Patents by Inventor William Farinelli

William Farinelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190192424
    Abstract: A method for treating vascular diseases is provided. The method includes fabricating a sterile ice slurry including water and ice particles, cooling the sterile ice slurry to a predetermined temperature, and injecting the sterile ice slurry into a desired tissue region. The desired tissue region includes perivascular adipose tissue.
    Type: Application
    Filed: February 27, 2019
    Publication date: June 27, 2019
    Inventors: Lilit Garibyan, Jeffrey Shuhaiber, William A. Farinelli, Richard Rox Anderson
  • Publication number: 20190183558
    Abstract: Systems and methods for the use of cooling to trigger desirable effects of increased vasculature and/or development of new collagen in biological tissue are provided. In particular, the systems and methods provide a cooling treatment system configured to provide bulk or fractionated cooling at either at ablative temperatures or intermediary remodeling temperatures to promote tissue remodeling by inducing increased vasculature and/or the formation of new collagen.
    Type: Application
    Filed: August 29, 2017
    Publication date: June 20, 2019
    Inventors: Richard Rox Anderson, Lilit Garibyan, Emilia Javorsky, William Farinelli
  • Patent number: 10278724
    Abstract: Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: May 7, 2019
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Falguni Asrani, William Farinelli, Ajay Shah, Vincent Liu, Richard R. Anderson
  • Publication number: 20190053939
    Abstract: The present disclosure provides systems and method for medical ice slurry production. In particular, systems and methods are provided for medical ice slurry production that enable an end user to produce and deliver a sterile medical ice slurry at the point of care.
    Type: Application
    Filed: February 24, 2017
    Publication date: February 21, 2019
    Inventors: Lilit Garibyan, Richard Rox Anderson, William A. Farinelli, Emilia Javorsky
  • Publication number: 20190015155
    Abstract: The present disclosure is directed to systems and methods that facilitate delivery of a therapeutic agent into the skin of a subject. A first mechanism can create a first angled channel through a first location on a surface of a subject's skin at a first angle relative to the surface of the subject's skin. A second mechanism, associated with the first mechanism, can create a second angled channel through a second location on the surface of the subject's skin at a second angle relative to the surface of the subject's skin. The first angled channel and the second angled channel intersect to form a connected channel under the surface of the subject's skin.
    Type: Application
    Filed: January 9, 2017
    Publication date: January 17, 2019
    Inventors: William Farinelli, Richard Rox Anderson
  • Publication number: 20180353538
    Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.
    Type: Application
    Filed: January 3, 2018
    Publication date: December 13, 2018
    Applicant: The General Hospital Corporation
    Inventors: Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas, Gerard van Hamel Platerink
  • Publication number: 20180311079
    Abstract: The present disclosure is directed to systems and methods that removing exogenous particles from a target region of the skin of a patient. The systems and methods can employ dermal lavage to remove the exogenous particles from the target region. In some instances, the exogenous particles can be residual tattoo ink after a tattoo removal process. A conduit can be sized and dimensioned for insertion into or around the target region to inject an irrigation fluid that defines an irrigation area. The exogenous particles can be suspended in the irrigation fluid. A device can be configured to form one or more channels in the irrigation area so that the exogenous particles are removable from the irrigation area.
    Type: Application
    Filed: January 13, 2017
    Publication date: November 1, 2018
    Inventors: Lilit Garibyan, Richard Rox Anderson, William Farinelli, Fernanda H. Sakamoto, Martin Purschke
  • Publication number: 20180140863
    Abstract: Systems and methods are provided for treating or preventing carbon monoxide poisoning. In particular, systems and methods are provided for a phototherapy treatment or prevention system that delivers light radiation to a patient's body to photodissociate carbon monoxide from hemoglobin.
    Type: Application
    Filed: May 17, 2016
    Publication date: May 24, 2018
    Inventors: Warren M. Zapol, R. Rox Anderson, Luca Zazzeron, Walfre Franco, William A. Farinelli
  • Publication number: 20180140316
    Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.
    Type: Application
    Filed: January 16, 2018
    Publication date: May 24, 2018
    Inventors: Richard Rox ANDERSON, William A. FARINELLI, Walfre FRANCO, Joshua TAM, Fernanda H. SAKAMOTO, Apostolos G. DOUKAS, Martin PURSCHKE, Min YAO
  • Patent number: 9895162
    Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: February 20, 2018
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Richard Rox Anderson, William A. Farinelli, Walfre Franco, Joshua Tam, Fernanda H. Sakamoto, Apostolos G. Doukas, Martin Purschke, Min Yao
  • Publication number: 20180036029
    Abstract: Exemplary embodiments of apparatus and method for harvesting small portions of tissue (“micrografts”) to form grafts can be provided. For example, a hollow tube can be inserted into tissue at a donor site, where a distal end of the hollow tube can have two or more points or extensions to facilitate separation of the micrografts from the surrounding tissue. The exemplary apparatus can be provided that includes a plurality of such tubes for simultaneous harvesting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, or less than about 0.3 mm, which can promote healing of the donor site and/or viability of the harvested tissue. The micrografts can be approximately cylindrical or strip-shaped, and can be placed in a biocompatible matrix to form a graft or directly into tissue at the recipient site. Such exemplary micrografts can be obtained from skin or other types of tissue, e.g., various internal organs.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 8, 2018
    Inventors: Richard Rox ANDERSON, Michael R. HAMBLIN, Dieter MANSTEIN, William A. FARINELLI
  • Publication number: 20180028659
    Abstract: The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.
