Patents by Inventor William Floyd Fobare

William Floyd Fobare has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino-pyridines As Inhibitors Of Beta-secretase
    Publication number: 20100204245
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: April 20, 2010
    Publication date: August 12, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, William Floyd Fobare, William Ronald Solvibile, JR., Frank Eldridge Lovering, Jeffrey Scott Condon, Albert Jean Robichaud
  • Amino-5-(5-membered)heteroarylimidazolone Compounds And The Use Thereof For Beta-secretase Modulation
    Publication number: 20100168106
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: March 8, 2010
    Publication date: July 1, 2010
    Applicant: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Amino-pyridines as inhibitors of ?-secretase
    Patent number: 7732457
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: June 8, 2010
    Assignee: Wyeth LLC
    Inventors: Michael Sotirios Malamas, William Floyd Fobare, William Ronald Solvibile, Jr., Frank Eldridge Lovering, Jeffrey Scott Condon, Albert Jean Robichaud
  • Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for ?-secretase modulation
    Patent number: 7705030
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: April 27, 2010
    Assignee: Wyeth LLC
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Thienoisoquinoline-phenylsulfonamides and their use as ER-NF?B inhibitors
    Patent number: 7696221
    Abstract: This invention provides estrogen receptor modulators having the structure: wherein R1 to R7 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: April 13, 2010
    Assignee: Wyeth LLC
    Inventors: Richard Dale Coghlan, William Floyd Fobare, Eugene John Trybulski
  • AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE
    Publication number: 20090012139
    Abstract: The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: August 29, 2008
    Publication date: January 8, 2009
    Applicant: Wyeth
    Inventors: Michael Sotirios MALAMAS, James Joseph ERDEI, William Floyd FOBARE, Dominick Anthony QUAGLIATO, Schuyler Adam ANTANE, Albert Jean ROBICHAUD
  • AMINO-5-(5-MEMBERED)HETERO-ARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR beta-SECRETASE MODULATION
    Publication number: 20080306091
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: July 28, 2008
    Publication date: December 11, 2008
    Applicant: Wyeth
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators
    Patent number: 7459567
    Abstract: The present invention provides a substituted thienyl or furyl acylguanidine compound of formula I The present invention also provides methods for the inhibition of ?-secretase (BACE) and for the treatment of ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: December 2, 2008
    Assignee: Wyeth
    Inventors: William Floyd Fobare, William Ronald Solvibile, Jr.
  • Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of ?-secretase
    Patent number: 7423158
    Abstract: The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: September 9, 2008
    Assignee: Wyeth
    Inventors: Michael Sotirios Malamas, James Joseph Erdei, William Floyd Fobare, Dominick Anthony Quagliato, Schuyler Adam Antane, Albert Jean Robichaud
  • Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for ?-secretase modulation
    Patent number: 7417047
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: August 26, 2008
    Assignee: Wyeth
    Inventors: Michael Sotirios Malamas, Ping Zhou, William Floyd Fobare, William Ronald Solvibile, Iwan Suwandi Gunawan, James Joseph Erdei, Yinfa Yan, Patrick Michael Andrae, Dominick Anthony Quagliato
  • Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists
    Patent number: 6514991
    Abstract: This invention provides compounds of Formula I having the structure and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: February 4, 2003
    Assignee: Wyeth
    Inventors: Richard Dale Coghlan, William Floyd Fobare
  • Piperidino-phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
    Patent number: 6509358
    Abstract: This invention provides compounds of Formula I having the structure and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: January 21, 2003
    Assignee: Wyeth
    Inventors: William Floyd Fobare, Jill Freymuller
  • Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists
    Publication number: 20020068751
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 12, 2001
    Publication date: June 6, 2002
    Applicant: American Home Products Corporation
    Inventors: Richard Dale Coghlan, William Floyd Fobare
  • Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
    Patent number: 6395762
    Abstract: This invention provides compounds of Formula I having the structure wherein, R1, R2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: May 28, 2002
    Assignee: American Home Products Corporation
    Inventors: William Floyd Fobare, Jill Freymuller