Patents by Inventor William G. Salmond

William G. Salmond has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4267117
    Abstract: A process for preparing 1.alpha.-hydroxylated calciferols is described. Intermediates used in the process are also provided.
    Type: Grant
    Filed: June 14, 1979
    Date of Patent: May 12, 1981
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 4206131
    Abstract: A process for preparing 1.alpha.-hydroxylated calciferols is described. Intermediates used in the process are also provided.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: June 3, 1980
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 4116985
    Abstract: A new method for synthesizing cholesta-5,7-diene-3.beta.,-25-diol and cholesta-5,7-diene-1.alpha.,3.beta.,25-triol has been discovered. ##STR1## wherein R is hydrogen or hydroxy. Various intermediates and reaction steps are claimed.
    Type: Grant
    Filed: July 26, 1976
    Date of Patent: September 26, 1978
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 4107439
    Abstract: 2-Aryl-C.sub.3 to C.sub.6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The ester intermediate product is then converted to the corresponding 2-aryl-C.sub.3 to C.sub.6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as an anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.
    Type: Grant
    Filed: June 16, 1976
    Date of Patent: August 15, 1978
    Assignee: The Upjohn Company
    Inventors: Jerry A. Walker, David R. White, William G. Salmond
  • Patent number: 4094890
    Abstract: A method for preparing 9.beta.,10.alpha.-chloesta-5,7-diene-3.beta.,25 diol and 25-hydroxyprevitamin D.sub.3 by irradiation.
    Type: Grant
    Filed: August 26, 1976
    Date of Patent: June 13, 1978
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 4066665
    Abstract: Compounds of the formula ##STR1## wherein R and R.sup.o are lower alkyl, R' is optionally substituted phenyl or 2-thienyl and n is 0 to 2, and their salt forms, are prepared by reacting a compound of the formula: ##STR2## with an aromatic nitrile and strong base, and quenching with water when the free base form is desired, said first mentioned compounds being intermediates for quinazolinones.
    Type: Grant
    Filed: June 19, 1974
    Date of Patent: January 3, 1978
    Assignee: Sandoz, Inc.
    Inventor: William G. Salmond
  • Patent number: 4058538
    Abstract: 3.alpha.,5.alpha.-cyclo-6.beta.-alkoxy-.DELTA..sup.22 -25-hydroxy, oxy and acyloxy bisnorcholestane and analogues.
    Type: Grant
    Filed: July 26, 1976
    Date of Patent: November 15, 1977
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 4042596
    Abstract: 2-Alkyl-5-phenethyl-4-oxazolecarboxylic acids, esters and carbonyl halides are disclosed, which are useful as intermediates in the preparation of known benzocycloheptaoxazoles.
    Type: Grant
    Filed: September 1, 1976
    Date of Patent: August 16, 1977
    Assignee: Sandoz, Inc.
    Inventor: William G. Salmond
  • Patent number: 4006172
    Abstract: Disclosed is an improved process for the oxidation of certain .DELTA..sup.5 -steroids to the corresponding 7-keto-.DELTA..sup.5 -steroids by use of a chromium trioxide-pyrazole oxidant (oxidizing agent).
    Type: Grant
    Filed: April 26, 1976
    Date of Patent: February 1, 1977
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 4001096
    Abstract: A method for preparing 9.beta., 10.alpha.-cholesta-5,7-diene-3.beta.,25 diol and 25-hydroxyprevitamin D.sub.3 by irradiation.
    Type: Grant
    Filed: February 21, 1975
    Date of Patent: January 4, 1977
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 3996227
    Abstract: Compounds of the formula I: ##SPC1##whereinR.degree. is lower alkyl,n is 0, 1 or 2,R is lower alkyl,R' is a radical of the formula ##SPC2##In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC3##In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms,Are prepared by cyclizing a compound of formula II ##SPC4##in which R, R', R.degree. and n are as defined above, with phosgene, or,Where R is not a tertiary alkyl group in which the tertiary carbon atom is directly attached to the ring nitrogen atom, with a C.sub.1 -C.sub.2 alkyl chlorocarbonate or 1,1'carbonyldiimidazole. The compounds of formula I possess pharmaceutical activity in animals.
    Type: Grant
    Filed: June 19, 1974
    Date of Patent: December 7, 1976
    Assignee: Sandoz, Inc.
    Inventor: William G. Salmond
  • Patent number: 3994915
    Abstract: Benzocycloheptaoxazolones are prepared by a multi-step process starting with a lower alkyl ester of a 3-oxo-5-phenylvaleric acid. The compounds are useful as anti-inflammatories and as intermediates in the preparation of pharmaceutically useful compounds.
    Type: Grant
    Filed: January 6, 1975
    Date of Patent: November 30, 1976
    Assignee: Sandoz, Inc.
    Inventor: William G. Salmond
  • Patent number: 3994894
    Abstract: Anti-inflammatory and analgesic agents of the formula I: ##SPC1##whereinR.degree. is lower alkyl,N IS 0, 1 OR 2,R is lower alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or phenyl,R' is a radical of the formula ##SPC2##In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC3##In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms,Are prepared by cyclizing a compound of formula II: ##SPC4##in which R, R', R" and n are as defined above, with, for example, phosgene.
    Type: Grant
    Filed: January 8, 1975
    Date of Patent: November 30, 1976
    Assignee: Sandoz, Inc.
    Inventor: William G. Salmond
  • Patent number: 3994934
    Abstract: A new method of preparing 3.alpha.,5.alpha.-cyclo-6.beta.-alkoxy-.DELTA..sup.22 -25-oxy or acyloxy bisnorcholestane and analogues which involves reacting a bisnorcholanaldehyde with an ylide. Novel cholestanes and i-ethers are also claimed.
    Type: Grant
    Filed: January 27, 1975
    Date of Patent: November 30, 1976
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 3976636
    Abstract: A method for preparing 25-hydroxycholesterol and novel intermediates.
    Type: Grant
    Filed: October 10, 1974
    Date of Patent: August 24, 1976
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 3970676
    Abstract: A method for preparing the 5,7- steroid diene illustrated below, and intermediates thereof, has been discovered.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: July 20, 1976
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 3959320
    Abstract: A method for preparing 25-hydroxycholesterol and novel intermediates.
    Type: Grant
    Filed: September 23, 1974
    Date of Patent: May 25, 1976
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 3945960
    Abstract: Anti-inflammatory and analgesic agents of the formula I: ##SPC1##whereinn is 2 to 7,R.degree. is lower alkyl,m is 0, 1 or 2,R is lower alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or phenyl,R' is a radical of the formula ##SPC2##In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC3##In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms, are prepared by cyclizing a compound of the formula II ##SPC4##in which R, R', R.degree., m and n are as defined above, with, for example, phosgene.
    Type: Grant
    Filed: July 26, 1973
    Date of Patent: March 23, 1976
    Assignee: Sandoz, Inc.
    Inventor: William G. Salmond
  • Patent number: 3941787
    Abstract: Anti-inflammatory agents of the formula I: ##SPC1##whereinR is lower alkyl, cycloalkyl or cycloalkylalkyl,R' is a radical of the formula ##SPC2##in which Y and Y' are hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl, or a radical of the formula ##SPC3##in which Y" is hydrogen, halo or alkyl,Are prepared by cyclizing a compound of formula II ##SPC4##in which R and R' are as defined above, with phosgene.
    Type: Grant
    Filed: July 22, 1974
    Date of Patent: March 2, 1976
    Assignee: Sandoz, Inc.
    Inventor: William G. Salmond