Abstract: Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESR1) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.

Abstract: Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESRI) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.

Abstract: A synchronous belt drive system having: a synchronous belt with a tensile cord of high-modulus fiber such as glass, carbon, PBO, or aramid; a driver sprocket and at least one driven sprocket, at least one of which is an obround sprocket; and a tensioner having: a base having a cylindrical portion extending axially with a radially outer surface and a receiving portion, an eccentric arm pivotally engaged with the radially outer surface, a torsion spring disposed within the receiving portion, the torsion spring applying a biasing force to the eccentric arm, and a pulley journalled to the eccentric arm. Preferably, no one of the eccentric arm, pulley, or torsion spring is axially displaced along an axis A-A from the others. The obround sprocket has a toothed surface and at least one linear portion disposed between two arcuate portions having a constant radius, the linear portion having a predetermined length.

Abstract: The disclosure relates to a thermosiphon system operable to consistently maintain the permafrost and active frost layer in a frozen condition to adequately support buildings and other structures. During cooler seasons, the thermosiphon system uses a passive refrigeration cycle to efficiently maintain the frozen layers using the cold air. When the air temperature rises during the warmer months, the system transitions into an active refrigeration mode that uses a refrigeration system to minimize thawing or degradation of the permafrost and active frost layers.

Abstract: The invention relates to a method of treating a cartilage matrix-forming bone tumour and/or a metastatic cancer originating from a cartilage matrix-forming bone tumour, for example chondrosarcoma, in which one or more of an inhibitor of RUNX2 activity, an inhibitor of RUNX2 expression, an inhibitor of YBX1 activity and an inhibitor of YBX1 expression, is administered to a subject in need thereof. The invention also relates to an in vitro method for detecting the presence of a cartilage matrix-forming bone tumour in a subject or the risk of a subject developing a cartilage matrix-forming bone tumour, for example chondrosarcoma, in which the following steps are performed: (i) measuring the expression level of at least one of RUNX2 and YBX1 in a biological sample obtained from a subject, and (ii) comparing the expression level of RUNX2 and/or YBX1 in the biological sample obtained from the subject with the respective expression level of RUNX2 and/or YBX1 in normal cartilage or other biological material.

Abstract: A synchronous belt drive system comprising a first obround sprocket having a toothed surface and at least one linear portion disposed between two arcuate portions, the arcuate portions having a constant radius, the linear portion having a predetermined length, a sprocket having a toothed surface, the sprocket engaged to the first obround sprocket by an endless toothed member, and the first obround sprocket having a magnitude and a phase such that an angular displacement timing error between the sprocket and the first obround sprocket is less than 1.5 degree peak to peak.

Abstract: An adapter device and/or a thermostat device for use during installation and testing of in-floor heating systems. The adapter device allows for temporary electrical interconnection between a mat and an AC power source, and includes at least one switch configured to actuate based on a user-supplied force (e.g., a finger press) to temporarily electrically couple the mat to an AC power source. The at least one switch is further configured to automatically de-actuate in the absence of the user-supplied force to electrically decouple the mat from the AC power source. The thermostat device includes at least one integrated power measurement circuit for testing and diagnostics of an in-floor heating system.

Abstract: Provided herein are methods of determining tumoral sensitivity to hormonal (endocrine) therapy based upon an index of estrogen receptor (ER)- and progesterone receptor (PR)-related genes, referred to as the sensitivity to endocrine therapy index (SETER/PR index), and may have additional consideration for the proportion of ER gene (ESRI) RNA transcripts that contain a mutation relative to the value of the SETER/PR index. Further provided are methods of treating breast cancer patients determined to be sensitive to an endocrine therapy by the SETER/PR index.

Abstract: A synchronous belt drive system having: a synchronous belt with a tensile cord of high-modulus fiber such as glass, carbon, PBO, or aramid; a driver sprocket and at least one driven sprocket, at least one of which is an obround sprocket; and a tensioner having: a base having a cylindrical portion extending axially with a radially outer surface and a receiving portion, an eccentric arm pivotally engaged with the radially outer surface, a torsion spring disposed within the receiving portion, the torsion spring applying a biasing force to the eccentric arm, and a pulley journalled to the eccentric arm. Preferably, no one of the eccentric arm, pulley, or torsion spring is axially displaced along an axis A-A from the others. The obround sprocket has a toothed surface and at least one linear portion disposed between two arcuate portions having a constant radius, the linear portion having a predetermined length.

