Patents by Inventor William Frederick Carman

William Frederick Carman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hepatitis B vaccine
    Patent number: 6099840
    Abstract: A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified a determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as it is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 8, 2000
    Assignee: Imperial College of Science, Technology and Medicine
    Inventors: Howard Christopher Thomas, William Frederick Carman
  • Hepatitis B escape mutant specific binding molecules
    Patent number: 6030616
    Abstract: Molecules which are capable of specifically binding to a hepatitis B escape mutant antigenic determinant include monoclonal antibodies secreted by the cell line SMH HBs 145/G/R/I (ECACC 92122312). SMH HBs 145/R/I (ECACC 93052626). SMH HBs 145/G/II (ECACC 93033109) or SMH HBs 145/R/II (ECACC 93033110) and other specific binding molecules cross-competitive with them. Antibodies secreted by the cell lines SM HBs 145/G/R/I and SMH HBs 145/G/R/II bind variant (escape mutant) HBsAG and wild type HBsAG. Antibodies secreted by the cell lines SMH HBs 145/R/I and SMH HBs 145/R/II bind variant but not wild type.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: February 29, 2000
    Assignee: Imperial College of Science, Technology & Medicine
    Inventors: Jennifer Anne Waters, William Frederick Carman, Howard Christopher Thomas
  • Hepatitis B vaccine
    Patent number: 5989865
    Abstract: A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is dicslosed, in which the variant protein of fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: November 23, 1999
    Assignee: Imperial College of Science, Technology & Medicine
    Inventors: Howard Christopher Thomas, William Frederick Carman
  • Hepatitus B vaccine
    Patent number: 5854024
    Abstract: A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: December 29, 1998
    Assignee: Imperial College of Science Technology and Medicine
    Inventors: Howard Christopher Thomas, William Frederick Carman
  • Hepatitis B vaccine
    Patent number: 5851823
    Abstract: A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAG antibodies.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: December 22, 1998
    Assignee: Imperial College of Science Technology and Medicine
    Inventors: Howard Christopher Thomas, William Frederick Carman
  • Hepatitis B vaccine
    Patent number: 5639637
    Abstract: A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: June 17, 1997
    Assignee: Imperial College of Science, Technology & Medicine
    Inventors: Howard Christopher Thomas, William Frederick Carman