Patents by Inventor William Garner

William Garner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Choline Esters
    Publication number: 20220151988
    Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.
    Type: Application
    Filed: February 4, 2022
    Publication date: May 19, 2022
    Inventors: William GARNER, Margaret GARNER, George MINNO, David GOODEN
  • Choline Esters
    Publication number: 20200352903
    Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.
    Type: Application
    Filed: February 14, 2020
    Publication date: November 12, 2020
    Inventors: William GARNER, Margaret GARNER, George MINNO, David GOODEN
  • Choline Esters
    Publication number: 20180228767
    Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.
    Type: Application
    Filed: December 11, 2017
    Publication date: August 16, 2018
    Inventors: William GARNER, Margaret GARNER, George MINNO, David GOODEN
  • Method of treating presbyopia using dithiol compounds and their derivatives
    Patent number: 10039743
    Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: August 7, 2018
    Assignee: NOVARTIS AG
    Inventors: William Garner, Margaret Garner, George Minno, David Gooden
  • DITHIOL COMPOUNDS, DERIVATIVES, AND USES THEREFOR
    Publication number: 20170231951
    Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.
    Type: Application
    Filed: December 20, 2016
    Publication date: August 17, 2017
    Inventors: William GARNER, Margaret GARNER, George MINNO, David GOODEN
  • Dithiol compounds, derivatives, and uses therefor
    Patent number: 9567314
    Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: February 14, 2017
    Assignee: Encore Health LLC
    Inventors: William Garner, Margaret Garner, George Minno, David Gooden
  • Low dose lipoic acid pharmaceutical compositions and methods
    Patent number: 9517225
    Abstract: Compositions containing low doses of lipoic acid-based active agents and methods for using the same are provided. In particular, compositions containing low dose lipoic acid, lipoic acid derivatives, said lipoic acid seleno-derivatives and are provided to prevent and/or treat ocular diseases.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: December 13, 2016
    Assignee: Encore Health, LLC
    Inventors: William Garner, Margaret Garner
  • Choline Esters
    Publication number: 20160287557
    Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.
    Type: Application
    Filed: April 5, 2016
    Publication date: October 6, 2016
    Inventors: William GARNER, Margaret Garner, George Minno, David Gooden
  • Dithiol Compounds, Derivatives, and Uses Therefor
    Publication number: 20160264545
    Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.
    Type: Application
    Filed: March 11, 2016
    Publication date: September 15, 2016
    Inventors: William GARNER, Margaret Garner, George Minno, David Gooden
  • COMPOSITIONS TO IMPROVE THE THERAPEUTIC BENEFIT OF BISANTRENE AND ANALOGS AND DERIVATIVES THEREOF
    Publication number: 20160220537
    Abstract: The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to bisantrene or derivatives, analogs, or prodrugs thereof.
    Type: Application
    Filed: July 25, 2014
    Publication date: August 4, 2016
    Inventors: William GARNER, Amie FRANKLIN, John ROTHMAN
  • USE OF DIANHYDROGALACTITOL AND ANALOGS AND DERIVATIVES THEREOF TO TREAT RECURRENT MALIGNANT GLIOMA OR PROGRESSIVE SECONDARY BRAIN TUMOR
    Publication number: 20160158186
    Abstract: Methods and compositions suitable for the treatment of malignancies such as recurrent glioma and progressive secondary brain tumor are disclosed. These methods employ a hexitol derivative such as dianhydrogalactitol, a derivative or analog of dianhydrogalactitol, diacetyldianhydrogalactitol, or a derivative or analog of diacetyldianhydrogalactitol. The compositions can include such hexitol derivatives.
    Type: Application
    Filed: April 9, 2015
    Publication date: June 9, 2016
    Inventors: Dennis M. BROWN, Kent C. SHIH, Anne STEINO, Richard SCHWARTZ, Sareth KANEKAL, Howard A. BURRIS, III, Jeffrey BACHA, William GARNER
  • Choline esters
    Patent number: 9326970
    Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: May 3, 2016
    Assignee: Encore Health LLC
    Inventors: William Garner, Margaret Garner, George Minno, David Gooden
  • Methods of treating ocular diseases using derivatives of lipoic acid
    Patent number: 9284305
    Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating an ocular disease, especially presbyopia and cataract. Also provided are methods of treating an ocular disease, the methods comprising administering to a subject an active agent and an adjunctive agent.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: March 15, 2016
    Assignee: Encore Health, LLC
    Inventors: William Garner, Margaret Garner, George Minno, David Gooden
  • Low Dose Lipoic Acid Pharmaceutical Compositions and Methods
    Publication number: 20150297561
    Abstract: Compositions containing low doses of lipoic acid-based active agents and methods for using the same are provided. In particular, compositions containing low dose lipoic acid, lipoic acid derivatives, said lipoic acid seleno-derivatives and are provided to prevent and/or treat ocular diseases.
    Type: Application
    Filed: April 27, 2015
    Publication date: October 22, 2015
    Inventors: William GARNER, Margaret GARNER
  • Dithiol compounds and treatment of presbyopia using said compounds
    Patent number: 9161931
    Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract. Also disclosed are novel mercaptan compounds, particularly those including a photolabile protecting group, as well as methods of using the compounds for the prevention and treatment of ocular damage and disease.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: October 20, 2015
    Assignee: Encore Health, LLC
    Inventors: William Garner, Margaret Garner, Ronald D. Blum
  • Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid
    Publication number: 20150246903
    Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.
    Type: Application
    Filed: June 12, 2014
    Publication date: September 3, 2015
    Inventors: William GARNER, Margaret GARNER, George MINNO, David GOODEN
  • Low dose lipoic and pharmaceutical compositions and methods
    Patent number: 9044439
    Abstract: Compositions containing low doses of lipoic acid-based active agents and methods for using the same are provided. In particular, compositions containing low dose lipoic acid, lipoic acid derivatives, and lipoic acid seleno-derivatives and are provided to prevent and/or treat ocular diseases.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: June 2, 2015
    Assignee: Encore Health, LLC
    Inventors: William Garner, Margaret Garner
  • Choline Esters
    Publication number: 20150111959
    Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.
    Type: Application
    Filed: October 28, 2014
    Publication date: April 23, 2015
    Inventors: William GARNER, Margaret Garner, George Minno, David Gooden
  • Methods of Treating Ocular Diseases Using Derivatives of Lipoic Acid
    Publication number: 20140357691
    Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.
    Type: Application
    Filed: June 12, 2014
    Publication date: December 4, 2014
    Inventors: William GARNER, Margaret GARNER, George MINNO, David GOODEN
  • Dithiol Compounds, Derivatives, and Uses Therefor
    Publication number: 20140243385
    Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract. Also disclosed are novel mercaptan compounds, particularly those including a photolabile protecting group, as well as methods of using the compounds for the prevention and treatment of ocular damage and disease.
    Type: Application
    Filed: January 31, 2014
    Publication date: August 28, 2014
    Applicant: Encore Health, LLC
    Inventors: William GARNER, Margaret Garner, Ronald D. Blum