Patents by Inventor William Frietze

William Frietze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SALTS AND PROCESSES OF PREPARING A PI3K INHIBITOR
    Publication number: 20160257689
    Abstract: The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3K?), as well as a salt form and intermediates related thereto.
    Type: Application
    Filed: February 26, 2016
    Publication date: September 8, 2016
    Inventors: Lei Qiao, Lingkai Weng, ChongShen Eric Shi, David Meloni, Qiyan Lin, Michael Xia, Vaqar Sharief, William Frietze, Zhongjiang Jia, Yongchun Pan, Pingli Liu, Tai-Yuen Yue, Jiacheng Zhou
  • PROCESS FOR THE SYNTHESIS OF AN INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR
    Publication number: 20160221996
    Abstract: The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N?-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.
    Type: Application
    Filed: April 7, 2016
    Publication date: August 4, 2016
    Inventors: Ming Tao, William Frietze, David J. Meloni, Lingkai Weng, Jiacheng Zhou, Yongchun Pan
  • Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
    Patent number: 9321755
    Abstract: The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N?-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: April 26, 2016
    Assignees: Incyte Corporation, Incyte Holdings Corporation
    Inventors: Ming Tao, William Frietze, David J. Meloni, Lingkai Weng, Jiacheng Zhou, Yongchun Pan
  • PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO
    Publication number: 20150344497
    Abstract: This invention relates to processes for preparing a JAK1 inhibitor having Formula Ia: as well as new forms of the inhibitor.
    Type: Application
    Filed: April 29, 2015
    Publication date: December 3, 2015
    Applicant: INCYTE CORPORATION
    Inventors: Jiacheng Zhou, Pingli Liu, Shili Chen, Yongzhong Wu, Dengjin Wang, Zhongjiang Jia, Lei Qiao, William Frietze, Michael Xia, Yingrui Dai
  • Ethanamine compounds and methods of using the same
    Patent number: 9035065
    Abstract: The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: May 19, 2015
    Assignee: AstraZeneca AB
    Inventors: Michael Balestra, Peter Bernstein, Glen E. Ernst, William Frietze, John McCauley, David Nugiel, Lihong Shen
  • PROCESS FOR THE SYNTHESIS OF AN INDOLEAMINE 2,3-DIOXYGENASE INHIBITOR
    Publication number: 20150133674
    Abstract: The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N?-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Applicant: INCYTE CORPORATION
    Inventors: Ming Tao, William Frietze, David J. Meloni, Lingkai Weng, Jiacheng Zhou, Yongchun Pan
  • Ethanamine Compounds and Methods of Using the Same
    Publication number: 20120277272
    Abstract: (S)-2-methyl-1-phenyl-2-(pyridin-2-yl)propan-1-amine, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, uses of said compound or salt for therapy of depression and other conditions, and methods of treating depression and other conditions by administering said compound or salt.
    Type: Application
    Filed: March 27, 2012
    Publication date: November 1, 2012
    Applicant: ASTRAZENECA AB
    Inventors: Michael Balestra, Peter Bernstein, Glen E. Ernst, William Frietze, John P. McCauley, Lihong Shen, David Nugiel
  • Ethanamine Compounds and Methods of Using the Same
    Publication number: 20120115913
    Abstract: The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound.
    Type: Application
    Filed: August 29, 2011
    Publication date: May 10, 2012
    Inventors: Michael Balestra, Peter Bernstein, Glen E. Ernst, William Frietze, John P. McCauley, Lihong Shen, David Nugiel
  • 2-AZA-BICYCLO[2.2.1]HEPTANE COMPOUNDS AND USES THEREOF
    Publication number: 20120094995
    Abstract: This invention relates to 2-aza-bicyclo[2.2.1]heptane compounds (and salts thereof), the process for making such a compound and pharmaceutical compositions comprising such a compound. The invention also relates to the use of the compounds for modulating the glycine transporter 1 (GlyT1) and for the treatment of psychosis, cognitive disorders, bipolar disorders, depression disorders, anxiety disorders, post-traumatic stress disorders and pain.
    Type: Application
    Filed: January 27, 2010
    Publication date: April 19, 2012
    Applicant: ASTRAZENECA AB
    Inventors: Jeffrey Scott Albert, Donald Andisik, Cristobal Alhambra, Todd Andrew Brugel, Glen E Ernst, William Frietze, Lindsay Hinkley, Jeffrey Gilbert Varnes, Xia Wang, Hui Xiong
  • Ethanamine compounds and methods of using the same 545
    Patent number: 8013165
    Abstract: The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: September 6, 2011
    Assignee: AstraZeneca AB
    Inventors: Michael Balestra, Peter Bernstein, Glen E. Ernst, William Frietze, John P McCauley, Lihong Shen, David Nugiel
  • Ethanamine Compounds and Methods of Using the Same 545
    Publication number: 20100179199
    Abstract: The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound.
    Type: Application
    Filed: December 22, 2009
    Publication date: July 15, 2010
    Applicant: AstraZeneca AB
    Inventors: Michael Balestra, Peter Bernstein, Glen E. Ernst, William Frietze, John P. McCauley, Lihong Shen, David Nugiel
  • Thiophene-2-Carboxamide Derivatives as Alpha 7 Nicotinic Receptor Modulators
    Publication number: 20090012127
    Abstract: Compounds of Formula (I) wherein E, A and R1 are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: June 26, 2006
    Publication date: January 8, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Thomas R. Simpson, Michael Balestra, Dean G. Brown, Cathy L. Dantzman, Glen E. Ernst, William Frietze, Christopher R. Holmquist, James Kang, Frances M. McLaren, Reed W. Smith, JR., James M. Woods
  • Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors
    Publication number: 20080081833
    Abstract: Compounds of Formula I: wherein A1, A2, D and E are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.
    Type: Application
    Filed: December 16, 2005
    Publication date: April 3, 2008
    Applicant: AstraZeneca AB
    Inventors: Glen Ernst, William Frietze, Thomas Simpson
  • Nicotinic Acetylcholine Receptor Ligands
    Publication number: 20070249588
    Abstract: Acetylcholine receptor ligands of formula (I), wherein D, Ar1, E and Ar2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: December 20, 2004
    Publication date: October 25, 2007
    Applicant: AstraZeneca AB
    Inventors: Glen Ernst, William Frietze, Robert Jacobs, Eifion Phillips
  • Nicotinic AcetylcholineReceptor Ligands
    Publication number: 20070244097
    Abstract: Acetylcholine receptor ligands of formula I wherein D, E and G are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: December 20, 2004
    Publication date: October 18, 2007
    Applicant: AstraZeneca AB
    Inventors: Glen Ernst, William Frietze, Robert Jacobs, Eifion Phillips