Abstract: Compositions and methods for reducing MHC class II protein expression in a cell comprising genetically modifying CIITA for use e.g., in adoptive cell transfer therapies.

Abstract: Methods, systems, and media for navigating through content are provided. In some embodiments, the method comprises: receiving a first plurality of interactive stream items; causing the first plurality of interactive stream items to be presented in a first presentation mode; receiving a first user selection of an interactive stream item from at least a portion of the first plurality of interactive stream items; continuing to receive the stream of content including a second plurality of interactive stream items; determining a second presentation mode based at least in part on a content type associated with the second plurality of interactive stream items; causing the second plurality of interactive stream items to be presented in a second presentation mode; receiving a second user selection indicating that the interactive stream item is no longer selected; and causing the second plurality of interactive stream items to be presented in the first presentation mode.

Abstract: Embodiments provide systems, methods, and computer storage media for text style suggestions and/or text emphasis suggestions. In an example embodiment, an electronic design application provides a text style suggestion tool that generates text style suggestions to stylize a selected text element based on the context of the design. A text emphasis tool allows a user to select a text element and generate text emphasis suggestions for which words should be emphasized with a different text styling. Various interaction elements allow the user to iterate through the suggestions. For example, a set of style suggestions may be mapped to successive rotational increments around a style wheel, and as the user rotates through the positions on the style wheel, a corresponding text style suggestion is previewed and/or applied.

Abstract: An optical assembly (100) for use in a wearable device is provided, the assembly (100) comprising: a prism (104), a photonic integrated chip, PIC (108), a substrate layer (106), and a lid (102); wherein the PIC (108) is mounted onto the substrate layer (106); the prism (104) comprising: (i) a first input/output surface (112) optically coupled to the PIC (108), and (ii) a second input/output surface (114) optically coupled to the lid (102), the second input/output surface (114) orientated perpendicularly to the first input/output surface (112), and wherein the prism (104) provides an optical path and reflects a percentage of light from the first input/output surface (112) to the second input/output surface (114). Methods of manufacturing such an optical assembly are also provided.

Abstract: Described and disclosed herein are various embodiments of methods and systems configured to rapidly measure, analyze and provide in, for example, an on-site and out-patient setting within a short period of time, one or more physical parameters associated with a one or more of a patient's carotid arteries. Some embodiments comprise at least one computing device, at least one portable handheld ultrasound device or probe operably connected to the at least one computing device, the portable handheld ultrasound device being configured to provide to the computing device as outputs therefrom a series of ultrasound image frames acquired from the one or more of the patient's carotid arteries, and a display or monitor operably connected to the at least one computing device and configured to visually display to a user results generated by the at least one computing device.

Abstract: A system for placing real-time interactive images on, inside, or in the general vicinity of a moving vehicle, during a live feed, wherein a user has the capability to pause and then click on the provided HTML hyperlinks with the goal of a user learning more about an image and related products. The Images are read by Facial Recognition Software comparing a limited database of images.

Abstract: A centering assembly for an eddy current probe includes a foot element having a plurality of resilient cantilevered legs projecting radially about a central aperture and an adjustment element moveable relative to the foot element for exerting a radial force on the plurality of resilient cantilevered legs. Movement of the adjustment element allows an outside diameter of the plurality of resilient cantilevered legs to be maintained consistent as the plurality of resilient cantilevered legs are worn down during use.

Abstract: A cryptographic key management service receives a request, associated with a principal, to use a cryptographic key to perform a cryptographic operation. In response to the request, the service determines whether a rate limit specific to the principal is associated with the cryptographic key. If the rate limit is associated with the cryptographic key, the service generates a response to the request that conforms to the rate limit. The service provides the response in response to the request.

Abstract: Compositions and methods for reducing MHC class II protein expression in a cell comprising genetically modifying CIITA for use e.g., in adoptive cell transfer therapies.

Abstract: Methods, systems, and media for navigating through content are provided. In some embodiments, the method comprises: receiving a first plurality of interactive stream items; causing the first plurality of interactive stream items to be presented in a first presentation mode; receiving a first user selection of an interactive stream item from at least a portion of the first plurality of interactive stream items; continuing to receive the stream of content including a second plurality of interactive stream items; determining a second presentation mode based at least in part on a content type associated with the second plurality of interactive stream items; causing the second plurality of interactive stream items to be presented in a second presentation mode; receiving a second user selection indicating that the interactive stream item is no longer selected; and causing the second plurality of interactive stream items to be presented in the first presentation mode.

Abstract: Polynucleotides, polypeptides, compositions, and methods for genome editing using deamination are provided. An mRNA containing an open reading frame (ORF) encoding a polypeptide is provided herein. The polypeptide includes a cytidine deaminase and an RNA-guided nickase, and does not include a uracil glycosylase inhibitor (UGI). A composition provided herein may include two different mRNAs. The first mRNA includes an ORF encoding a cytidine deaminase and an RNA-guided nickase, and the second mRNA includes an ORF encoding uracil glycosylase inhibitor (UGI).

