Abstract: An ice making machine includes a heat pipe that extends between a freezer compartment and a refrigerator compartment. The heat pipe has a first end in the freezer compartment and a second end in the refrigerator compartment. A heat exchanger is located in the freezer compartment and is in contact with the first end of the heat pipe. A heat block is located in the refrigerator compartment and is in contact with the second end of the heat pipe. A removable ice cube tray is mounted on the heat block with a surface in contact with the heat block such that when the removable ice cube tray is filled with water, ice forms from the surface of the removable ice cube tray in contact with the block.

Abstract: The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of cancer, particularly detection of prostate cancer.

Abstract: The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes having CpG island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (MBD) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. Additionally, compounds identified by the present invention useful for treatment and prevention of diseases, such as cancer and sickle cell anemia, are provided.

Abstract: The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of cancer, particularly detection of prostate cancer.

Abstract: A carbonator tank includes a liquid inlet, a gas inlet and a liquid outlet. A liquid level sensor includes a liquid level sensing portion extending along and within the interior of the carbonator and provides for determining a full and minimal liquid level therein. The level sensor includes an outer contact portion for connection to an electronic control and the contact portion is integral with the liquid inlet. Additionally, the level sensor includes a deflection plate extending from the liquid level sensing portion in a direction there from that is transverse to the direction of flow of liquid into the carbonator interior through the liquid inlet. The liquid then flows into the carbonator interior and contacts the deflection plate and is deflected thereby so that such liquid flow does not disrupt the operation of the level sensing portion of the level sensor.

Abstract: Provided are methods and compositions useful for the diagnosis, prognosis and treatment of hepatic cellular proliferative disorders. The methods include the modulation or analysis of hypemethylated glutathione-S-transferase nuleic acid sequence in hepatic samples and biological fluids.

Abstract: The present invention provides for enriching rare cells in a fluid comprising the rare cells and non-rare cells. Examples of rare cells enriched include prostate cancer cells.

Abstract: An inductive drive motor is shown wherein a magnetic rotor is positioned within an enclosed space defined by a housing surface. A stator is positioned around the surface in close contact therewith wherein the rotor is positioned substantially centrally thereof. The stator includes windings around the perimeter thereof wherein a phased flow of current therein provides for the creation of a magnetic field for rotatively driving the rotor. The rotor can be connected to various devices for mixing or scraping various liquid contents within the enclosed space. The stator windings are completely encapsulated in a corrosion resistant material, such as, a suitable plastic. Thus, the inductive drive motor has an extended life when used in corrosive environments.

Abstract: The present invention is a mechanical refrigeration system and method of operation thereof including a compressor, a condenser, an expansion valve an evaporator, a hot gas bypass line and a hot gas valve. A control regulates the operation of the compressor and the hot gas valve and, upon determining that the compressor is to be shut off, first opens the hot gas valve for a predetermined time period to reduce any pressure differential between the high and low pressure sides of the compressor. This pressure reduction providing for reducing or eliminating any destructive compressor movement that would otherwise occur at shut down as the momentum of the moving parts of the compressor operate against a pressure differential. A similar method can be used to avoid such unwanted movement at start-up of the compressor.

Abstract: A method for enriching cancer cells such as prostate cancer cells in a bodily fluid sample is disclosed comprising (a) obtaining the sample comprising cancer cells and non-rare cells; (b) subjecting the sample to multiple density gradient separation comprising a first density gradient and a second density gradient, wherein the second density gradient is greater than the first density gradient, and producing a first fluid comprising an increased concentration of cancer cells of a first density, and a second fluid comprising an increased concentration of cancer cells of a second density, wherein the second density is greater than the first density; wherein subjecting the sample to multiple density gradient separation includes producing a plasma layer, a first interface layer, a first gradient layer, a second interface layer, a second gradient layer, and a cell pellet; wherein producing the first fluid includes combining the first interface layer and the first gradient layer and forming a first suspension; and w

Abstract: A vapor compression refrigeration system having a condenser, a regulating device, and a capillary tube. The regulating device has a housing defining an inner chamber for receiving refrigerant from the condenser. A float is disposed within the chamber and includes a resilient surface. An outlet line connected to the capillary tube extends through a bottom wall of the housing and into the chamber. The float is movable in response to changes in level of refrigerant in the chamber. The float moves downward to close the outlet line when refrigerant in the chamber drops below a minimum level, and moves upward to open the outlet line when refrigerant in the chamber rises above the minimum level. A filter assembly for removing contaminants from the refrigerant is disposed within the chamber above the float.

Abstract: A method for detecting and a method for treating a cell proliferative disorder associated with glutathione-S-transferase (GSTP1) expression is provided. The method includes direct detection of a hypermethylated GSTP1 promoter, or indirect detection of decreased GSTP1 mRNA or GSTP1 protein in a suspect tissue sample.

Abstract: A household type refrigerator has a refrigeration system including a subcooling flow control valve placed between the outlet of the condenser and the inlet to the capillary tube. The subcooling flow control valve utilizes a sealed capsule of refrigerant which operates to open and close a valve to modulate the flow from the condenser to the capillary tube to insure only that a subcooled liquid enters the capillary. The valve is mounted vertically next to the compressor and has the inlet line to the valve secured in heat conducting contact to the return line to the compressor for faster opening and closing response while the discharge side of the valve has a chamber filled with a plug to minimize the volume of refrigerant remaining between the closed valve and the entrance to the capillary when the compressor is on the off cycle.