by one or more actual targets included in a region of interest. The region of interest can be modeled, including selecting or generating an array manifold matrix including information corresponding to any one or more candidate targets. The weights of the candidate targets can be determined using the array manifold matrix and the echo data set, including minimizing an argument of a function modeling the weights of the candidate targets. In an example, the echo data set can be dithered, such as by adding a specified dithering signal.

Abstract: In some illustrative embodiments, an incoming signal from a transducer in an ultrasound imaging beam-former apparatus is applied to an in-phase sample-and-hold and a quadrature sample-and-hold. The quadrature sample-and-hold may be clocked a quarter period behind the in-phase sample-and-hold. The output of the sample-and-holds are applied to in-phase and quadrature analog-to-digital converters. A magnitude calculator receives the in-phase and quadrature digital values, and outputs a magnitude. A phase calculator receives the in-phase and quadrature digital values, and outputs a phase. An apodizer applies a difference between an amplitude of the outgoing signal and the magnitude and applies a first illumination to a image point in substantial proportion to the difference, and a phase rotator applies a second illumination to the image point in substantial proportion to the phase.

Abstract: An improved device and method for collecting data used for ultrasonic imaging. The data is gathered over numerous transmit and echo receive cycles, or iterations and combined into a synthetic acquisition representing a complete echo characteristic acquisition. At each iteration, only a portion, or subset, of the echo characteristic is sampled and stored. During the iterations, the portion of the echo characteristic that is measured and sampled is varied by changing the relative sampling instants. That is, the time offset from the transmission to the respective sampling instant is varied. The sample sets representative of the entire echo characteristic are then compiled from the multiple subsets of the ultrasonic transmissions.

Abstract: An improved device and method for collecting data used for ultrasonic imaging. The data is gathered over numerous transmit and echo receive cycles, or iterations and combined into a synthetic acquisition representing a complete echo characteristic acquisition. At each iteration, only a portion, or subset, of the echo characteristic is sampled and stored. During the iterations, the portion of the echo characteristic that is measured and sampled is varied by changing the relative sampling instants. That is, the time offset from the transmission to the respective sampling instant is varied. The sample sets representative of the entire echo characteristic are then compiled from the multiple subsets of the ultrasonic transmissions.

Abstract: A system for displaying a plurality of hemostatic indexes is disclosed. The system includes a communication receiver configured to receive the hemostatic indexes and a graphical user interface (GUI) connected to the communication receiver and configured to simultaneously display the hemostatic indexes. The hemostatic indexes are derived from a plurality of independent measurements, such as the mechanical measurements determined using the sonorheometry systems and processes.

Abstract: Techniques (e.g., system, apparatus, method, machine-readable medium) can be configured for characterizing a rheological or other structural physical property of a sample of a substance. In an example, this can include acoustically bidirectionally deforming the portion of the sample over a deformation range about a neutral-deformation locus within the deformation range, measuring a deformation response of at least a portion of the sample to the insonification, and characterizing the physical property of the sample using the measured response of at least a portion of the sample to the insonification, even in the presence of a flowing substance.

Abstract: Methods, systems and computer program products for estimating changes in an object represented by first and second multidimensional datasets. The first dataset is a reference dataset and the second dataset is an altered dataset. Discrete data samples of the first dataset are processed to form a piecewise continuous representation thereof. An error function is computed for comparisons between discrete data samples in the second dataset and the piecewise continuous representation of the first dataset. An alteration of the second dataset relative to the first dataset that minimizes the error function is determined.

Abstract: Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue. Waves reflected off the tissue, or a flexible member that moves with the tissue, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. Repetition of the generating, receiving and estimating steps provides characterization of the at least one physical property over time. Methods, apparatus and systems for characterizing at least one physical property of blood, by generating a series of acoustic pulses and directing the series of pulses into the blood such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the blood.

Abstract: Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue. Waves reflected off the tissue, or a flexible member that moves with the tissue, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. Repetition of the generating, receiving and estimating steps provides characterization of the at least one physical property over time. Methods, apparatus and systems for characterizing at least one physical property of blood, by generating a series of acoustic pulses and directing the series of pulses into the blood such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the blood.

