Abstract: A bottom loaded filter assembly for filtering radioactive liquids through a replaceable cartridge filter. The filter assembly includes a lead-filled jacket enveloping a housing having a chamber therein for the filter cartridge. A track arrangement carries a hatch for sealing the chamber. A spacer plug supports the cartridge within guide means associated with the inlet conduit in the chamber. The plug and cartridge drop out of the chamber when the hatch is unbolted and move laterally of the chamber. During cartridge replacement, a new plug and cartridge are supported in the guide means by a spacer bar inserted across the track means under the chamber. The hatch is then slid under the chamber and bolted to the vessel, engaging an O-ring to seal the chamber.