Abstract: The disclosure relates to a thermosiphon system operable to consistently maintain the permafrost and active frost layer in a frozen condition to adequately support buildings and other structures. During cooler seasons, the thermosiphon system uses a passive refrigeration cycle to efficiently maintain the frozen layers using the cold air. When the air temperature rises during the warmer months, the system transitions into an active refrigeration mode that uses a refrigeration system to minimize thawing or degradation of the permafrost and active frost layers.

Abstract: A synchronous belt drive system comprising a first obround sprocket having a toothed surface and at least one linear portion disposed between two arcuate portions, the arcuate portions having a constant radius, the linear portion having a predetermined length, a sprocket having a toothed surface, the sprocket engaged to the first obround sprocket by an endless toothed member, and the first obround sprocket having a magnitude and a phase such that an angular displacement timing error between the sprocket and the first obround sprocket is less than 1.5 degree peak to peak.

Abstract: A magnetic tracking tag for animals may detect the occurrence of a predation event. The tag may include a pH sensitive material that degrades in the environment of a predator's gut. The degradation of the pH sensitive material causes a change in a detectable magnetic field of the tag, which allows the tag to detect the predation event and adjust its operation accordingly.

Abstract: A timing error correction system comprising a three element linkage having at least one element pivotally mounted to a mounting surface, a timing belt engaged between a driver and a driven, a first element of the three element linkage in contact with a timing belt slack side, a second element of the three element linkage in contact with a timing belt tight side, and a spring imparting a load to the three element linkage.

Abstract: A magnetic tracking tag for animals may detect the occurrence of a predation event. The tag may include a pH sensitive material that degrades in the environment of a predator's gut. The degradation of the pH sensitive material causes a change in a detectable magnetic field of the tag, which allows the tag to detect the predation event and adjust its operation accordingly.

Abstract: This invention relates to a method for analyzing a liquid when inside a container in order to detect counterfeiting or adulteration of the liquid, the container being at least partially transparent to visible light.

Abstract: An applicator head for selectively dispensing product includes a base structure and a support structure. The base structure includes a top face inclined relative to a bottom face, and a first side wall. The top face includes a base flange, and defines a first orifice in fluid communication with a fastener of the bottom face. The support structure includes a lower face inclined relative to an upper face, and a second side wall. The upper face includes a top surface and defines a second orifice. The lower face includes a support flange engaged with the base flange such that the support structure is pivotable relative to the base structure between first and second positions. Fluid communication is facilitated from the fastener through the second orifice in only one of the first and second positions. A dispenser is also provided.

Abstract: A tracking tag for aquatic animals may detect the occurrence of a predation event. The tag may include a pH sensitive material that degrades in the environment of an animal's gut. The degradation of the pH sensitive material causes a change in a detectable characteristic of the tag, which allows the tag to detect the predation event and adjust its operation accordingly.

Abstract: This invention relates to a method for analysing a liquid when inside a container in order to detect counterfeiting or adulteration of the liquid, the container being at least partially transparent to visible light.

Abstract: A tracking tag for aquatic animals may detect the occurrence of a predation event. The tag may include a pH sensitive material that degrades in the environment of an animal's gut. The degradation of the pH sensitive material causes a change in a detectable characteristic of the tag, which allows the tag to detect the predation event and adjust its operation accordingly.

Abstract: A chronograph assembly for emitting an audible message at the top of each hour includes a clock structured to have a pair of hands indicating a time of day. The clock is coupled to a support surface. A processor is coupled to the clock. An electronic memory is coupled to the clock and the processor. The electronic memory stores a recorded audible message comprising the words “It's five o'clock somewhere”. A control is coupled to the clock and the electronic memory. The control selects an aural quality of the recorded audible message. A speaker is coupled to the clock and the processor. A sensor is coupled to the clock and the processor. The sensor detects a position of the hands on the clock. The processor is actuated when the hands are positioned in a trigger position. The speaker emits the recorded audible message when the processor is actuated.