Abstract: A hand held ultrasonic instrument (10) is provided in a portable unit that performs C-Mode imaging and collects 3D image data. In a preferred embodiment a transducer array (60), display unit (20), beamformer (40), power system, and image processor are integrated in one enclosure weighing less than three pounds. In operation, the portable unit is scanned across a target and the displayed image is conveniently presented to the operator whereby the displayed image corresponds exactly to the target, or a scaled fashion if desired.

Abstract: An ultrasound transducer array having a transmit transducer element comprising a transmit transducer material interposed between a transmit electrode and a reference electrode, wherein voltages applied across the transmit electrode and reference electrode induce an acoustic wave to emanate from the transmit transducer material; and a plurality of receive transducer elements positioned in an array on the transmit transducer element, each of the plurality of the receive transducer elements comprising a receive electrode and a receive transducer material interposed between the receive electrode and the reference electrode, and wherein acoustic waves applied to the plurality of receive transducer elements induces receive voltage signals on the receive electrodes with respect to the reference electrode.

Abstract: A system and related method for obtaining volumetric cardiac data of a subject. The data is generated by forming a plurality of focused ultrasound images corresponding to a series of ranges, generating myocardial boundary data for each of the plurality of ultrasound images, calculating the area of the region defined by said myocardial boundary data for each of the plurality of ultrasound images, multiplying the area for each of the plurality of ultrasound images by a slice depth corresponding to said ultrasound image to obtain the slice volume of each slice, and summing the slice volumes to obtain a total volume. In an alternative embodiment the system and related method combine an automated volumetric ultrasound system for finding chamber volumes and myocardial thicknesses, with a diagnostic electrocardiogram system to enable simultaneous diagnosis of mechanical and electrical cardiac problems.

Abstract: Methods, systems and computer readable media for reconstruction of target locations and amplitudes from signals received from one or more real targets in a space are provided, wherein the signals are at least one of signals received from the near-field and broadband signals. The space is modeled as a region of interest, and an array manifold matrix is calculated from signals received from hypothetical targets in the region of interest. One or more signal vectors received from the one or more real targets are reshaped into a data vector. A hypothetical target configuration is identified that, when applied to a signal model comprising the array manifold matrix, matches the data vector, a reconstruction vector is calculated. The reconstruction vector is reshaped into a reconstructed representation of the real targets in the space, and at least one of outputting the reconstructed representation for viewing by a user, and storing the reconstructed representation for later use are performed.

Abstract: A hand held ultrasonic instrument (10) is provided in a portable unit that performs C-Mode imaging and collects 3D image data. In a preferred embodiment a transducer array (60), display unit (20), beamformer (40), power system, and image processor are integrated in one enclosure weighing less than three pounds. In operation, the portable unit is scanned across a target and the displayed image is conveniently presented to the operator whereby the displayed image corresponds exactly to the target, or a scaled fashion if desired.

Abstract: Pulse-echo imaging systems and methods are provided, including a transmit code sequencer and a pulse generation circuit, The transmit code sequencer is configured to input a transmit code sequence to the pulse generation circuit. A transducer is configured to receive electrical signals provided as pulses using coded excitation according to the transmit code sequence, and to transduce the electrical signals to pulses of energy other than electrical signals. The transducer is further configured to receive echoes of the pulses of energy other than electrical signals and convert the echoes to received electrical signals generate using coded excitation. A receive circuit is configured to receive the received electrical signals generate using coded excitation, perform analog sampling of the received electrical signals generate using coded excitation, and provide a weighted, summed digital signal by processing the analog samples.

Abstract: Methods systems and computer readable media are provided for extracting information pertaining to at least one moving target. A set of signal data are inputted to a principal components processor, wherein the set of signal data comprise signal data corresponding to at least one waveform acquired from the at least one moving target. A complex representation of the set of signal data is formed and, using a principal components processor, at least one complex principal component of the complex representation is calculated. At least one of the calculated complex principal components is automatically selected and each of the at least one automatically selected complex principal component is applied to extract information about the at least one moving target. Methods systems and computer readable media are provided extracting information pertaining to at least one moving target.

Abstract: Methods systems and system components for optimizing contrast resolution of an imaging or sensing system utilizing multiple channels of broadband data associated with an array of transducers. Channels or data are filtered by passing the channels of data through finite impulse response (FIR) filters on each channel. The filters each have multiple taps having tap weights pre-calculated as a function of distance of the array from an object that energy is being transmitted to or reflected from. The weights are pre-computed through a deterministic equation based on an a priori system model.