Patents by Inventor William G. DEVINE

William G. DEVINE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL GSPT PROTEIN DEGRADER AND APPLICATION THEREOF
    Publication number: 20260109702
    Abstract: The present disclosure relates to novel compounds that act as modulators of cereblon (CRBN). The compounds promote CRBN-mediated ubiquitination and proteasomal degradation of oncogenic proteins such as GSPT1 and MYC, thereby suppressing abnormal cell growth. Pharmaceutical compositions containing the compounds and methods of using the compositions for the treatment of cancers, particularly solid tumors, are also provided.
    Type: Application
    Filed: October 17, 2025
    Publication date: April 23, 2026
    Inventors: Wongil LEE, Jang Sik CHOI, Ravi DASHNAMOORTHY, Vinay SAGAR, Travis CLARK, Miyong YONG, Anu GUPTA, Jaekyoo LEE, Jong Sung KOH, William G. DEVINE
  • SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND THEIR USES THEREOF
    Publication number: 20240374582
    Abstract: The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.
    Type: Application
    Filed: July 4, 2024
    Publication date: November 14, 2024
    Inventors: Wongil LEE, William G. DEVINE, R. Bruce DIEBOLD, So Young HWANG, Yunggeun CHOI, Yan LIU, Sang-Ae SEUNG, Miyong YONG, Sewon KIM, Jaekyoo LEE, Jong Sung KOH
  • Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof
    Patent number: 12064426
    Abstract: The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.
    Type: Grant
    Filed: January 5, 2022
    Date of Patent: August 20, 2024
    Assignee: GENOSCO Inc.
    Inventors: Wongil Lee, William G. Devine, R. Bruce Diebold, So Young Hwang, Yunggeun Choi, Yan Liu, Sang-Ae Seung, Miyong Yong, Sewon Kim, Jaekyoo Lee, Jong Sung Koh
  • SELECTIVE INHIBITORS OF ROCK1 AND ROCK2 PROTEIN KINASES AND USES THEREOF
    Publication number: 20230082993
    Abstract: The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.
    Type: Application
    Filed: January 5, 2022
    Publication date: March 16, 2023
    Inventors: Wongil LEE, William G. DEVINE, R. Bruce DIEBOLD, So Young HWANG, Yunggeun CHOI, Yan LIU, Sang-Ae SEUNG, Miyong YONG, Sewon KIM, Jaekyoo LEE, Jong Sung KOH