Patents by Inventor William Farr
William Farr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180042873Abstract: Provided are uses of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the treatment or prophylaxis of transplant rejection and the protection of the heart during heart surgery. Provided is the use of selective aquaporin inhibitors, e.g., of aquaporin-4 (AQP4) or aquaporin-2 (AQP2) for the treatment or prophylaxis of transplant rejection and for the protection of the heart during heart surgery.Type: ApplicationFiled: November 13, 2015Publication date: February 15, 2018Applicant: Aeromics, Inc.Inventors: Marc F. PELLETIER, George William FARR, Paul Robert MCGUIRK
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Patent number: 9827253Abstract: Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel processes for their synthesis and novel intermediates for use in their synthesis. Also provided is use of a compound for the prophylaxis, treatment, and control of aquaporin-mediated conditions. Aquaporin inhibitors, e.g., inhibitors of AQP4 and/or AQP2, may be of utility in the treatment or control of diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord), hyponatremia, and excess fluid retention, as well as diseases such as epilepsy, retinal ischemia and other diseases of the eye, myocardial ischemia, myocardial ischemia/reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines.Type: GrantFiled: November 6, 2014Date of Patent: November 28, 2017Assignee: AEROMICS, INC.Inventors: Marc F. Pelletier, Paul Robert McGuirk, George William Farr, Robert Zamboni, John Colucci, Helmi Zaghdane
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Patent number: 9573885Abstract: The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and/or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g.Type: GrantFiled: June 27, 2015Date of Patent: February 21, 2017Assignee: AEROMICS, INC.Inventors: Marc F. Pelletier, George William Farr, Paul Robert McGuirk, Christopher H. Hall, Walter F. Boron
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Publication number: 20160346302Abstract: The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., glioblastoma and ovarian hyperstimulation syndrome. The invention provides, inter alia, methods of treating or controlling a disease condition mediated by an aquaporin, e.g., diseases or conditions of water imbalance and other diseases.Type: ApplicationFiled: November 6, 2014Publication date: December 1, 2016Applicant: Aeromics, Inc.Inventors: Marc F. PELLETIER, Paul Robert MCGUIRK, George William FARR, Steven WILLIAMS
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Publication number: 20160279155Abstract: Provided are novel formulations of 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate as described below and uses thereof. Also provided are kits comprising 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate. Also provided is a method of treating or controlling a disease or condition mediated by an aquaporin, e.g., diseases or conditions of water imbalance and other diseases.Type: ApplicationFiled: November 6, 2014Publication date: September 29, 2016Applicant: Aeromics, Inc.Inventors: Marc F. PELLETIER, Paul Robert MCGUIRK, George William FARR
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Publication number: 20160264604Abstract: Provided are novel prodrug salts of selective aquaporin inhibitors, their use as pharmaceuticals, and pharmaceutical compositions comprising them, and novel processes for their synthesis and novel intermediates for use in their synthesis. Also provided is use of a compound for the prophylaxis, treatment, and control of aquaporin-mediated conditions. Aquaporin inhibitors, e.g., inhibitors of AQP4 and/or AQP2, may be of utility in the treatment or control of diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord), hyponatremia, and excess fluid retention, as well as diseases such as epilepsy, retinal ischemia and other diseases of the eye, myocardial ischemia, myocardial ischemia/reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines.Type: ApplicationFiled: November 6, 2014Publication date: September 15, 2016Applicant: Aeromics, Inc.Inventors: Marc F. PELLETIER, Paul Robert MCGUIRK, George William FARR, Robert ZAMBONI, John COLUCCI, Helmi ZAGHDANE
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Publication number: 20150343159Abstract: There is provided an inhaler device comprising a housing, a mouthpiece, a seat for receiving a unit dose blister and a punch for piercing a lid of the unit dose blister. The housing comprises a base and a lid pivotally joined by a hinge, such that the lid is pivotable from a first ‘closed’ position in which it abuts the base to define a cavity, to a second ‘open’ position in which the cavity can be accessed. The seat and the punch are adapted to lie within the cavity when the lid is in the first ‘closed’ position and moving the lid from the ‘open’ position to the ‘closed’ position causes the punch to pierce a lid of a unit dose blister received in the seat. Only the lid of the unit dose blister is pierced.Type: ApplicationFiled: July 4, 2013Publication date: December 3, 2015Inventors: Philip William FARR, John DEAMER, Mark Gregory PALMER, Alan Anthony WILSON, Stephen Maurice Pitson
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Publication number: 20150342967Abstract: The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and/or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g.Type: ApplicationFiled: June 27, 2015Publication date: December 3, 2015Inventors: Marc F. PELLETIER, George William FARR, Paul Robert MCGUIRK, Christopher H. HALL, Walter F. BORON
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Publication number: 20150133405Abstract: The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases of water imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and/or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g.Type: ApplicationFiled: May 8, 2013Publication date: May 14, 2015Inventors: Marc F. Pelletier, George William Farr, Paul Robert Mcguirk, Christopher H. Hall, Walter F. Boron