Abstract: A method and system for typing major histocompatibility complex (MHC) alleles. The method includes receiving a set of exon-resolution identifiers for an allele pair associated with an MHC gene. An exon-resolution identifier of the set of exon-resolution identifiers for a corresponding allele of the allele pair describes an allele group, a specific allele protein, and exon region information for the corresponding allele. A plurality of reads is received for a sample. For each exon-resolution identifier of the set of exon-resolution identifiers, a set of intron-resolution identifiers is identified to form a plurality of intron-resolution candidate identifiers. An intron-resolution identifier of the set of intron-resolution identifiers for the corresponding allele describes the allele group, the specific allele protein, the exon region information, and intron region information for the corresponding allele.

Abstract: A fuel cell system has a fuel cell stack including a plurality of fuel cells and an anode injector system, and a controller programmed. The controller, responsive to an amplitude of cyclic changes in voltage of at least some of the fuel cells exceeding a threshold, a frequency of the cyclic changes being within a predetermined range of a frequency associated with the anode injector system, and the voltage being less than a predetermined value, disables the fuel cell stack.

Abstract: A DC-DC power converter selectively electrically connected between a fuel cell stack and battery of a vehicle includes an input capacitor, an output capacitor, and an inductor electrically connected between the input and output capacitors. A flyback converter is isolated from the DC-DC power converter. One or more controllers operate the flyback converter to drive a voltage value of the input capacitor toward a voltage value of the fuel cell stack.

Abstract: A processing device provides, on a mobile device, a storyline content user interface (UI) for adding video content to a storyline, the storyline content UI having a first area allowing video playback, a second area including visual representations of video clips of one or more storylines, and a third area including a first UI element to record video content. In response to a user activation of the first UI element, the processing device causes recording of a new video clip to be initiated, determines that a duration of the new video clip satisfies a predetermined threshold, creates a visual representation of the new video clip, associates the new video clip with an additional storyline, and adds the visual representation of the new video clip to the second area. In response to a user selection of the visual representation of the new video clip in the second area of the storyline content UI, the processing device causes the new video clip to be associated with the storyline.

Abstract: A light emitting structure includes a pixel layer having at least one subpixel, a microlens layer having at least one microlens, the at least one microlens aligned with the at least one subpixel for providing a narrowly-confined on-axis emission profile along an on-axis direction, a first filler material layer and a second filler material layer between the pixel layer and the microlens layer, an interface between the first filler material layer and the second filler material layer configured for reflecting a portion of off-axis emissions from the at least one subpixel by total internal reflection (TIR).

Abstract: A request to add tags (e.g., labels, key-value pairs, or metadata) to resources can be digitally signed by the entity making the request, such that the source can be verified and an authorization determination made for each tag. For a request involving multiple services (or entities) that can each add tags, any tag added by a service can be included in the request and digitally signed by that service. Each service processing the request can also digitally sign the request before forwarding, so that each service signs a version of the request, which includes elements signed by other services earlier in the request chain. When the request is received to a tagging service, the service ensures that every tag was digitally signed by the appropriate authorized entity or service, and validates the signatures to ensure that no data was modified or omitted, before adding the tags to the designated resource(s).

Abstract: A vehicle includes a fuel cell, an inlet valve, a purge valve, and a controller. The fuel cell has an anode side configured to receive hydrogen. The inlet valve is configured to open to deliver the hydrogen to the anode side. The purge valve is configured to open to purge water and nitrogen from the anode side. The controller is programmed to, operate the inlet valve to inject hydrogen into the anode side via opening the inlet valve followed by closing the inlet valve. The controller is further programmed to, in response to a concentration of the hydrogen in the anode side being less than threshold, open the purge valve to purge water and nitrogen from the anode side.

Abstract: The disclosure relates to a vehicle with a traction battery and a fuel cell system, and a controller programmed to purge the fuel cell system by flowing air through it to remove moisture from the fuel cell system. The controller is configured to initiate the purge based on a distance of the vehicle from a destination, a state of charge of the traction battery, and ambient temperature conditions at the destination. The freeze preparation process can be initiated when the vehicle is approaching its destination and can be predicted using connectivity and communication with off-board sources.

Abstract: A fuel cell system has a fuel cell stack including a plurality of fuel cells and an anode injector system, and a controller programmed. The controller, responsive to an amplitude of cyclic changes in voltage of at least some of the fuel cells exceeding a threshold, a frequency of the cyclic changes being within a predetermined range of a frequency associated with the anode injector system, and the voltage being less than a predetermined value, disables the fuel cell stack.