Patents by Inventor William Frederick Harrington

William Frederick Harrington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Genetically Modifying CIITA in a Cell
    Publication number: 20240139323
    Abstract: Compositions and methods for reducing MHC class II protein expression in a cell comprising genetically modifying CIITA for use e.g., in adoptive cell transfer therapies.
    Type: Application
    Filed: June 22, 2023
    Publication date: May 2, 2024
    Applicant: Intellia Therapeutics, Inc.
    Inventors: William Frederick Harrington, Surbhi Goel
  • Compositions and Methods for Reducing MHC Class II in a Cell
    Publication number: 20240016934
    Abstract: Compositions and methods for reducing MHC class II protein expression in a cell comprising genetically modifying CIITA for use e.g., in adoptive cell transfer therapies.
    Type: Application
    Filed: June 9, 2023
    Publication date: January 18, 2024
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Srijani Sridhar, Yong Zhang, William Frederick Harrington, Surbhi Goel
  • Polynucleotides, Compositions, and Methods for Genome Editing Involving Deamination
    Publication number: 20240002820
    Abstract: Polynucleotides, polypeptides, compositions, and methods for genome editing using deamination are provided. An mRNA containing an open reading frame (ORF) encoding a polypeptide is provided herein. The polypeptide includes a cytidine deaminase and an RNA-guided nickase, and does not include a uracil glycosylase inhibitor (UGI). A composition provided herein may include two different mRNAs. The first mRNA includes an ORF encoding a cytidine deaminase and an RNA-guided nickase, and the second mRNA includes an ORF encoding uracil glycosylase inhibitor (UGI).
    Type: Application
    Filed: June 9, 2023
    Publication date: January 4, 2024
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Christian Dombrowski, William Frederick Harrington, Ruan Oliveira