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Patent number: 8590529Abstract: An actuator for an inhaler for delivering medicament by inhalation, comprising: a housing for receiving a canister which comprises a body which includes a base and a head and defines a chamber containing medicament, and a valve stem which extends from the body and from which medicament is in use delivered on actuation of the canister; an outlet through which a user in use inhales; and a nozzle assembly which provides for delivery of medicament through the outlet, wherein the nozzle assembly comprises a nozzle block which receives the valve stem of the canister and, as a separately-formed component, a nozzle outlet which is fluidly connected to the nozzle block and includes an outlet orifice from which medicament is in use delivered.Type: GrantFiled: August 21, 2007Date of Patent: November 26, 2013Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Gregor John McLennan Anderson, Penelope Ann Burgess, Gary Thomas Crosby, Tristan Fairbrother, Philip William Farr
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Publication number: 20130213394Abstract: A dust cap for a pMDI having a cap part adapted for a push-fit on the dispensing nozzle of the pMDI and a strap part for connecting the dust cap to the pMDI, wherein the cap part is slidably mounted on the strap part for sliding movement between an extended position and a contracted position.Type: ApplicationFiled: March 18, 2013Publication date: August 22, 2013Applicant: Glaxo Group LimitedInventors: Gregor John McLennan Anderson, Allen John Pearson, Peter John Brand, Mark Anthony Cox, Ian Cude, Philip William Farr, Andrew Michael Kelly, Daniel Thomas de Sausmarez Lintell, Paul Kenneth Rand
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Patent number: 8397714Abstract: An inhaler is provided with a restricting member to prevent unintentional actuation of the inhaler. Also provided is an inhaler with an extensible strap joining a dust cap to the housing of an inhaler, the strap being particularly suited for use with inhalers that comprise a restricting member. The inhaler is useful, for example, in the treatment of asthma.Type: GrantFiled: March 10, 2005Date of Patent: March 19, 2013Assignee: Glaxo Group LimitedInventors: Allen John Pearson, Gregor John McLennan Anderson, Peter John Brand, Mark Anthony Cox, Ian Cude, Phillp William Farr, Andrew Michael Kelly, Daniel Thomas De Sausmarez Lintell, Paul Kenneth Rand
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Patent number: 7914601Abstract: A method of cold starting a molten bath-based direct smelting process for producing molten iron in a vessel (3) is disclosed. The method includes a step of preheating the vessel before supplying solid feed materials into the vessel. The method also includes a subsequent step of supplying an oxygen-containing gas and solid feed materials including material for forming slag, iron-containing feed material, and carbonaceous material into the vessel and generating heat and forming a bath of molten material that includes molten iron and molten slag in the vessel. This step includes supplying feed materials to promote formation of molten slag over molten iron in an early stage of developing the molten bath.Type: GrantFiled: May 12, 2006Date of Patent: March 29, 2011Assignee: Technological Resources Pty. LimitedInventors: Iain William Farr, Rodney James Dry
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Publication number: 20100275909Abstract: An actuator for an inhaler for delivering drug by inhalation, comprising: a housing for receiving a canister which comprises a body which includes a base and a head and defines a chamber for containing drug, and a valve stem which extends from the body and from which drug is in use delivered on actuation of the canister; an outlet through which a user in use inhales; and a nozzle which provides for delivery of drug through the outlet; wherein at least a rear section of the outlet has an increasing internal dimension in a direction away from the nozzle.Type: ApplicationFiled: August 21, 2007Publication date: November 4, 2010Inventors: Gregor John McLennan Anderson, Penelope Ann Burgess, Gary Thomas Crosby, Tristan Fairbrother, Philip William Farr
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Patent number: 7827478Abstract: Systems and methods for generating dynamic form pages for accessing a database. An item model is stored in the database and defines attributes or characteristics of item types. The item model is separate from the actual data and from the data model. When a form page is requested, the page is dynamically generated by accessing the item model based on the requested form. The page is then displayed to the user. Data can be included in the page as necessary. Form pages can be generated on the fly and can automatically adapt to changes in the definition of the item model.Type: GrantFiled: September 8, 2005Date of Patent: November 2, 2010Inventors: William Farr, Scot Penrod
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Publication number: 20100224185Abstract: An actuator for an inhaler for delivering medicament by inhalation, comprising: a housing for receiving a canister which comprises a body which includes a base and a head and defines a chamber containing medicament, and a valve stem which extends from the body and from which medicament is in use delivered on actuation of the canister; an outlet through which a user in use inhales; and a nozzle assembly which provides for delivery of medicament through the outlet, wherein the nozzle assembly comprises a nozzle block which receives the valve stem of the canister and, as a separately-formed component, a nozzle outlet which is fluidly connected to the nozzle block and includes an outlet orifice from which medicament is in use delivered.Type: ApplicationFiled: August 21, 2007Publication date: September 9, 2010Inventors: Gregor John McLennan Anderson, Penelope Ann Burgess, Gary Thomas Crosby, Tristan Fairbrother, Philip William Farr
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Patent number: D644321Type: GrantFiled: February 8, 2011Date of Patent: August 30, 2011Assignee: Glaxo Group LimitedInventor: Philip William Farr
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Patent number: D662199Type: GrantFiled: August 15, 2008Date of Patent: June 19, 2012Assignee: Glaxo Group LimitedInventors: Gregor John McLennan Anderson, Gary Thomas Crosby, Philip William Farr, Joseph Paul Marino, Mark Digby Teucher, James Anthony West
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Patent number: D769438Type: GrantFiled: July 7, 2014Date of Patent: October 18, 2016Assignee: Glaxo Group LimitedInventors: Gary Thomas Crosby, John Deamer, Philip William Farr, Stephen Maurice Pitson, Alan Anthony Wilson
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Patent number: D814019Type: GrantFiled: September 13, 2016Date of Patent: March 27, 2018Assignee: Glaxo Group LimitedInventors: Gary Thomas Crosby, John Deamer, Philip William Farr, Stephen Maurice Pitson, Alan Anthony Wilson