Abstract: The present invention provides a composition for use in a method of treating osteosarcoma, Ewing sarcoma and/or a metastatic cancer originating from osteosarcoma or Ewing sarcoma. The present invention also provides a method of treating a cancer selected from the group consisting of osteosarcoma, Ewing sarcoma, a metastatic cancer originating from an osteosarcoma and a metastatic cancer originating from Ewing sarcoma.

Abstract: The disclosure relates to a thermosiphon system operable to consistently maintain the permafrost and active frost layer in a frozen condition to adequately support buildings and other structures. During cooler seasons, the thermosiphon system uses a passive refrigeration cycle to efficiently maintain the frozen layers using the cold air. When the air temperature rises during the warmer months, the system transitions into an active refrigeration mode that uses a refrigeration system to minimize thawing or degradation of the permafrost and active frost layers.

Abstract: The invention relates to a method of treating a cartilage matrix-forming bone tumour and/or a metastatic cancer originating from a cartilage matrix-forming bone tumour, for example chondrosarcoma, in which one or more of an inhibitor of RUNX2 activity, an inhibitor of RUNX2 expression, an inhibitor of YBX1 activity and an inhibitor of YBX1 expression, is administered to a subject in need thereof. The invention also relates to an in vitro method for detecting the presence of a cartilage matrix-forming bone tumour in a subject or the risk of a subject developing a cartilage matrix-forming bone tumour, for example chondrosarcoma, in which the following steps are performed: (i) measuring the expression level of at least one of RUNX2 and YBX1 in a biological sample obtained from a subject, and (ii) comparing the expression level of RUNX2 and/or YBX1 in the biological sample obtained from the subject with the respective expression level of RUNX2 and/or YBX1 in normal cartilage or other biological material.

Abstract: The disclosure relates to a thermosiphon system operable to consistently maintain the permafrost and active frost layer in a frozen condition to adequately support buildings and other structures. During cooler seasons, the thermosiphon system uses a passive refrigeration cycle to efficiently maintain the frozen layers using the cold air. When the air temperature rises during the warmer months, the system transitions into an active refrigeration mode that uses a refrigeration system to minimize thawing or degradation of the permafrost and active frost layers.

Abstract: An immunoassay utilizing the polymerase chain reaction to detect biological molecules in a sample. In one embodiment, the method employs a plurality of nucleic acid templates with varying annealing temperatures when annealed to a detectable probe.

Abstract: A meter is disclosed for measuring the dielectric constant of a particulate material, particularly grain, as a function of its moisture content. The meter includes a test cell for containing a sample of the particulate material to be tested. A single oscillator includes a variable frequency tuned circuit for varying the frequency of the single oscillator output. The tuned circuit includes a test cell capacitor using a sample of material to be tested as a dielectric, a calibrated variable standard capacitor and a variable trimming capacitor. An indicator is coupled to the calibrated variable standard capacitor to display a value representing the capacitance setting of the calibrated variable standard capacitor. A frequency monitor compares the output frequency of the oscillator with a selected frequency and a null display displays the difference between the output frequency of the oscillator and the selected frequency.

Abstract: A method to detect biological molecules in a sample which is an immuno polymerase chain reaction assay which comprises the detection of a complex which includes a ligand: nucleic acid conjugate bound to at least one biological molecule. The complex is detected by the addition of a second nucleic acid molecule which is adapted to anneal to the nucleic acid of the conjugate.

Abstract: We describe vectors for use is DNA vaccination which are adapted such that nucleic acids which encode antigenic polypeptides are presented to the imune system in a folder or partially folded state to facilitate the production of antibodies to the native protein.

Abstract: An apparatus for the activation of a remote device having a transmitter to generate and transmit user-set special coded signals. The transmitter has a function selector switch to select modes of operation for the transmitter. Included is also a receiver to receive the user-set special coded signals, and the receiver also has a function selector switch to select modes of operation for the receiver. The function selector switch selects the following modes of operation for the transmitter: (a) a “transmit/fire” mode that enables a fire signal to be transmitted to the receiver; (b) a “wake-up” mode that enables a set-up receiver mode for immediate firing; (c) a program mode for low power transmission of programmed codes; and (d) a “test” and operational mode that enables an operational test of the apparatus with no firing output.