    Type: Application
    Filed: March 15, 2017
    Publication date: February 1, 2018
    Applicant: The General Hospital Corporation
    Inventors: Dilip Paithankar, Richard Dean Blomgren, Richard Rox Anderson, William A. Farinelli, Apostolos G. Doukas
  • Publication number: 20180021087
    Abstract: Exemplary embodiments of the present disclosure provide method and apparatus for facilitating stretching of a biological tissue by forming a plurality of micro-slits in the tissue. Each micro-slit can be less than about 2 mm or less than about 1.5 mm long, or even less than about 1 mm, such that small gaps that can heal quickly can be formed when the tissue is stretched. The micro-slits can be formed using a plurality of cutting arrangements or an ablative laser. The micro-slits can be formed in various patterns, including staggered rows, circular or spiral patterns, or random patterns.
    Type: Application
    Filed: August 15, 2017
    Publication date: January 25, 2018
    Inventors: Richard Rox Anderson, Andrea Willey, William A. Farinelli
  • Publication number: 20180008500
    Abstract: Exemplary methods and systems can be provided for resurfacing of skin that include formation of a plurality of small holes, e.g., having widths greater than about 0.2 mm and less than about 0.7 mm or 0.5 mm, using a mechanical apparatus. Compressive and/or tensile forces can then be applied to the treated region of skin as the damage heals to facilitate hole closure, and provide enhanced and/or directional shrinkage of the treated skin area.
    Type: Application
    Filed: August 16, 2017
    Publication date: January 11, 2018
    Inventors: Richard R. Anderson, Mathew Avram, Fernanda H. Sakamoto, Wikunda Limpiangkanan, William A. Farinelli
  • Patent number: 9827006
    Abstract: Exemplary embodiments of apparatus and method for harvesting small portions of tissue (“micrografts”) to form grafts can be provided. For example, a hollow tube can be inserted into tissue at a donor site, where a distal end of the hollow tube can have two or more points or extensions to facilitate separation of the micrografts from the surrounding tissue. The exemplary apparatus can be provided that includes a plurality of such tubes for simultaneous harvesting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, or less than about 0.3 mm, which can promote healing of the donor site and/or viability of the harvested tissue. The micrografts can be approximately cylindrical or strip-shaped, and can be placed in a biocompatible matrix to form a graft or directly into tissue at the recipient site. Such exemplary micrografts can be obtained from skin or other types of tissue, e.g., various internal organs.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: November 28, 2017
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Richard R. Anderson, Michael R. Hamblin, Dieter Manstein, William A. Farinelli
  • Publication number: 20170312314
    Abstract: One aspect of the invention provides a system of treating a sebaceous gland in human skin with light energy to reduce acne symptoms. The system includes: a composition comprising a metallic nanoparticle dispersed within a carrier; means to vibrate at least a portion of the skin surface to which the composition is applied; means to selectively remove at least some of the composition from the skin surface after application of the means to vibrate, while leaving the metallic nanoparticles in proximity to or within the sebaceous gland; and means to optically irradiate the skin to which the composition was applied with light energy after removal of at least some of the composition from the skin surface.
    Type: Application
    Filed: July 12, 2017
    Publication date: November 2, 2017
    Applicant: The General Hospital Corporation
    Inventors: Richard Rox Anderson, William A. Farinelli, Gerard van Hamel Platerink
  • Publication number: 20170274011
    Abstract: One aspect of the invention provides a slurry comprising: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible surfactant. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; a biocompatible surfactant; and a foam comprising a plurality of gas bubbles. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible excipient. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a lipolytic agent.
    Type: Application
    Filed: August 27, 2015
    Publication date: September 28, 2017
    Inventors: Lilit Garibyan, Richard Rox Anderson, William A. Farinelli, Emilia Javorsky
  • Publication number: 20170274078
    Abstract: Described herein are compositions comprising, and methods for using, biocompatible cold slurries and methods of administering the same to provide reversible inhibition of peripheral nerves in a subject in need thereof.
    Type: Application
    Filed: August 27, 2015
    Publication date: September 28, 2017
    Inventors: Lilit Garibyan, Richard Rox Anderson, William A. Farinelli, Emilia Javorsky
  • Patent number: 9730958
    Abstract: The present invention is directed to a method and apparatus for delivering substances, e.g., therapeutic substances, into openings on or near a skin surface, such as hair follicles, pores and/or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and/or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the therapeutic substance.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: August 15, 2017
    Assignee: The General Hospital Corporation
    Inventors: Richard Rox Anderson, William A. Farinelli, Gerard van Hamel Platerink
  • Patent number: 9687508
    Abstract: One aspect of the invention provides a method for alleviating acne including: applying a therapeutic substance to an area of skin having follicles, said therapeutic substance comprising a plurality of metal nanoparticles within a carrier; using a device to impart mechanical energy to deliver some of said therapeutic substance into a plurality of follicles; removing the composition remaining on the skin surface while leaving the therapeutic substance in said follicles; and irradiating the skin to which the composition was applied with light energy effective to treat acne.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: June 27, 2017
    Assignee: The General Hospital Corporation
    Inventors: Richard Rox Anderson, William A. Farinelli, Gerard van Hamel Platerink